Hi there, after researching much at my medication/substance thread, I will propose two relatively new methods and explain how each method works.
1. Amygdalin/Laetrile (Vitamin B17)+Vitamin C
I know there has been a thread about it before, but I'd explain it more detailed in here.
Explanation: This is basically improved method from using simple amygdalin to create cyanide in your body. This time it uses vitamin C as a compliment to it. Hydrolysis of the amygdalin molecule yields up to 6% (w/w) hydrogen cyanide (HCN), benzaldehyde, and glucose. Vitamin C not only might increase amygdalin hydrolysis mechanism, but also markedly decrease the body stores of cysteine, a sulfur-containing amino acid that facilitates the detoxification of cyanide [1,2,3].
Dosage: Oral intake of 500 mg of amygdalin may contain as much as 30 mg of cyanide. You may need as little as 1 gram of pure amygdalin taken orally combined with vitamin C to create 60 mg of cyanide, which is in the lethal dosage of cyanide itself. As for the vitamin C, regular vitamin C would do the trick better than extended ones. Extended vitamin C release them slowly rather than in an large burst like regular ones. Sudden increase in vitamin C would severely impact cyanide from amygdalin detoxification. Dose of vitamin C can varies, but it's recommended you take mega dose of it (>3 g)
Opinion: This is old but still underrated method of substance ctb. Not only is that both are still easy to obtain (although looks like amygdalin will more tightly regulated), but that the results would be same as cyanide poisoning, which is lethal and less agonizing imo. Just note that cyanide poisoning is also known to have an antidote so that this is also highly treatable at the same time.
2. Diphenhydramine (DPH)+Melatonin
Shout out to @LittleJem for this one. The sources are only one case report, so take it with a grain of salt
Explanation: Diphenhydramine functions by competing with histamine for H-1 receptor sites. Locations of these receptors can be found throughout the body; however, the ones located within the central nervous system are responsible for the sedative side effect. In addition, DPH acts on muscarinic receptors causing anticholinergic effects such as tachycardia, dry mouth, and blurry vision, which become more prominent at higher concentrations. In cases of increased concentration/toxicity (often doses >1.0 g), DPH can function as a blocker of the heart's rectifier potassium ion channels due to its anticholinergic activity. Melatonin further complicate this matter by lethargy, disorientation, and severe delayed hypotension in recorded cases
Dosage: This case shows that both the DPH and melatonin are above the toxic dose. In this case, 8 g of DPH and 480 mg of melatonin. There is no recorded minimal dose for both to work with.
Alternatives: Here's a case report of overdose benzos with melatonin. The report do say that benzos reduce the melatonin levels in blood though.
Opinion: Yeah I was torn with this one. I'd wager that the death in the case report is primarily due to DPH overdose, with melatonin only works in a lesser role since melatonin is having a large therapeutic range compared to DPH. Oh yeah and also the DPH dose taken way too high compared to the melatonin one.
Since I can only using case reports this is way too undeveloped to work, compared to methods like SN or the 5-drug mix. Therefore, I need everyone opinion on this one. Can it work? If so, can this be an alternatives to both older methods? Let me know in the replies below!
1. Amygdalin/Laetrile (Vitamin B17)+Vitamin C
I know there has been a thread about it before, but I'd explain it more detailed in here.
Explanation: This is basically improved method from using simple amygdalin to create cyanide in your body. This time it uses vitamin C as a compliment to it. Hydrolysis of the amygdalin molecule yields up to 6% (w/w) hydrogen cyanide (HCN), benzaldehyde, and glucose. Vitamin C not only might increase amygdalin hydrolysis mechanism, but also markedly decrease the body stores of cysteine, a sulfur-containing amino acid that facilitates the detoxification of cyanide [1,2,3].
Dosage: Oral intake of 500 mg of amygdalin may contain as much as 30 mg of cyanide. You may need as little as 1 gram of pure amygdalin taken orally combined with vitamin C to create 60 mg of cyanide, which is in the lethal dosage of cyanide itself. As for the vitamin C, regular vitamin C would do the trick better than extended ones. Extended vitamin C release them slowly rather than in an large burst like regular ones. Sudden increase in vitamin C would severely impact cyanide from amygdalin detoxification. Dose of vitamin C can varies, but it's recommended you take mega dose of it (>3 g)
Opinion: This is old but still underrated method of substance ctb. Not only is that both are still easy to obtain (although looks like amygdalin will more tightly regulated), but that the results would be same as cyanide poisoning, which is lethal and less agonizing imo. Just note that cyanide poisoning is also known to have an antidote so that this is also highly treatable at the same time.
2. Diphenhydramine (DPH)+Melatonin
Shout out to @LittleJem for this one. The sources are only one case report, so take it with a grain of salt
Explanation: Diphenhydramine functions by competing with histamine for H-1 receptor sites. Locations of these receptors can be found throughout the body; however, the ones located within the central nervous system are responsible for the sedative side effect. In addition, DPH acts on muscarinic receptors causing anticholinergic effects such as tachycardia, dry mouth, and blurry vision, which become more prominent at higher concentrations. In cases of increased concentration/toxicity (often doses >1.0 g), DPH can function as a blocker of the heart's rectifier potassium ion channels due to its anticholinergic activity. Melatonin further complicate this matter by lethargy, disorientation, and severe delayed hypotension in recorded cases
Dosage: This case shows that both the DPH and melatonin are above the toxic dose. In this case, 8 g of DPH and 480 mg of melatonin. There is no recorded minimal dose for both to work with.
Alternatives: Here's a case report of overdose benzos with melatonin. The report do say that benzos reduce the melatonin levels in blood though.
Opinion: Yeah I was torn with this one. I'd wager that the death in the case report is primarily due to DPH overdose, with melatonin only works in a lesser role since melatonin is having a large therapeutic range compared to DPH. Oh yeah and also the DPH dose taken way too high compared to the melatonin one.
Since I can only using case reports this is way too undeveloped to work, compared to methods like SN or the 5-drug mix. Therefore, I need everyone opinion on this one. Can it work? If so, can this be an alternatives to both older methods? Let me know in the replies below!
