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Valhala

Valhala

Specialist
Jul 30, 2024
381
Let's assume this "works" and is probably even faster and more comfortable than N - I don't doubt it, however; Propofol is hardly easier to obtain than N (perhaps for a nuance, but it is still quite demanding) and most importantly, this procedure is technically too complicated for most people - more complicated than the inert gas method. I doubt that someone who is a layman in the field would medical profession, decided on this method even if he managed to acquire all of the above.
 
summersolstice101

summersolstice101

Member
Jan 12, 2025
28
1000mg without an IV line .. I doubt it.
Yea it only works with an IV line.

Let's assume this "works" and is probably even faster and more comfortable than N - I don't doubt it, however; Propofol is hardly easier to obtain than N (perhaps for a nuance, but it is still quite demanding) and most importantly, this procedure is technically too complicated for most people - more complicated than the inert gas method. I doubt that someone who is a layman in the field would medical profession, decided on this method even if he managed to acquire all of the above.
Agreed that propofol can be extremely difficult to obtain, especially in tough places like Australia, it is a highly restricted medication.
However, OP does mention that there is a source with Russian pharmacies - I haven't personally checked if they can deliver through stringent Aus customs , but I think this is lead worth exploring for those that perform the procedure.

Also I see where you're coming from that this may not be the best approach for the layman.
I think for those people confident with medical literacy, and manual dexterity, this could be a useful alternative.
 
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Valhala

Valhala

Specialist
Jul 30, 2024
381
Yea it only works with an IV line.


Agreed that propofol can be extremely difficult to obtain, especially in tough places like Australia, it is a highly restricted medication.
However, OP does mention that there is a source with Russian pharmacies - I haven't personally checked if they can deliver through stringent customs, but I think this is lead worth exploring for those that perform the procedure.

Also I see where you're coming from that this may not be the best approach for the layman.
I think for those people confident with medical literacy, and manual dexterity, this could be a useful alternative.
I agree with you, I wrote something similar. If there is availability of Propofol at Russian clearnet pharmacies, that is certainly good news.
 
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Y

youpi

Member
Jul 4, 2024
47
You guys need to stop worrying about customs with the exception of a few country like Australia and some others, most things will pass.
 
Amarajoy

Amarajoy

Experienced
Sep 12, 2024
276
Fantastic

Really appreciate your post, this is fantastic work.
The fact that this is the method of choice by anesthesiologists speaks volumes to it's efficacy.

Many people have have commented concerns about the technicalities of the setting up an IV line. I understand that it may be extremely difficult for some to perform, and IV route can be restrictive in these ways. For those that are keen to learn and committed to this method, there are many sources online (even on youtube) which explain it step-by-step. If you are unable to find any videos or don't understand parts of it, feel free to message me and I can explain or provide some materials that can guide you.
Trying to get over the fear of sticking myself for the IV is my major hurdle.
 
summersolstice101

summersolstice101

Member
Jan 12, 2025
28
Trying to get over the fear of sticking myself for the IV is my major hurdle.
If the problem is the pain associated with getting jabbed, then it's not commonly used in adults, but you can try to numb the area - try topical anaestehtic creams, or try injecting some local anesthetic through a smaller needle over your site (but downside is it the fluid can make it more difficult to see the vein).
If it's a needlephobia, this is a bit more difficult to overcome, but it's all about exposure therapy, which is easier said than done. Start with looking at photos, then videos, then handling the equipment in person, trying on dummies, all that before trying on yourself.
 
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Amarajoy

Amarajoy

Experienced
Sep 12, 2024
276
If the problem is the pain associated with getting jabbed, then it's not commonly used in adults, but you can try to numb the area - try topical anaestehtic creams, or try injecting some local anesthetic through a smaller needle over your site (but downside is it the fluid can make it more difficult to see the vein).
If it's a needlephobia, this is a bit more difficult to overcome, but it's all about exposure therapy, which is easier said than done. Start with looking at photos, then videos, then handling the equipment in person, trying on dummies, all that before trying on yourself.
Thank you. Yes, it's the needle phobia for me. I can't watch when someone else does it so attempting it in myself seems pretty impossible at this point.
 
G

G50

Member
Jun 28, 2023
74
Absolutely. In my country, lidocaine injection before propofol is standard procedure.
And if I want to make the propofol method fail proof, it will not be KCL. I put an airtight bag over my head that prevent me from breathing. In this way, even 200-300mg of propofol would be enough. Of course, this also depends on factors such as age, drug addiction, weight. More propofol may be needed. For the average person with naive GABA receptors, the anesthesia induction dose is enough.

I am thinking about combining a propofol injection with a debreather apparatus I made. This apparatus cost me less than about $60 to make.

The propofol would just be to create unconsciousness while the debreather deprives you of oxygen

My debreather worked fine in terms of removing the carbon dioxide from the expelled breath, but I found even though the CO2 was removed from the air I was breathing, as oxygen levels went down in the debreather, and my blood oxygen saturation reached 70%, I had a strong compulsion to breathe fresh air.

I thought that once you removed the CO2, you would not have any compulsion to breathe as the oxygen goes down, but I found this is not the case.

Someone on my thread pointed out (in this post) that the body senses high blood CO2 which creates an urge to breathe (hypercapnic drive), but also the body senses low blood oxygen (hypoxic drive), and this also causes an urge to breathe.

So I realised that it would not be possible to use my debreather without taking some drug to make you unconscious, or some drug which is a respiratory depressant, so suppresses the hypoxic drive. Propofol is a respiratory depressant, so might even work in combination with my debreather apparatus even if you are not fully unconscious. If self-injecting propofol to the point you lose consciousness, this I hope would give you enough time in the unconscious state for the debreather to do its job.
 
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E

Endofpain

Member
Dec 21, 2024
92
Does anybody know where to get propofol? A dm would be greatly appreciated. I have found a russian online pharmacy that is legit. The problem is that they dont ship to my country...
 
Sunset Limited

Sunset Limited

I believe in Sunset Limited
Jul 29, 2019
1,338
I am thinking about combining a propofol injection with a debreather apparatus I made. This apparatus cost me less than about $60 to make.

The propofol would just be to create unconsciousness while the debreather deprives you of oxygen

My debreather worked fine in terms of removing the carbon dioxide from the expelled breath, but I found even though the CO2 was removed from the air I was breathing, as oxygen levels went down in the debreather, and my blood oxygen saturation reached 70%, I had a strong compulsion to breathe fresh air.

I thought that once you removed the CO2, you would not have any compulsion to breathe as the oxygen goes down, but I found this is not the case.

Someone on my thread pointed out (in this post) that the body senses high blood CO2 which creates an urge to breathe (hypercapnic drive), but also the body senses low blood oxygen (hypoxic drive), and this also causes an urge to breathe.

So I realised that it would not be possible to use my debreather without taking some drug to make you unconscious, or some drug which is a respiratory depressant, so suppresses the hypoxic drive. Propofol is a respiratory depressant, so might even work in combination with my debreather apparatus even if you are not fully unconscious. If self-injecting propofol to the point you lose consciousness, this I hope would give you enough time in the unconscious state for the debreather to do its job.
Propofol does not inhibit respiration in subanesthetic doses. You can inject yourself with enough propofol before you become unconscious. If you have IV experience. The anesthesia induction dose of propofol is 2.5 mg/kg without premedication.
 
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Csmith8827

Csmith8827

Don't you listen to your heart? (Listen to it...)
Oct 26, 2019
934
Can you test propofol to make sure its legit? Like its the real thing? And where do i buy such a test? And when i hook up the iv how much do i need? Can someone please explain the iv injection? And what happens if it doesnt work? Are there any side effects to a failed attempt?
 
Eudaimonic

Eudaimonic

I want to fade away.
Aug 11, 2023
736
I am thinking about combining a propofol injection with a debreather apparatus I made. This apparatus cost me less than about $60 to make.

The propofol would just be to create unconsciousness while the debreather deprives you of oxygen

My debreather worked fine in terms of removing the carbon dioxide from the expelled breath, but I found even though the CO2 was removed from the air I was breathing, as oxygen levels went down in the debreather, and my blood oxygen saturation reached 70%, I had a strong compulsion to breathe fresh air.

I thought that once you removed the CO2, you would not have any compulsion to breathe as the oxygen goes down, but I found this is not the case.

Someone on my thread pointed out (in this post) that the body senses high blood CO2 which creates an urge to breathe (hypercapnic drive), but also the body senses low blood oxygen (hypoxic drive), and this also causes an urge to breathe.

So I realised that it would not be possible to use my debreather without taking some drug to make you unconscious, or some drug which is a respiratory depressant, so suppresses the hypoxic drive. Propofol is a respiratory depressant, so might even work in combination with my debreather apparatus even if you are not fully unconscious. If self-injecting propofol to the point you lose consciousness, this I hope would give you enough time in the unconscious state for the debreather to do its job.
Maybe I'm misunderstanding, but why couldn't one just inhale the gas and breath-hold until they passed out from hypoxia?
 

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