Help Propranolol Overdose?

[Allpainnogain]

Try using verapamil if you can't get digoxin. Where I live it's way easier to get. Not sure about where you live. Digoxin lowers the heart rate but so does verapamil. It's a calcium channel blocker. A calcium channel blocker and a beta blocker like Propranolol are a dangerous combination in lowering blood pressure quick

Calcium Channel Blocker Overdose

At 2145 hours, 911 was contacted by an agitated male advising that his girlfriend was unconscious after having overdosed on some pills. On arrival, EMS found a 29-year-old female awake and alert. The patient admitted having taken 90 tablets of 180 mg tablets of verapamil Slow Release (SR). She...

www.jems.com

omg this story sounds horrific though - why does it have to be so hard to ctb!

Thinking to take 3g of Propranolol with 500mg of Diazepam. Can't seem to get hold of Digoxin and 10g of Morphine is bloody expensive (DDMP). Can anyone think of suitable substitutes for the Digoxin and Morphine? Mainly the Morphine, I think with a bit more digging I might be able to get ahold of the 25mg Digoxin needed.

What is DDMP?

Went through the site ages back and the number of deaths makes it seem like a viable option but I still don't think Propranolol alone will be enough. Have you had any luck getting a hold of Digoxin?

Where can you get digoxin or verapamil?

 

[CTB-London]

Thinking to take 3g of Propranolol with 500mg of Diazepam. Can't seem to get hold of Digoxin and 10g of Morphine is bloody expensive (DDMP). Can anyone think of suitable substitutes for the Digoxin and Morphine? Mainly the Morphine, I think with a bit more digging I might be able to get ahold of the 25mg Digoxin needed.

I've read that the fatal dose of Propranolol is is 3g plus. Adding in extra sedatives adds to the chance of it working. Benzos are a good idea because each medication slows down the metabolism of the other. I once (accidentally) knocked myself out for a day with Propranolol and a short acting benzo.

 

[Smith94]

Yeah I don't know what I was thinking when I wrote that, 3g would be leaving a lot to fate. I don't know what to do anymore, an OD is probably the easiest to carry out in terms of beating SI but one of the worst in the way of reliability. Still haven't managed to get any Digoxin or Verpamil.

Have you got any exit plans?

 

[CTB-London]

Yeah I don't know what I was thinking when I wrote that, 3g would be leaving a lot to fate. I don't know what to do anymore, an OD is probably the easiest to carry out in terms of beating SI but one of the worst in the way of reliability. Still haven't managed to get any Digoxin or Verpamil.

Have you got any exit plans?

I found that figure by researching online also. Propranolol is in my plans because it's easy to get hold of.

 

[FrankieMay]

I'm 5'5 and around 105lbs, 70x40mg pills was enough for me to flatline in December. I was unconscious by the time I was found seizing, cardiac arrest is what caused me to flatline. To save me I was put into a medically induced coma, my family were warned of brain damage and I was still expected to die until I woke up so I'd imagine brain damage is likely if you survive and I got pretty lucky. I didn't use antiemetics, mix them with any other drug or crush them, I just swallowed them all with a glass of water first thing in the morning on an empty stomach. I don't remember being in pain before I lost consciousness either so painless as far as I'm aware.

Just adding that it was actually an effort for the nurses to pull me out of this attempt, took 2 ambulances, 40 mins of chest compressions, intubation, coma, etc. I think this is a pretty reliable way to go. I was told by paramedics when I went back a month after for heart related issues (probably due to this attempt) that they all expected me to die & the first one to treat me cried when she saw me alive. If I am to CTB I'll use propranolol again.

I had the exact same experience, ended up on ecmo life support
Took 4.3g, half a bottle of wine
I'm 5'9, 65kg

 

[AveryConure]

thinking of calling my psych tomorrow to get these. i may have to stockpile these every month but i'm just desperate to leave now it's either od on prescription pills or train and one is a more peaceful option than the other

 

[Mogley26]

Ah lovely propranolol.... it's a good one. Be very careful to not get caught. The grams are good. Add opiates or something else to help depress breathing and blood pressure. Make very sure you don't leave the bottle or any evidence of what was used- or even better leave something like aspirin.
Despite my own failure I had a friend use this method very successfully. If you have access to fentanyl- especially the patches use that instead.
Forgot one thing- I made some changes to my plans, but ran out of access to propranolol before I could implement them. Taking the number of pills necessary seems to be a problem and caused the majority of the issues with this method. Grind them up, put the full amount into just a few capsules. You can get empty ones at health food stores. This allows greater surface area for faster absorption and an above lethal dose quickly.

I'm pretty sure the only way to not get caught is to survive it, not tell anyone, and don't go to the hospital for help. They'll take your blood if you ask for help or if you ctb and it will be in there. I wish you the best.

 

[efffervescence]

how's your heart?

I had the exact same experience, ended up on ecmo life support
Took 4.3g, half a bottle of wine
I'm 5'9, 65kg

 

[WolfgangA]

For a life-threatening drop in blood pressure: Propranolol+Verapamil or maybe Viagra+Nitroglycerin.

There are many possible combinations.

Try using verapamil if you can't get digoxin. Where I live it's way easier to get. Not sure about where you live. Digoxin lowers the heart rate but so does verapamil. It's a calcium channel blocker. A calcium channel blocker and a beta blocker like Propranolol are a dangerous combination in lowering blood pressure quickly to a fatal level.

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journals.sagepub.com

Here are another two sites on the verapamil Propranolol combo:

Treatment of poisoning caused by β-adrenergic and calcium-channel blockers

Abstract. Purpose. The toxic effects and treatment of β-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed.Summary. Overdoses with cardi

academic.oup.com

Calcium Channel Blocker Overdose

At 2145 hours, 911 was contacted by an agitated male advising that his girlfriend was unconscious after having overdosed on some pills. On arrival, EMS found a 29-year-old female awake and alert. The patient admitted having taken 90 tablets of 180 mg tablets of verapamil Slow Release (SR). She...

www.jems.com

What would be an ideal dose for each if using a combo of Propranolol+Verapamil ?
Thoughts on this combo: Digoxin+Propranolol+Verapamil ? This 3 drug combo, does it have any negative interaction?

And what about adding Benzo's, maybe Midazolam and/or Diazepam and possibly adding in Alprazolam (Xanax) and/or Nortriptyline with the drug combinations mentioned above? I know from the DDMP that Diazepam should be fine with Digoxin+Propranolol but what about other drugs mentioned above?

Drink some alcohol afterwards maybe.

 

[FrankieMay]

how's your heart?

Physically? I'm absolutely fine, might be because I'm only 25 though
Emotionally: I was taken aback at the fact that life moves on, nothing has changed and no one even noticed. Silly I know

 

[efffervescence]

Physically? I'm absolutely fine, might be because I'm only 25 though
Emotionally: I was taken aback at the fact that life moves on, nothing has changed and no one even noticed. Silly I know

I'm only 19 and my heart is fucked up from it :( Emotionally Im pretty much unaffected too

 

[KnightOfEnceladus]

I've got a bottle of at least 100 20mg tabs from 2017, which should still be mostly potent. No access to anti-nausea meds other than dramamine unfortunately. And a small 100mL bottle of tert-amyl alcohol coming in the mail soonish, with any luck.

Will this be enough? I unfortunately can't get metoclopramide, verapamil, or any other prescription med. 30mL of TAA is said to be lethal and I'll be taking the full 100.

 

[Allpainnogain]

I've got a bottle of at least 100 20mg tabs from 2017, which should still be mostly potent. No access to anti-nausea meds other than dramamine unfortunately. And a small 100mL bottle of tert-amyl alcohol coming in the mail soonish, with any luck.

Will this be enough? I unfortunately can't get metoclopramide, verapamil, or any other prescription med. 30mL of TAA is said to be lethal and I'll be taking the full 100.

Don't know I'm sorry but where did you get the alcohol

 

[KnightOfEnceladus]

Off a common e-commerce site everyone uses. According to the psychonaut wiki at https://psychonautwiki.org/wiki/2M2B a dose of 30mL has been lethal. I'm 5'10" and just over 155lb, so 100mL of this alone ought to do it, but I figure by combining three depressive effects--the TAA's GABAergic powers, a shedload of beta-adrenergic antagonism from the propranolol, and some centrally-active H1 and muscarinic antagonism from, say, 2-6 doses of benadryl, the synergy should be very powerful.

Would appreciate advice from someone with more pharmaceutical expertise than me though.

 

[WolfgangA]

Without anti-emetics chances of vomiting is rather high or in other words increased chances of failure.

 

[Allpainnogain]

can you order this?

Buy Primperan for nausea 0 items on Bonanza

Found no results for this search query.

www.bonanza.com

 

[KnightOfEnceladus]

@Allpainnogain: possibly. I don't have the money yet, and a package of pills arriving for me would look very suspicious, but it seems like a safer bet to get it than not. I'm strapped for time, money, and privacy. Will need to see...

 

[BridgeJumper]

Im stockpiling on propranolol actually. This sounds promising.
Xanax doesnt do shit and I cant get heroin

 

[Allpainnogain]

Off a common e-commerce site everyone uses. According to the psychonaut wiki at https://psychonautwiki.org/wiki/2M2B a dose of 30mL has been lethal. I'm 5'10" and just over 155lb, so 100mL of this alone ought to do it, but I figure by combining three depressive effects--the TAA's GABAergic powers, a shedload of beta-adrenergic antagonism from the propranolol, and some centrally-active H1 and muscarinic antagonism from, say, 2-6 doses of benadryl, the synergy should be very powerful.

Would appreciate advice from someone with more pharmaceutical expertise than me though.

What is the site?

 

[KnightOfEnceladus]

@BridgeJumper1994: If you have a lot of Xanax I'd love to take them off your hands, if that's not criminal.

@Allpainnogain: Amazon, of course. The stuff can be used for synthesis reactions, IIRC, which is the context in which I'd first heard of tertiary alcohols anyway.

 

[Calculator321]

guys I think @J F succeeded this method.Hope he found peace.

 

[FrankieMay]

I'm only 19 and my heart is fucked up from it :( Emotionally Im pretty much unaffected too

Oh no what happened to your heart? Nothing serious I hope. Look after yourself

 

[efffervescence]

Oh no what happened to your heart? Nothing serious I hope. Look after yourself

40 mins of manual chest compressions and cardiac arrest. Thank you <3

 

[Fr2]

Sorry, I will make a lot of questions here, but I'm overwhelmed by the amount of information and my brain is not in a good enough state to process that much. The anxiety makes everything blurry, and it doesn't go away, only worsens lately.

What if i grind all my propranolol pills and mix them with water and drink the water? Does this somehow lessen their efficiency? Or maybe I can mix the grinded mass with other liquids too? Which liquid would be best?

I would also like to know, if i take 8-10 grams of propranolol, how much antiemetics do i have to take? And which antiemetics are best for nausea from propranolol?

How much verapamil is a good enough amount to count in this context?

 

[KnightOfEnceladus]

I would guess that crushing up the tablets and drinking in water would if anything make them work slightly faster. You'd need a huge antiemetic dose in any case; I think I've seen 60mg of metoclopramide recommended in other contexts, which is 6 good-size normal doses.

Verapamil acts on a different mechanism to produce the same effects; IIRC it is a class-IV antiarrythmic, a calcium-channel blocker, which directly acts on the action potentials of the heart itself, while propranolol is an early beta-blocker and acts by beta-adrenergic blockade (adrenaline and other similar neurotransmitters, collectively known as "catecholamines").

 

[laserfocus111]

Hi, I'm new to the forum. Seeking advice on CTB...

I am preparing
16g of propranolol (oral),
7.2g verapamil (30 days worth)
IV metoclopramide (150mg, 10 vials),
IV dormicum 150mg (10 vials)
IV fentanyl 0.3mg (6 vials)

don't ask me how I got it.


Plan
Crush and dissolve propranolol and verapamil in 1 cup.
Set up IV line
Drink solution and start drip (in 500ml normal saline).
Idea is for respiratory depression and bradycardia / hypoperfusion to do its magic.


Anyone thinks this is a solid plan? Any comments/suggestions?

 

[Sunset Limited]

Hi, I'm new to the forum. Seeking advice on CTB...

I am preparing
16g of propranolol (oral),
7.2g verapamil (30 days worth)
IV metoclopramide (150mg, 10 vials),
IV dormicum 150mg (10 vials)
IV fentanyl 0.3mg (6 vials)

don't ask me how I got it.


Plan
Crush and dissolve propranolol and verapamil in 1 cup.
Set up IV line
Drink solution and start drip (in 500ml normal saline).
Idea is for respiratory depression and bradycardia / hypoperfusion to do its magic.


Anyone thinks this is a solid plan? Any comments/suggestions?

It may be better to use SN instead of propranolol. Of course I assume you have access to SN. I have a similar plan. I will inject 2000 mg of propofol 5-10 minutes after I drink SN. I don't know much about midazolam. If midazolam will knock you down, it's a good combination with SN. According to the information I read here and beta blocker overdose case reports, it's a slow process. A large dose of 16 grams, but I still don't know if it speeds up the process. I am aware that I cannot help much. I hope it will be a peaceful exit, man. I think you have the necessary medicines for this.

Edit: I think 150 mg metoclopramide is too much. Of course, this is still not an expert opinion but it can cause very unpleasant side effects.

 

[GoodPersonEffed]

It may be better to use SN instead of propranolol. Of course I assume you have access to SN. I have a similar plan. I will inject 2000 mg of propofol 5-10 minutes after I drink SN.

I'm curious as to why you think SN would be better than propanolol.

Also curious as to why you would take propfol so long after ingesting the SN.

 

[Sunset Limited]

I'm curious as to why you think SN would be better than propanolol.

Also curious as to why you would take propfol so long after ingesting the SN.

Actually SN is not better but faster process but still, if we consider that SN will knock down someone after 12 - 15 minutes, maybe we can say better. So, after 15 minutes, the unconsciousness is certain.

Propofol works as fast as an arm and brain circulation but at the same time, its effect is very short. Although the awakening time is very variable with 200 mg propofol dose used in anesthesia induction, it is about 6 - 12 minutes. In fact, when the symptoms of SN poisoning start to bother me, I plan to inject the propofol. So even if the effect of propofol ended after 10 minutes, SN will knock me down. So if I inject propofol after a few seconds of drinking SN, there is a possibility of waking up without SN knock me down.

I don't think I will wake up after 10 minutes with 2000 mg propofol :). But I still don't want to take risks. I couldn't decide how to inject yet. I can inject 2000 mg in 1 minute but this is not guaranteed to cause 100% cardiovascular collapse. That's why I can choose to be unconscious with 600 mg bolus + 1400 mg drip system infusion of propofol until SN kills me . I still couldn't decide :)

 

[can'tdoitanymore]

I've had a few propranolol overdoses mixed with alcohol and xanax. 7.2grams propranolol and I think 90mg xanax. First time I did not vomit but was found within 20 mins. I stopped breathing and was intubated and unconscious for a little over 48 hours. Second time wasn't found for 26ish hours. Ended up intubated and in a coma for 4 days in critical condition. My family was told I might not make it through the night. Apparently very low o2 levels, very pale, had aspiration pneumonia and a collapsed lung (I think from falling so hard - propranolol OD makes you faint). I had removed the labels from the bottles so they wouldn't know what I had taken if I was found alive. I found out I was given Narcan by EMTs because of how pale and unreponsive I was they suspected it was an opioid overdose. When I had to go back to the ER (I discharged AMA from ICU and still had pneumonia) they were shocked I was firstly alive and secondly not brain damaged. Caused a lot of pain from falling for months, the chest tube for the collapsed lung was the worst pain I've ever experienced and I kept feeling weak and fainting for several weeks which only caused more problems because I ended up with concussions and staples in my head. Third time I just vomited it all up and was found 30+ hours later unresponsive and had severe nerve damage which is the second most painful thing I have experienced. I would advise against it. It will definitely harm you but your body will try and throw it up and if you survive can cause lasting damage. I used Zofran during the last attempt before I knew the right kind of anti-emetics.