Yes. Over the course of my life, I've been so heavily isolated that the the opportunity for love/romance/sex just never came up. Although, even if I had participated normally and not retreated into permanent hermitism as I did, I extremely doubt it would've made any difference. My inherent wiring disallows the possibility of maintaining human relationships. However, I won't lie and say that I'm not lonely, or sexually frustrated, because I am. I mean, sure, I'd still like to have sex, if possible, but if it isn't with someone I feel a strong connection and emotional bond to, then I don't really see the point. As it stands, I'll in all likelihood suffer the rest of my life with the uniquely profound discomforts which are brought about by lack of intimacy/companionship. Perhaps they don't exist, or at least will never exist for someone like me, but the absence of it is still painfully felt and it all just amounts to one more reason why I'd rather be dead than alive.