https://academic.oup(dot)com/jat/article/39/6/486/756583 I put the dot in it so the link doesn't lead back to here.
The drug itself is a painkiller that is used rather than prescribing co-codamol. Nefopam is approximately 10 times more potent than aspirin and 2 to 3 times less potent than morphine. The upshot is that it is toxic, although the death itself may not be as peaceful as one would imagine and unfortunately death can take up to a couple of days if you're found or haven't taken enough to kill you quickly.
It looks like so few people try to OD on this that there's not a lot of literature about it.
From reading the literature (and I am neither a doctor or a chemist, so I could be completely wrong in my understanding and the guesstimate),
Taking 3 tablets (90mg) gives a plasma concentration of .15.
The minimum any of the deaths recorded was 4.3 (approx 90 tablets) but this is a drug where weight determines toxicity. As an aside, if you were a dog you'd need somewhere between 100-200mg per kilo (3-7tablets)
As you can see from the image, survivors had all taken under 60 tablets. In the UK they come in a box of 90, which is one month's supply.
The good news is that according the the BMJ article, if you are found and treated you seem to recover without any adverse affects.
The drug itself is a painkiller that is used rather than prescribing co-codamol. Nefopam is approximately 10 times more potent than aspirin and 2 to 3 times less potent than morphine. The upshot is that it is toxic, although the death itself may not be as peaceful as one would imagine and unfortunately death can take up to a couple of days if you're found or haven't taken enough to kill you quickly.
It looks like so few people try to OD on this that there's not a lot of literature about it.
From reading the literature (and I am neither a doctor or a chemist, so I could be completely wrong in my understanding and the guesstimate),
Taking 3 tablets (90mg) gives a plasma concentration of .15.
The minimum any of the deaths recorded was 4.3 (approx 90 tablets) but this is a drug where weight determines toxicity. As an aside, if you were a dog you'd need somewhere between 100-200mg per kilo (3-7tablets)
As you can see from the image, survivors had all taken under 60 tablets. In the UK they come in a box of 90, which is one month's supply.
The good news is that according the the BMJ article, if you are found and treated you seem to recover without any adverse affects.
