Method DMSO increases transdermal absorption of substances to almost 100% (ideal for fentanyl/nitazenes)

[rotciv]

Transdermal absorption of fentanyl is already quite high but a solvent is always needed, DMSO increases absorption even further, perhaps very close to 100% bioavailability. If someone wants to investigate further or is a chemist, I think this is another way to go.

Pharmacology of DMSO

Dr. Stanley Jacob, the father of DMSO offers information on DMSO & MSM. DMSO (dimethyl sulfoxide), a potent scavenger of free radicals, was first introduced to the scientific community in 1963 by a research team headed by Stanley W. Jacob, MD.

www.dmso.org

Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs - PubMed

Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and...

pubmed.ncbi.nlm.nih.gov

"Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). This article reviews the mechanism of action of DMSO as a pharmaceutical penetration enhancer, the characteristics of the molecule that facilitate transdermal drug delivery, and studies of efficacy and safety. The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery."

PERCUTANEOUS ABSORPTION OF DICLOFENAC DIETHYLAMINE IN THE PRESENCE OF DIMETHYL SULFOXIDE

ABSTRACT The aim of present study was to evaluate the effect of various concentrations of dimethyl sulfoxide (DMSO) on transdermal absorption of 1% diclofenac diethylamine across full thickness, hairless rabbit skin using modified Franz diffusion

www.academia.edu

The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man - PubMed

The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man

pubmed.ncbi.nlm.nih.gov

"...Radio-labeled 4C hydrocortisone and testosterone were applied to human skin in acetone alone and in DMSO. Penetration quantitated by assaying the 14C appearing in urine for five days. Without DMSO, 12 times as much testosterone penetrated as hydrocortisone. DMSO increased the penetration of both steroids three-and-one-half times. The significance of these findings is discussed."

Fentanyl - Wikipedia

en.m.wikipedia.org

Bioavailability 92% (transdermal) 90% (intranasal) 50% (buccal) 33% (ingestion) 100% (intramuscular) 80% (inhaled) 100% (intravenous)

 

[Aprilfarewell4]

Transdermal absorption of fentanyl is already quite high but a solvent is always needed, DMSO increases absorption even further, perhaps very close to 100% bioavailability. If someone wants to investigate further or is a chemist, I think this is another way to go.

Pharmacology of DMSO

Dr. Stanley Jacob, the father of DMSO offers information on DMSO & MSM. DMSO (dimethyl sulfoxide), a potent scavenger of free radicals, was first introduced to the scientific community in 1963 by a research team headed by Stanley W. Jacob, MD.

www.dmso.org

Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs - PubMed

Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and...

pubmed.ncbi.nlm.nih.gov

"Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). This article reviews the mechanism of action of DMSO as a pharmaceutical penetration enhancer, the characteristics of the molecule that facilitate transdermal drug delivery, and studies of efficacy and safety. The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery."

PERCUTANEOUS ABSORPTION OF DICLOFENAC DIETHYLAMINE IN THE PRESENCE OF DIMETHYL SULFOXIDE

ABSTRACT The aim of present study was to evaluate the effect of various concentrations of dimethyl sulfoxide (DMSO) on transdermal absorption of 1% diclofenac diethylamine across full thickness, hairless rabbit skin using modified Franz diffusion

www.academia.edu

The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man - PubMed

The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man

pubmed.ncbi.nlm.nih.gov

"...Radio-labeled 4C hydrocortisone and testosterone were applied to human skin in acetone alone and in DMSO. Penetration quantitated by assaying the 14C appearing in urine for five days. Without DMSO, 12 times as much testosterone penetrated as hydrocortisone. DMSO increased the penetration of both steroids three-and-one-half times. The significance of these findings is discussed."

Fentanyl - Wikipedia

en.m.wikipedia.org

Bioavailability 92% (transdermal) 90% (intranasal) 50% (buccal) 33% (ingestion) 100% (intramuscular) 80% (inhaled) 100% (intravenous)

@nottinghams

 

[rotciv]

 

[LunarLight]

Super informative, as always.

@goodoldnoname923 you might be interested in that

 

[willitpass]

Isn't this the same substance the infamous "toxic lady" used to help her cancer pain that ultimately resulted in her death?

 

[rotciv]

Isn't this the same substance the infamous "toxic lady" used to help her cancer pain that ultimately resulted in her death?

The toxicity of DSMO is very low, compared with the substances used for ctb.. the LD50 in mice is above 10g/kg, which is an absurd amount.

 

[willitpass]

The toxicity of DSMO is very low, compared with the substances used for ctb.. the LD50 in mice is above 10g/kg, which is an absurd amount.

I don't believe it was the DSMO itself that killed her, I believe it was a situation like this where it enhanced the toxicity of other drugs in her system.

 

[rotciv]

https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1967.tb34904.x

Pharmacology of DMSO

Dr. Stanley Jacob, the father of DMSO offers information on DMSO & MSM. DMSO (dimethyl sulfoxide), a potent scavenger of free radicals, was first introduced to the scientific community in 1963 by a research team headed by Stanley W. Jacob, MD.

www.dmso.org

"...Djan and Gunberg24 studied the percutaneous absorption of 17-estradiol dissolved in DMSO in the immature female rat. These steroids were given in aqueous solutions subcutaneously or were applied topically in DMSO. Vaginal and uterine weight increases resulting from estrogen in DMSO administered topically were comparable to results obtained in animals in which the drugs were administered in pure form subcutaneously."

Pharmacologic and biochemical considerations of dimethyl sulfoxide - PubMed

DMSO has multiple known pharmacological properties. In addition to those referred to include: cryoprotective action, radioprotective effect, influence on serum cholesterol in experimental hypercholesteremia, and platelet aggregation antagonism. How the multiple properties of this chemical affect...

pubmed.ncbi.nlm.nih.gov

"...Weismann and colleagues [117] have shown that lysosomes can be stabilized with cortisone against many types of damaging agents. When cortisone was dissolved in DMSO, the dilution of cortisone necessary to protect the lysosome was reduced from 1:10 to 1:1000. It was suggested that DMSO might provide a vehicle that makes steroids more readily available to target tissues, thus resulting in reduced inflammation as evidenced by the experimental models described above."

Percutaneous absorption of two steroids dissolved in dimethyl sulfoxide in the immature female rat - PubMed

Percutaneous absorption of two steroids dissolved in dimethyl sulfoxide in the immature female rat

pubmed.ncbi.nlm.nih.gov

Dimethyl sulfoxide therapy in chronic skin ulcers. - PubMed - NCBI
"...This simple fact permitted them to realize the medicinal properties and therapeutic possibilities of this drug. Some 2 to 6 hours after application on the skin, it is distributed through the organism, and in the same period of time it reaches the highest blood levels...According to Professor Don C. Wood, of the School of Medicine of the University of Oregon, after DMSO has been applied, tissues either rich or poor in lipids contain the same amount of DMSO. The reason for this is unknown."


Pharmacologic and biochemical considerations of dimethyl sulfoxide. - PubMed - NCBI
"...Weismann and colleagues [117] have shown that lysosomes can be stabilized with cortisone against many types of damaging agents. When cortisone was dissolved in DMSO, the dilution of cortisone necessary to protect the lysosome was reduced from 1:10 to 1:1000. It was suggested that DMSO might provide a vehicle that makes steroids more readily available to target tissues, thus resulting in reduced inflammation as evidenced by the experimental models described above."

Percutaneous absorption of two steroids dissolved in dimethyl sulfoxide in the immature female rat. - PubMed - NCBI
"...The steroids were given to the animals either in an aqueous suspension s.c., or applied topically in DMSO. Vaginal and uterine weight increases resulting from estrogen stimulation, and thymus, spleen and adrenal involution resulting from the exogenous cortisone were comparable in animals subjected to the two routes of administration, with a few noted exceptions."

"...Because it has been demonstrated that 17-/3-estradiol will cross the cutaneous barrier in an ointment base, a group of animals were administered 0.4 pg of 17-P-estradiol in 0.5 ml of sesame oil, utilizing the same technique employed for the estrogen-DMSO-treated animals. Average vaginal weight response in these animals were comparable to those observed in animals administered 0.4 pg estradiol s.c. or 0.5 p estradiol topically in DMSO (FIGURE 1). It was necessary, however, to use dosages in oil. 2.5 greater than those administered in DMSO to obtain uterine weight increases of the same order."

"...Average body weight gains (+ 2.5 gm, +2.8 gm) and average adrenal weight (23.1 mg, 25.2 mg) were not significantly different for the two dosages employed in oil and are comparable to those obtained from animals treated S.C. with 1 mg of cortisone. In none of the parameters measured, except for body weight changes, did the topical ap- plication in oil approximate the figures obtained from animals treated in the same fashion with the steroid in DMSO."

"...At these concentrations, the use of undiluted DMSO is feasible and it has been demonstrated that undiluted DMSO is the most effective concentration for moving steroids across the skin barrier."

"...A comparison of the organ weight response to the topically applied steroids in the two solvents used in the experiments reported here, DMSO and sesame oil, indicates that DMSO most closely mimics the results obtained by S.C. administration of these compounds. It can be concluded that DMSO effectively transports 17-0-estradiol and cortisone acetate across the skin barrier in immature female rats and does not markedly reduce the effects of these two steroids on organ response when examined gravimetrically, if a minimal vol- ume of undiluted DMSO is employed."

 

[ThisGameIsOverrated]

which studies show the amount of DMSO ml used and the purity? I've got too much brain fog atm to look through everything myself so if you already have a source please lmk

 

[rotciv]

which studies show the amount of DMSO ml used and the purity? I've got too much brain fog atm to look through everything myself so if you already have a source please lmk

There no studies linked to DMSO and fentanyl/nitazenes. But you can order DMSO at 70% and 99% online.

 

[ThisGameIsOverrated]

on further research it seems relatively easy to just put a few ml of DMSO on the skin then like 60mg but that's the easy part. Now we need to know what depressant to combine it with for maximum results, you could try GBH so you sleep or you could try benzos but with benzos knowing how much to take and how much AEs is a big issue.

 

[rotciv]

I easily dissolved 500mg of Protonitazepyne in 2ml of DMSO, but seems it's too much liquid, I think it will almost look like I've been spreading tanner on the beach lol

It seems to me that a 1:2 ratio would be better, but I will continue to test.

 

[situationalsui]

Thanks for testing this. I'm looking into it too, to boof the solution if the zenes aren't water soluble. I did not know if I would trust a transdermal application.

 

[Nikitatos]

DMSO is powerful stuff. It will eat through any wood it touches, so be careful. I've used it with herbs/alternative healing stuff. It DEFINITELY works as advertised (increases transdermal absorption).

 

[EyesOfNight]

I easily dissolved 500mg of Protonitazepyne in 2ml of DMSO, but seems it's too much liquid, I think it will almost look like I've been spreading tanner on the beach lol

It seems to me that a 1:2 ratio would be better, but I will continue to test.

View attachment 138976

Try periodically adding more DMSO to the powder instead of the other way around. This way you will use less material and can reliably find the minimum amount of DMSO in which the powder will dissolve.

 

[Felodese]

Just made me think of this

 

[rotciv]

Try periodically adding more DMSO to the powder instead of the other way around. This way you will use less material and can reliably find the minimum amount of DMSO in which the powder will dissolve.

I mean I would but problably I will go just to ctb trying to get high because one drop is enough for a opioid naive like me lol

My work is done here.