Opioid Megathread & Overview

[JoysoftheEmptiness]

Thank you for taking the time for writing at such length.

The only reason I added Mirtazapine was because I kept seeing on various post including this particular drug.

Much appreciated.

I overdosed on Mirtazapine, didn't manage to CTB, but I was really ill after that. Dislike overdosing on anything now.

 

[sg95]

I have acquired about a gram of Fentynal and am looking to use this as my method.
My question is what method is best. I would prefer oral ingestion but concerned about vomiting it up. Then, IV. (...nasal sounds horrible)

I have 2 concerns:
- Oral: What is the onset in to unconciousness?
- IV: How much could I feasibly fit in a single insulin needle?

 

[sleepforever81]

How much tramadol is the fatal dose.

 

[Rhizomorph1]

I have acquired about a gram of Fentynal and am looking to use this as my method.
My question is what method is best. I would prefer oral ingestion but concerned about vomiting it up. Then, IV. (...nasal sounds horrible)

I have 2 concerns:
- Oral: What is the onset in to unconciousness?
- IV: How much could I feasibly fit in a single insulin needle?

Aqueous solubility of fentanyl = approximately 1,300mg/mL according to this information sheet.

So, if your insulin syringe contains 1mL of water (preferably distilled water), you can put up to 1.3 grams of 100% pure fentanyl in it. If you have a larger syringe (e.g., 3mL syringe), you just multiply the 1,000 figure by the number of mL (e.g., 3x1,300 = 3,900mg or 3.9 grams).

However, it's incredibly unlikely your fentanyl is 100% pure. I used to do drug checking analysis with a spectrometer and only saw samples above 30% concentration on one or two occasions.

The average concentration in the illicit drug supply is around 15% so you likely have about 150mg (give or take) in your whole 1 gram sample. The only way to know for sure is to test it using a spectrometer at a drug checking/harm reduction location.

Also, I have no idea what the solubility of the other cutting agents and buffs (usually some citric acid & an inert sugar like mannitol) are, which means you could risk clogging up your syringe with massive amounts of substance. This is unlikely but may be added reason to get a syringe with a larger-than-necessary volume (3-10mL would be suitable)

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The oral onset will take between 20 minutes to a 2 hours depending on your metabolism, how much you've eaten, etc. following the SN protocol is the best bet, simply replacing the SN with your opioid. However, opioids are notorious nauseants meaning the risk of vomiting and CTB failure with oral administration is astronomically higher, even with an antiemetic. This is why I can *NOT* recommend oral consumption in good faith; the bioavailability is already far lower than other routes, and the risk of injury and ctb failure is high.

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[/HR

The other reliable administration option (but still unreliable method overall for the reasons discussed in the OP) is rectal administration using an oral syringe inserted about 1-2 knuckles length past the rectum; if anyone reading has a needle phobia, has trouble finding a vein, etc.

How much tramadol is the fatal dose.

I'm uncertain but I would highly recommend against using tramadol as the serotonergic activity is bound to cause adverse side effects, and it almost unanimously comes in pill form which is almost impossible to inject; read the comment above for issues regarding vomiting.

I would be highly surprised if someone successfully ctb with tramadol or other weak opioids (e.g., codeine).

The risk of injury without successful ctb is high, especially given the added serotonin activity (serotonin syndrome; non-fatal seizures, vomiting, tremors, hallucinations, agitation, neuromuscular pain, etc.)

 

[Ugory]

Rhizomorph1

Hi
You recommend rectal ROA. But 1 gr of methadone doesn't dissolve in 1 ml of water..

 

[Rhizomorph1]

Rhizomorph1

Hi
You recommend rectal ROA. But 1 gr of methadone doesn't dissolve in 1 ml of water..

Methadone has quite a long half life and attenuated peak blood concentration. Although it's a strong opioid it's specific pharmacokinetics makes it quite challenging to OD on compared to heroin, fentanyl, or oxy.

Just for consideration; I don't recommend it.

For rectal ROA you can use plenty more than 1ml. Use however much necessary to dissolve your drug (I still don't recommend opioids, however; this info is only if you decide to do it despite the moderate reliability)

 

[justwannaleave]

Do you think snorting a high amount of heroin could lead to death? It's the easiest ROA for me.

 

[finishLana]

What are the risks if opioid is placed in an acid resistant enteric capsules, bypassing the stomach and released in the small intestine

 

[k1w1]

How much tramadol is the fatal dose.

Nothing....it is rubbish

 

[Rhizomorph1]

IDo you think snorting a high amount of heroin could lead to death? It's the easiest ROA for me.

It could. It could not.

The reliability is moderate so your chances of success are in the same ballpark as your chances of failure.

IV or rectal administration will always absorb quicker and more of the drug than snorting. A lot get clogged in the sinuses especially at high doses. I don't think insufflation is a very effective ROA for ctb.