I can obtain 100 10 mg oxycodone hydrochloride and I have 30 mg of Ativan. How much of this do I take to successfully ctb.
RoseGirl
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- May 8, 2025
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tapetum_lucidum
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- Mar 12, 2023
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RoseGirl
Student
- May 8, 2025
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R. A.
But...the future refused to change.
- Aug 8, 2022
- 1,404
Here's data safety sheet about oxycodone:
Lethal dose 50% (LD50) for oxycodone in mouse with oral intake is 482 mg/kg. Now if we use transferring method (mentioned here https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/), we can found that human equivalent dose (HED) for that is:
HED (mg / kg = 482 × 0.081 (mouse to human transition dose) = 39.042 mg / kg.
Same as ativan (lorazepam), here's the data safety sheet:
Lethal dose 50% (LD50) for lorazepam in mouse with oral intake is 1850 mg/kg. Now if we use the same transferring method, we can found that human equivalent dose (HED) for that is:
HED (mg / kg = 1850 × 0.081 = 149.85 mg / kg.
Now you can multiply that with your bodyweight and that's how much you should take. For instance, if you have 75 kg bodyweight you should take oxycodone around 2928,15 mg of oxycodone and/or 11238,75 mg of lorazepam. Since your stock of Ativan isn't near enough as needed, I'd suggest focus on oxycodone by stocking them up first. Now do note:
1. These are only calculation. In my opinion, the dose needed to ctb would be way lower than the predicted dose by animals. Even in the calculation paper they included notes that larger animals need far lower dose to achieve the same effect due to larger differences in the physiological process.
2. These are lethal dose 50%, meaning at that dose only 50% of the population of the samples died after ingesting the substance. Same as the transitioned dose. You could be in the upper half or lower half of the 50%. Same as many others, you should try your tolerance with the drug before you truly want to ctb
3. I think your ativan might be useful for you to turn off your SI and not as ctb method. Focus your method on oxycodone since you have bigger stocks of it.
Tldr: Use ativan, wait for it to slowly take effect, then ctb using all of your oxycodone stocks (if you can). Remember to prepare it thoroughly.
Here's the estrogen data safety sheet:
LD50 for mouse in intravenous injection is 1740 mg/kg. With the same calculation as above, we can extrapolate them by this:
HED (mg / kg = 1740 × 0.081 = 140.94 mg / kg.
Same notes as above, but do note ctb by estrogen is pretty rare and unheard of. Here's a case report of similar style if you're interested:
Pulmonary embolism due to exogenous estrogen intoxication - PubMed
We know that exogenous estrogen increase the risk of venous thromboembolism in therapeutic use. It should be kept in mind that even single ingestion of a single high-dose exogenous estrogen intake may induce pulmonary thromboembolism.
pubmed.ncbi.nlm.nih.gov
Sorry for not searching enough on testosterone. Data regarding testosterone toxicity is actually far harder to search than estrogen (don't ask me why lmao idk either). Here's one:we
In there they found LD50 for mouse with dermal injection is around 2000 mg/kg. With the same calculation we can make it's HED by:
HED (mg / kg = 2000 × 0.081 = 162 mg / kg.
Now do note that this calculation is extremely flimsy due to:
1. Its only made by using analogies related to the similar compound 4-Androstene-3,17-dione.
2. Still no case report of testosterone being used in ctb
3. The route is dermal injection, not straight up intravenous injection like in estrogen
4. All the points above about LD50 and precaution that this is only a calculation/speculation
Sorry for not searching enough on testosterone. Data regarding testosterone toxicity is actually far harder to search than estrogen (don't ask me why lmao idk either). Here's one:
In there they found LD50 for mouse with dermal injection is around 2000 mg/kg. With the same calculation we can make it's HED by:
HED (mg / kg = 2000 × 0.081 = 162 mg / kg.
Now do note that this calculation is extremely flimsy due to:
1. Its only made by using analogies related to the similar compound 4-Androstene-3,17-dione.
2. Still no case report of testosterone being used in ctb
3. The route is dermal injection, not straight up intravenous injection like in estrogen
4. All the points above about LD50 and precaution that this is only a calculation/speculation
Last edited:
RoseGirl
Student
- May 8, 2025
- 149
Freedombus'25
Hating every minute of being alive.
- Dec 8, 2019
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Can I PM you some questions regarding meds and such. I don't really feel comfy asking in public thread. No pressure or anything....
Human equivalent dose. Since studies on toxicology can't be done on humans (obviously), the dose acquired from test animals need to be adjusted to the human level.
Sure, why not? My DM are open.
What is your knowledge on a baclofen overdose? What is does, what it's like, and if it can actually work? I plan on consuming guanfacine as well.
First of all, I want to said I'm really sorry for the long wait. College stuff and irl conditions make me busy rn.
Converting table from this publication I mentioned: https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/. I think I'll needing this more later on so I'll just post it here lol.
Your question has 3 topics, here's how it goes:
1. Baclofen overdose
Here's a data sheet about baclofen:
LD50 for oral route in rat is 50 – 300 mg/kg. From the publication above we can make its HED into this:
HED = 50 x 0.162 = 8.1 mg/kg
HED = 300 x 0.162 = 48.6 mg/kg
So we can deduct that LD50 for oral route for human is around 8,1-48,6 mg/kg.
There is actually a lot of good publications about baclofen overdose. I pick one that's a really good publication about baclofen overdose, here goes:
Baclofen therapeutics, toxicity, and withdrawal: A narrative review - PMC
Baclofen is an effective therapeutic for the treatment of spasticity related to multiple sclerosis, spinal cord injuries, and other spinal cord pathologies. It has been increasingly used off-label for the management of several disorders, including ...
pmc.ncbi.nlm.nih.gov
This study explains the symptoms, effect, and treatment of baclofen overdose. In general, ingestion as little as 200 mg a day could cause toxicity with the symptoms of degradation of consciousness (hallucinations, confusion, tremor, catatonia) that could lead up to death. Here's a case report of alleged ingestion of 15 tablet of 20 mg baclofen that ended on his death:
2. Guanfacine overdose
Different from baclofen, there's not a lot of data regarding guanfacine. I couldn't even find guanfacine LD50 on any data safety sheet.
From what I found, not a lot of guanfacine overdose can make them fatal. Here's a pretty good publication reviewing cases of guanfacine overdose:
Delayed Signs and Symptoms of Extended Release Guanfacine Overdose in Two Adolescent Patients: Implications of Monitoring on the Psychiatry Unit - PMC
Guanfacine is a selective alpha-2a adrenoreceptor agonist that with overdose can cause symptoms ranging from mild sedation to coma, respiratory depression, hyporeflexia, hypotonia, bradycardia, and hypotension. Despite a well-defined and predictable ...
pmc.ncbi.nlm.nih.gov
Guanfacine poisoning resulting in transient ST-segment elevation: a case report - International Journal of Emergency Medicine
Background Guanfacine is an alpha-2 adrenergic agonist that decreases norepinephrine release and sympathetic outflow. With the increased use of guanfacine for attention-deficit hyperactivity disorder (ADHD), reports of guanfacine poisoning have also risen. Case presentation A 15-year-old male...
intjem.biomedcentral.com
In general, I can't really make a judgement of this one. I don't think this is a good method with such no cases of dying of this so far as I can search of.
3. Baclofen and Guanfacine
There's a potential interaction on this one, usually because guanfacine can make hypotension that also can be lowered by baclofen:
Baclofen and guanfacine Interactions - Drugs.com
A Moderate Drug Interaction exists between baclofen and guanfacine. View detailed information regarding this drug interaction.
www.drugs.com
Can they work together in case of ctb? I say maybe. I can't really have a firm answer since studies on that is so low.
Thank you so much for your response! I wanted to combine the two because I knew that they both could lower blood pressure but I was scared I didn't have enough baclofen (because it's not my prescription), but I actually have more than I thought, 980 mg. I'm not sure if I should just do the baclofen or not, because the guanfacine is all wonky with it being extended release.First of all, I want to said I'm really sorry for the long wait. College stuff and irl conditions make me busy rn.
View attachment 177789
Converting table from this publication I mentioned: https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/. I think I'll needing this more later on so I'll just post it here lol.
Your question has 3 topics, here's how it goes:
1. Baclofen overdose
Here's a data sheet about baclofen:
LD50 for oral route in rat is 50 – 300 mg/kg. From the publication above we can make its HED into this:
HED = 50 x 0.162 = 8.1 mg/kg
HED = 300 x 0.162 = 48.6 mg/kg
So we can deduct that LD50 for oral route for human is around 8,1-48,6 mg/kg.
There is actually a lot of good publications about baclofen overdose. I pick one that's a really good publication about baclofen overdose, here goes:
Baclofen therapeutics, toxicity, and withdrawal: A narrative review - PMC
Baclofen is an effective therapeutic for the treatment of spasticity related to multiple sclerosis, spinal cord injuries, and other spinal cord pathologies. It has been increasingly used off-label for the management of several disorders, including ...
This study explains the symptoms, effect, and treatment of baclofen overdose. In general, ingestion as little as 200 mg a day could cause toxicity with the symptoms of degradation of consciousness (hallucinations, confusion, tremor, catatonia) that could lead up to death. Here's a case report of alleged ingestion of 15 tablet of 20 mg baclofen that ended on his death:
2. Guanfacine overdose
Different from baclofen, there's not a lot of data regarding guanfacine. I couldn't even find guanfacine LD50 on any data safety sheet.
From what I found, not a lot of guanfacine overdose can make them fatal. Here's a pretty good publication reviewing cases of guanfacine overdose:
Here's also a case report of guanfacine overdose case report that maybe interesting to you:Delayed Signs and Symptoms of Extended Release Guanfacine Overdose in Two Adolescent Patients: Implications of Monitoring on the Psychiatry Unit - PMC
Guanfacine is a selective alpha-2a adrenoreceptor agonist that with overdose can cause symptoms ranging from mild sedation to coma, respiratory depression, hyporeflexia, hypotonia, bradycardia, and hypotension. Despite a well-defined and predictable ...
In general, the symptoms of guanfacine overdose is hypotension, impaired consciousness, and bradycardia. Some can be delayed if they are using extended release version of guanfacine (as upper publication makes it)Guanfacine poisoning resulting in transient ST-segment elevation: a case report - International Journal of Emergency Medicine
Background Guanfacine is an alpha-2 adrenergic agonist that decreases norepinephrine release and sympathetic outflow. With the increased use of guanfacine for attention-deficit hyperactivity disorder (ADHD), reports of guanfacine poisoning have also risen. Case presentation A 15-year-old male...
In general, I can't really make a judgement of this one. I don't think this is a good method with such no cases of dying of this so far as I can search of.
3. Baclofen and Guanfacine
There's a potential interaction on this one, usually because guanfacine can make hypotension that also can be lowered by baclofen:
Baclofen and guanfacine Interactions - Drugs.com
A Moderate Drug Interaction exists between baclofen and guanfacine. View detailed information regarding this drug interaction.
Can they work together in case of ctb? I say maybe. I can't really have a firm answer since studies on that is so low.
mob
Student
- Jul 19, 2023
- 149
I recently overdosed on 7.2g of bupropion (extended release, if it matters), was taken to the hospital, recovered within 3 days. Had no seizures.
My question is, since the lethal range goes from 6g (at least that's where it starts getting toxic) upwards, how much does a person have to take to certainly die from it?
I don't plan on OD'ing on bupropion again, I'm just curious.
My question is, since the lethal range goes from 6g (at least that's where it starts getting toxic) upwards, how much does a person have to take to certainly die from it?
I don't plan on OD'ing on bupropion again, I'm just curious.
This is very hard question because certain death after bupropion use is absolutely hard on. The numbers are really large on its range, because its definitely depends on what patient are we're talking about:
A 19-year-old woman died with an estimated bupropion overdose of 28.2 g and possible oxcarbazepine co-ingestion.:
A 19-Year-Old Woman with a History of Depression and Fatal Cardiorespiratory Failure Following an Overdose of Prescribed Bupropion - PMC
Patient: Female, 19-year-old Final Diagnosis: Poisoning by bupropion Symptoms: Altered mental status • cardiogenic shock • seizure Medication: — Clinical Procedure: — Specialty: Toxicology Management of emergency care Bupropion is a ...
pmc.ncbi.nlm.nih.gov
A 28 year old male with history of severe depression died after consumption of 30 300mg bupropion (9 g) extended release pills as a part of a suicidal attempt:
A 26-year-old man who ingested 23 g bupropion, developed seizures and hypoxia, and died 4 d after supportive intensive care:
This range is really large, even as small as 9 g and up to >20g of buproprion (and one with possible ingestion of other substance). I'd say your attempt of 7,2g can kill someone with different subject as you (age, height, gene, sex, or dietary usage). And extended release certainly matter in terms of denying the immidiate release of bupropion of toxic concentration into the body. I'd say you're lucky surviving that attempt.
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