Resource Butanediol megathread

[gingerplum]

@lifeisbutadream mentions in a different thread that the October edition of PPEH says that Dim./dramamine can be used if you can't get the stronger antiemetics (for N I'm guessing?). if so then maybe it could work here... unfortunately I can't check what exactly the edition says because it's not opening for me :/

Ok, ok... I guess. Grudgingly. It's tantamount to substituting roller skates for a Tesla. Sure, it'll get you there, but you're probably in for a much bumpier ride.

Dramamine is Benadryl (Diphenhydramine) with a caffeine-like stimulant in it. So, bottom line is, it's an antihistamine, not an antiemetic, no matter what you call it.

My understanding of Dramamine is that it works for nausea specifically secondary to inner ear imbalance, ie motion sickness.

The upshot is yes, it's better than nothing, but with meto available as Primperan on eBay, I'd go with that.

 

[Arak]

Note: https://en.m.wikipedia.org/wiki/GABAB_receptor and https://en.m.wikipedia.org/wiki/GABAA_receptor

After giving this one more thought. I still don't know what to make of it. Sources tend to suggest that it acts on the GABAB and GHB receptor.
If only the effect on GABAB were revevant, would it not be comparable to an overdose of baclofen ?

The karger article 'GHB acts mainly via a bidirectional effect on GABAB receptors (GABABR; subunits GABAB1 and GABAB2), depending on the subunit of the GIRK (G-protein-dependent ion inwardly rectifying potassium) channel involved, and an indirect effect of the cortical and limbic inputs outside the nucleus accumbens. GHB also activates a specific GHB receptor and β1-subunits of α4-GABAAR. Reversing this complex interaction of neurobiological mechanisms by the abrupt cessation of GHB use results in a withdrawal syndrome with a diversity of symptoms of different intensity, depending on the pattern of GHB abuse. Conclusion: The GHB withdrawal symptoms cannot be related to a single mechanism or neurological pathway, which implies that different medication combinations are needed for treatment'

That's more complicated. A complicated article: https://www.sciencedirect.com/science/article/pii/S0028390814003037
I'm not sure what to make of the two GABAB subunits.

But it appears to act on GABAB, GHB, and alpha4gamma1 of GABAA.


Well, I got at least two questions: is anyone able to make more sense of this than I can and to what extent is baclofen comparable with GHB for our purpose ?

 

[Toenditall]

I'm so happy it all turned up I can finally leave this shitty world my date is this Sunday as I have 3 days of work in a row and it will give them time to sort out the staff cheers for the help might do a little tester tonight to see what ghb is like

 

[TiredHorse]

Can you pm me the link you used all I can find it in is plastic bottles, I'd rsther have glass. Thanks

@Moms_Spaghetti, I've posted the link somewhere around here, but here it is again:
https://www.amazon.com/gp/product/B07JPJPDF1/ref=oh_aui_detailpage_o00_s00?ie=UTF8&psc=1

 

[TiredHorse]

Awesome, thank you. Have you tried anymore btw? Any side effects at all?

I have not tried any more. All indications are that 1) it's highly addicitve, and 2) you can build up a tolerance to it. Since I have no interest in fighting an addiction as well as depression, and since I build a tolerance to pretty much anything absurdly quickly, I won't be doing further experimentation. However, @Itstimeforpeace and @Toenditall have posted some of their results over in the Butanediol Notice thread --which seems to have usurped this thread in terms of current acquisitions and experimentations.

My experience with a very small quantity included --aside from rather unpleasant taste, which I have come to understand probably is only so unpleasant to me because I don't drink at all-- some tightness in my chest that began fairly soon (~30 min?) after ingestion, then my mood lightened considerably for about 90 min. My improvement in mood tapered off farly quickly, and did nothing to minimize / buffer the emotional impacts of several "triggering" encounters I had with internet material while web browsing post-dose. The tightness in my chest continued for several hours, gradually diminishing, and it could well have been attributable to stress rather than the 1,4B itself. I woke without any hangover, though my morning gloom did seem especially unpleasant this morning. Itstimeforpeace's experience was much more dramatic, and Toenditall will hopefully also soon be posting some results.

So far, I'd have to say that it looks like a very, very viable method. A hefty dose of 1,4B mixed into an alcoholic cocktail to both enhance the effects and blunt the flavor --daiquiries, anyone?-- could turn out to be the "Budget N."

 

[Jadon91]

Strange study...

/CASE REPORTS/ 15 or 30 g of 1,4-butanediol (0.21 or 0.43 g/kg bw) was rectally administered to 7 patients. After 10 to 20 minutes, the patients became /comatose/ after deep unconsciousness, miosis and complete areflexia and this condition continued for 1 to 16 hr. Two of them died within 72 hours after the administration, but other five patients recovered naturally or after treatment with analeptic. Sustained disorder was not observed. Renal disorder was found on two /dead/ patients.
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1112

What about this study?
Unfortunately it is not very clear, but that "within 72 hours" a little 'scares me.
The other 5 patients appear to have been treated with medical care.