Since the megathread has been closed, I report here.
This is what I found from 8chan.
1,4-butanediol OD:
1- Do not drink alcohol.
2- Take 30mg metoclopramide 1 hour prior.
3- Drink more than 50 ml 1,4-butanediol (99%).
* You may combine 1,4-BD with sedatives/hypnotics and opiate/opioid.
** You may drink 1,4-BD in orange or cranberry juice to mask the taste.
*** You may drink alcohol after starting to feel the effect of drug (when metabolized to GHB/GBL).
People have died with ~10g 1,4-BD (i.e.,10 ml 1,4-BD 99%). The symptoms are similar to alcohol intoxication.
It's hard to estimate the time of death because it depends on ADH1B genotype–but, based on elimination half-life–it'd take less than 6 hours.
Although drinking alcohol with 1,4-BD suppresses CNS, it's best not to do so, since alcohol acts as a competitive substrate to alcohol dehydrogenase. Further, to hasten death and prevent saturated metabolizm, 1,4-BD could be drunk in several shots leisurely. This way the chance of vomiting decreases for those who want to do it without anti-emetic. Ingesting 1,4-BD without anti-emetic might induce vomiting while still conscious, yet the outcome is most likely fatal.
Alternatives for 1,4-butanediol (GABA B), which are sold under several brand names, are Gamma-Butyrolactone, Glutamic acid, gamma-Aminobutyric acid, gamma-Valerolactone, 4-Fluorophenibut, Aceburic acid, GABOB, Baclofen, Fenibut, and Tolibut. Some of these products are easier to find than 1,4-BD.
>The doses of 1,4-butanediol ingested ranged from 5.4 to 20 g in the patients who died and ranged from 1 to 14 g in the nonfatal cases.
>Patient 1 was a previously healthy 32-year-old man who ingested approximately 200 ml of a dietary supplement called Thunder Nectar for its purported ability to increase libido
>his 29-year-old wife (Patient 2) ingested 110 to 140 ml of the same product.
>They had obtained it from a friend who had purchased it at a sports-nutrition store and told them it was nontoxic.
>The bottle was unlabeled; they received no dosage instructions.
>The woman's last memory was that 15 minutes after drinking the Thunder Nectar, she felt "lightheaded" and sat down in a chair.
>She awoke seven hours later, on the floor with her husband, covered with vomitus and with evidence of fecal incontinence.
>Her husband was dead.
>An autopsy revealed only pulmonary edema.
>There was no evidence of aspiration.
>Patient 3 was a 42-year-old woman who ingested 30 to 60 ml of a dietary supplement called NRG3 to treat insomnia.
>She had a history of depression, for which she was taking sertraline.
>Her boyfriend reported that she was talking with him three hours after taking the NRG3 and was sleeping when he left one hour thereafter
>she was dead when he returned eight hours later. The blood concentrations of sertraline were within the range of postmortem blood
Adverse events, including death, associated with the use of 1,4-butanediol
https://www.ncbi.nlm.nih.gov/pubmed/11150358
>Dosage and levels of GHB/GBL in human tissues.
>Therapeutic Bl 24–88 mg/L
>Drowsiness 25 mg/kg (oral) – 80 mg/L peak plasma
>Amnesia 10 mg/kg (oral)
>Sleep/deep sedation 20–30 mg/kg (oral)
>Recreational 35 mg/kg (oral)
>Anaesthesia >50 mg/L
>Sleep 50 mg/kg (IV) peak blood 170 mg/L
>Sleep 75 mg/kg (oral) peak plasma at 2 h 90 mg/L, plasma at 6 h 9 mg/L
>100 mg/kg (oral) ur peak at 4 h 1100 mg/L
>Galloway et al. (2000) suggest that a potential lethal dose may be between 15 and 50 g (250–750 mg/kg) for a 70 kg person.
