It's effect lasts for 5-10 minutes, normal IV injections are unlikely to work no matter what to summarise everything i'm about to yap about
Michael jackson accidentally died of a propofol overdose but he was connected to a IV infusion device, most people here don't know how to use needles and set up cannulas and IV infusion devices, creating a setup for this method is very difficult and convoluted and technical, people rarely study pharmacology and pharmacokinetics, that's why these methods are rarely brought up, and if you could get propofol OTC like that and you have the skills to set it up and configure a IV infusion device to pump stuff at a good pace to sustain CNS depression until apnea and respitatory arrest occurs you'd probably be able to find other GABA-A agonists with better duration of action
It just won't work with a syringe or a needle, it can't contain 1000mg of propofol in one syringe or needle and even if it does you'll never inject it in time before falling unconscious, the concentations are usually 10mg propofol per 1 milileter (1000mg propofol = 100 ml)
It's not impossible to circumvent this if you know how to synthesize propofol and emulsify and sterilize it (synthesized propofol is highly lipid, needs to be emulsified otherwise you're trying to inject a rock into your vein, it won't work otherwise), if you can do this then you could get a molecule with your own rules, like 10ml/1 gram, theorically, you can inject it all before losing consciousness if you do it perfectly or practise beforehand, but so long as propofol's duration of action is 5-10 minutes, there are still a few hurdles you have to pass now that you've pulled off the impossible and injected 1 gram of propofol intravenously before losing consciousness
If it goes perfectly in this scenario (a simple and quick needle injection) and you immediately go into deep CNS depression to the extent apnea happens almost immediately, and the molecule holds up for 10 minutes, then keep in mind permanent brain damage starts only after 4 minutes without oxygen and death can occur as soon as 4 to 6 minutes later if apnea is consistent, you can end up vegetative if it fails, and brain damage will always happen in this scenario should propofol's duration of action betray you
This method is unpractical for normal people, high skill in execution and very complex in proper set-ups that can work, i don't think anyone other than healthcare professionals who know how to hit a good, set up a cannula and a IV infusion device properly, could really pull it off in real life, and even if they could they'd be smart enough to realise how difficult it is to pull off and know the risks of trusting your fate to a short duration of action drug if your setup was flawed
I think you didn't read the thread completely. What this thread mentions isn't 1% propofol for medical use. It's Anestofol. It's propofol for euthanasia, of Russian origin. It comes in vials as 10cc Anestofol = 5% Propofol + 5% Lidocaine. So, 10cc Anestofol contains 500mg propofol + 500mg lidocaine. The onset of action of propofol is 15 seconds from the moment you start pushing the plunger. With a 22g cannula, you can inject 25-30ccs into a large vein in the arm in 15 seconds. That means 1500mg propofol + 1500mg lidocaine for 30cc Anestofol. Actually, even 20cc is enough.
I'm leaving below the graph generated by the "stan pump" pharmacokinetic simulation model to see what happens if a 30-year-old, 70kg, healthy, non-addicted man takes 1000mg propofol and standart induction dose. In this scenario, respiratory arrest wouldn't be the cause of death. Propofol's sympatholytic effect leads to vasodilation ---> profound hypotension ---> cardiovascular collapse. Of course, sympatholytic effects aren't the only factor in the equation. Propofol causes myocardial depression at high doses, reducing cardiac output. While this alone is enough, if we also factor in the negative inotropic effects of 1000mg lidocaine, the only way someone could survive in this scenario is if they are coming from the planet Krypton and the letter "S." Due to a misunderstanding at the hospital, the patient was given 300mg of propofol instead of 150mg. Despite immediate intubation and inotriopic support through two IV cannulas, he could not be resuscitated. This is because there is no reversal agent for propofol. Even the standard induction dose is always injected slowly to maintain hemodynamic stability.The other factor in the equation, of course, is airway collapse.
"If it goes perfectly in this scenario (a simple and quick needle injection) and you immediately go into deep CNS depression to the extent apnea happens almost immediately, and the molecule holds up for 10 minutes"
This is completely about dose. For a 70-kg person, the average dose is 2.5 mg/kg (without premedication). The target plasma concentration is 6 mcg/ml. At this concentration, awakening is expected within 10 minutes. If the dose reaches an absurd peak of 60 mcg/ml, as described above, awakening will take much longer, but of course, the person will not wake up.
Still there is a problem. Propofol injections are painful. While phenol injections are painful, the real source of pain is the oil. The Germans developed Propofol Lipuro to reduce propofol pain. While Anestofol contains lidocaine, this isn't a solution because lidocaine requires time to work. The injection is still painful. A solution could be to inject lidocaine before Anestofol, but even this doesn't completely solve the problem. This is the main problem with Anestofol. There's a better way to numb a vein, but it's too difficult for someone who isn't a healthcare professional.
"This method is unpractical for normal people, high skill in execution and very complex in proper set-ups that can work, i don't think anyone other than healthcare professionals who know how to hit a good, set up a cannula and a IV infusion device properly, could really pull it off in real life, and even if they could they'd be smart enough to realise how difficult it is to pull off and know the risks of trusting your fate to a short duration of action drug if your setup was flawed"
I agree with this. Catheterization, drip infusion setup, and management of an infusion pump are unrealistic for a non-healthcare professional. Catheterization is enough for the 20cc anestofol bolus method. For the average person, learning catheterization takes 3-4 months. Maybe more.
Его продавали на торговой площадке Ozon. Сейчас, я вижу, его там больше нет. Среди сотен отзывов было два-три, где говорилось, что он не работает. Не знаю, может, его неправильно использовали.
I'll look for 2% propofol
In my opinion, thiopental is currently the best option for IV use from "IM" (source). The injection is less painful than propofol, and since it comes in powder form, dosing is easy.
