M
myopybyproxy
flickerbeat \\ gibberish-noise
- Dec 18, 2021
- 864
NB: Please note that any responses to this ought not be considered spurring or encouraging suicide - just providing factual information for consenting adults to do with as they please. If you're uncomfortable providing or witnessing the exchange of such information, kindly exit the page. I will do this whether you offer your input or not - merely trying to sort out the details and determine the lowest risk of failure and fucking up my life.
I aim to combine CNS depression from polysubstance intake with a mechanical method - debating between jumping (20 metres, water below), lying down before a train, and either shallow water or regular drowning (post-substance intake). Only learnt of SWD recently from this site - so my knowledge is limited - seen posts saying alcohol etc would be counterproductive as the goal in SWD is hyperventilating. Wouldn't a stimulant such as coke or meth/amfetamin help in that case?
Hopefully someone with greater pharmacokinetic understanding than I will chime in regarding the inducers and inhibitors aspect. Responses from anyone with a modicum of reasoning ability welcome - which method combination (of the possibilities I mention herein) do you think would be most effective and why? Thank you in advance.
Currently leaning toward regular drowning as that involves no competing mechanisms - as seems to be the case with SWD - and there is lesser likelihood of interference (jump site is along train route - in either case, too many people around - unless I go at an odd hour). My only qualm with that is that the water will be freezing - temperature here has been -3 degrees or lower - highest recently was 8 and that was at midday. I fear that I will get one cm of skin wet and turn tail. At least with jumping there is no going back once your feet leave the platform. I hate to admit, but I am a coward - I don't believe I would actually make the jump.
Relevant inducers and inhibitors - items with asterisk are ones to which I have especial access and thus interest:
Cannabidiol - CYP2D6 inhibitor, avoid starting at T-4320, reintroduce at T-20 (?) ROA depending
*Glutathione - CYP2D6 inducer and CYP3A4 inhibitor, investigate further
Vitamin D - CYP3A4 inducer, avoid starting at T-4320
Pomegranate juice - CYP3A4 inhibitor
Starvation - CYP3A4 inducer, avoid beyond T-4320
Valerian - CYP3A4 inhibitor, investigate further
Vitamin B3 (niacin/amide) - CYP3A4 inhibitor and CYP2D6 inhibitor
*Trazodone - CYP3A4 substrate, investigate further
My proposed schedule is as follows. Items in bold are those I have not yet obtained - whole or in part. Time counts backward in minutes from the moment of last action.
T-4320 grapefruit juice 200mL thrice daily (CYP3A4 inhibitor)
T-80
I aim to combine CNS depression from polysubstance intake with a mechanical method - debating between jumping (20 metres, water below), lying down before a train, and either shallow water or regular drowning (post-substance intake). Only learnt of SWD recently from this site - so my knowledge is limited - seen posts saying alcohol etc would be counterproductive as the goal in SWD is hyperventilating. Wouldn't a stimulant such as coke or meth/amfetamin help in that case?
Hopefully someone with greater pharmacokinetic understanding than I will chime in regarding the inducers and inhibitors aspect. Responses from anyone with a modicum of reasoning ability welcome - which method combination (of the possibilities I mention herein) do you think would be most effective and why? Thank you in advance.
Currently leaning toward regular drowning as that involves no competing mechanisms - as seems to be the case with SWD - and there is lesser likelihood of interference (jump site is along train route - in either case, too many people around - unless I go at an odd hour). My only qualm with that is that the water will be freezing - temperature here has been -3 degrees or lower - highest recently was 8 and that was at midday. I fear that I will get one cm of skin wet and turn tail. At least with jumping there is no going back once your feet leave the platform. I hate to admit, but I am a coward - I don't believe I would actually make the jump.
Relevant inducers and inhibitors - items with asterisk are ones to which I have especial access and thus interest:
Cannabidiol - CYP2D6 inhibitor, avoid starting at T-4320, reintroduce at T-20 (?) ROA depending
*Glutathione - CYP2D6 inducer and CYP3A4 inhibitor, investigate further
Vitamin D - CYP3A4 inducer, avoid starting at T-4320
Pomegranate juice - CYP3A4 inhibitor
Starvation - CYP3A4 inducer, avoid beyond T-4320
Valerian - CYP3A4 inhibitor, investigate further
Vitamin B3 (niacin/amide) - CYP3A4 inhibitor and CYP2D6 inhibitor
*Trazodone - CYP3A4 substrate, investigate further
My proposed schedule is as follows. Items in bold are those I have not yet obtained - whole or in part. Time counts backward in minutes from the moment of last action.
T-4320 grapefruit juice 200mL thrice daily (CYP3A4 inhibitor)
T-80
- two eggs, avocado, two white grapefruits with fibre, 1.48g black pepper (211mg x 7), 1.42g turmeric (284mg x 5) (CYP3A4 inhibitors, increased bioavailability of lipophilic substances)
- 200mL white grapefruit juice with pulp (CYP3A4 inhibitor)
- 250mL quinine / tonic water (CYP2D6 inhibitor, lengthens QT interval)
- 4mg ondansetron x 1 (3 flip 5) (30 min til comeup, 2hr til peak) (CYP2D6 and CYP3A4 substrate)
- travel (it takes about 60 minutes entirely by foot to get to my proposed location - all potential methods are in roughly the same area - 25 minutes cycling - however, some walking is required due to fence enclosure)
- 800mg cimetidine 200mg x 4 po (35 min til comeup, 2hr til peak) (weak CYP3A4 and CYP2D6 inhibitor)
- 500mg naproxen x 1
- 50mL bismuth subsalicylate
- 4mg ondansetron x 1 (CYP2D6 and CYP3A4 substrate)
- 200mL white grapefruit juice with pulp (CYP3A4 inhibitor)
- 250mL quinine / tonic water (CYP2D6 inhibitor, lengthens QT interval)
- 150mL bismuth subsalicylate
- 30mg dextromethorphan HBr 5mg x 6 (CYP2D6 and CYP3A4 substrate)
- 50mg dimenhydrinate 50mg x 1
- 24mg chlorpheniramine maleate 4mg x 6 (CYP2D6 and CYP3A4 substrate)
- 50mg diphenhydramine 25mg x 2 (CYP2D6 inhibitor)
- 3.3g sodium bicarbonate 550mg x 6 (taken now so as not to interfere with food digestion, but to prepare pH to decrease body's ability to excrete the pills)
- remainder bismuth subsalicylate
- 300mg morphine or equivalent (290mg po, 30mg rectal - 15mg in 3mL x 2 syringe) (CYP3A4 and CYP2D6 substrate)
- 20mg oxycodone 10mg x 2
- 300mg oxycodone 30mg x 10
- 370mL (360 scale grams) 80 proof ethanol (330mL po, 40mL rectal) tampon (to prevent expulsion and insure absorption)
- 40mg alprazolam 2mg x 10 po (CYP3A4 substrate)
- 2mg alprazolam 1mg x 2 po (CYP3A4 substrate)
- 4mg clonazepam 2mg x 2 (15 min til comeup, 1 hour til peak) po (CYP3A4 substrate)
- 10 breaths hyperventilate - if regular drowning chosen, stand waist-deep so as to reduce the time necessary to swim
- 2g fentanyl (uncertain as to exact quantity of active ingredient, hence the large amount - much is filler - 2g quota of which I have 1.05g powder comprised of separate batches that each tested F+) whilst holding breath iv 2.5 mL (two rigs) (CYP3A4 and CYP2D6 substrate)
- jump into water / before train / swim