Resource Anti-emetics: Reglan vs. Zofran

[not-2-b-the-answer]

I read that nausea and vomiting are also potential side effects of meto, as ironic as that sounds haha. Maybe try Zofran next time? I just worry if it's strong enough to handle an entire 13g N overdose. Everyone's different too, you have to account for that. Some may experience tremors, hallucinations, etc. and others not at all.

I may have to get Zofran … I don't know. If on my next attempt I get sick from the metos, I'm not going to take the N & wait a little longer for Zofran.

 

[Woolfy]

Hey, I'm new here. I haven't seen it mentioned here but, the scopolamine transdermal patch worked very well for me when I had minor surgery a few years back. The pain medicine they gave me after surgery (Including the car ride back home) should of made me have bad motion sickness/nausea and projectile vomit. I had none of that...It may come in pill form, but I had the 1 patch that goes behind your ear. I have only ever tried zofran which seemed to work decent. That's what I'm afraid of it not being able to get passed the nausea/vomiting and or dizziness. Anyways, Hope this helps.

 

[not-2-b-the-answer]

Hey, I'm new here. I haven't seen it mentioned here but, the scopolamine transdermal patch worked very well for me when I had minor surgery a few years back. The pain medicine they gave me after surgery (Including the car ride back home) should of made me have bad motion sickness/nausea and projectile vomit. I had none of that...It may come in pill form, but I had the 1 patch that goes behind your ear. I have only ever tried zofran which seemed to work decent. That's what I'm afraid of it not being able to get passed the nausea/vomiting and or dizziness. Anyways, Hope this helps.

Thanks for the heads up on the patch …. Does anyone else have experiences with them ?

 

[Taylor]

Hey, I'm new here. I haven't seen it mentioned here but, the scopolamine transdermal patch worked very well for me when I had minor surgery a few years back. The pain medicine they gave me after surgery (Including the car ride back home) should of made me have bad motion sickness/nausea and projectile vomit. I had none of that...It may come in pill form, but I had the 1 patch that goes behind your ear. I have only ever tried zofran which seemed to work decent. That's what I'm afraid of it not being able to get passed the nausea/vomiting and or dizziness. Anyways, Hope this helps.

Oh I forgot about those! It's pretty common practice for sailors in the Navy to use those while at sea, to avoid sea sickness.

 

[martha]

You guys are real experts, when it comes to anti-emetics. Thanks for sharing all your research.
Are you absolutely sure, that it has to be meto or zofran?
I mean, Nitschke mentions Dimenhydrinate as an useful alternative and it is so much easier to obtain.

 

[Prénom Surnom]

Some more info re antiemetics

The Oral MAiD Option in Canada Part 1: Medication Protocols (2018) P.4
"Recommended antiemetic regimen includes metoclopramide 20mg plus either ondansetron 8-24mg or dexamethasone 8mg taken orally 1 hour prior to the coma inducing medication."
I think this document has well gathered and concise information on the oral ingestion protocol of each nation.

Guidelines for the Practice of Euthanasia and Physician Assisted Suicide (2012) P.17
(automatic pdf download)
"It is essential that the administration of metoclopramide is started one day (twelve hours) in advance in order to minimise the likelihood of the patient vomiting up the of euthanatic agents. Metoclopramide is the anti-emetic of choice as in addition to its anti-emetic effect, it also speeds up gastrointestinal transit."


Dignified Dying (2015) P.20
The first is Meto...The second choice is domperidon...

Guide to Self-Chosen and Humane Death (2006) P.27-28
Same as Dignified Dying

Bentham has included very helpful attachments. Everyone should read them because they are based on actual research not speculation. The Canadian organization recommends using meto and ondestron together.

 

[Taylor]

Doctor appointment went well today...

 

[Taylor]

So I'm noticing on page 7 of the CAMAP article, it mentions that "Safe compounding of these medications is critical to ensure a stable and palatable product.", and then goes on to describe a mixture they create with the barbiturates. Is this absolutely necessary? Or do people get away with drinking it neat just fine?

 

[Taylor]

The liquid N is already a compounded mixture which contains pretty similar ingredients to what that document lists. That document is just saying that pentobarbital sodium (the active ingredient) has to be mixed. Which it is in the liquid!

Ohhh awesome! Haha thank you for that. :)

 

[Ruffian]

So I'm noticing on page 7 of the CAMAP article, it mentions that "Safe compounding of these medications is critical to ensure a stable and palatable product.", and then goes on to describe a mixture they create with the barbiturates. Is this absolutely necessary? Or do people get away with drinking it neat just fine?

I think this is an important question. I would imagine that recreational drug users wouldn't even wince at the taste of N, but then again, I've never tasted it. I have chewed up various pills of different types of drugs, and the promise of the high definitely got me through the nasty taste just fine. So I imagine a decent anti-emetic, combined with the sincere will to die, would most likely help anyone get over the nasty taste. If you have the good fortune to have obtained N, you might want to practice just chewing on any medication, like Tylenol or something, and then spitting it out. This is not professional, medical advice by any means. But it will get you used to that unique, disgusting taste that only medications seem to have.

My question is, why can they make children's medications that taste good, but not adult versions? Hmmmmm....deep thoughts.

 

[Boochky]

Hi,

What's the suggested dosing for zofran? I haven't seen it or understood.

Thank you!

 

[Sweet emotion]

A mentions that either one can be used, but I've been doing research on my own and reading a lot of reviews and I'm starting to lean more towards Zofran.

From what I've gathered so far, Reglan (metoclopramide) is a dopamine antagonist that combats nausea and vomiting by primarily speeding up the stomach emptying process and I've heard from numerous sources (and from user accounts here as well) that the side effects are terrible. (Hallucinations, tremors and shaking, swelling, numbness, etc.)

Zofran on the other hand, is a serotonin antagonist and is commonly prescribed to treat chemotherapy or post operative nausea/vomiting, and about 95% of reviews I've read say that it is highly effective and works almost immediately, with the only potential side effects being headaches/dizziness and constipation.

I'm gathering you're planning on killing yourself with pills. That is the way I'm going to go. I'd like to give you some tips I was given by a doctor who helps people die with dignity if you would like them. I'll allergic to every kind if anti nausea medication except Zofran so it's my only choice.

A mentions that either one can be used, but I've been doing research on my own and reading a lot of reviews and I'm starting to lean more towards Zofran.

From what I've gathered so far, Reglan (metoclopramide) is a dopamine antagonist that combats nausea and vomiting by primarily speeding up the stomach emptying process and I've heard from numerous sources (and from user accounts here as well) that the side effects are terrible. (Hallucinations, tremors and shaking, swelling, numbness, etc.)

Zofran on the other hand, is a serotonin antagonist and is commonly prescribed to treat chemotherapy or post operative nausea/vomiting, and about 95% of reviews I've read say that it is highly effective and works almost immediately, with the only potential side effects being headaches/dizziness and constipation.

And I've never gotten any sides effects from Zofran

 

[Trainwreck]

I'm gathering you're planning on killing yourself with pills. That is the way I'm going to go. I'd like to give you some tips I was given by a doctor who helps people die with dignity if you would like them. I'll allergic to every kind if anti nausea medication except Zofran so it's my only choice.

And I've never gotten any sides effects from Zofran

My only side effect from zofran is constipation. Otherwise, it's reasonably effective at a 4mg dose. At a higher dose (I believe 8-16 mg is recommended for cbt methods), it could be very effective.

Promethazine works better for me than zofran, but I don't like the sedation I get from it (for routine use, that's obviously a plus for cbt). Ive had no other side effects from it though.

 

[k75]

Because of a medical issue, I've had to take 8mg Zofran multiple times a day for the past 5 years. It usually works extremely well and quickly. I've never had side effects from it.

Sometimes I have to switch to Meto when my condition gets worse. I've never felt it works quite as well as Zofran for me.

My plan has been to take both. My last bottle of Meto is expired, but people assure me that doesn't matter. I still feel better doubling up, since they both work in different ways.

Someone in this thread mentioned Phenergan, but I've only ever been given that in IV form during pancreatitis attacks. It's super amazing though, with the added bonus of sedation. Very strong stuff.

 

[Trainwreck]

Because of a medical issue, I've had to take 8mg Zofran multiple times a day for the past 5 years. It usually works extremely well and quickly. I've never had side effects from it.

Sometimes I have to switch to Meto when my condition gets worse. I've never felt it works quite as well as Zofran for me.

My plan has been to take both. My last bottle of Meto is expired, but people assure me that doesn't matter. I still feel better doubling up, since they both work in different ways.

Someone in this thread mentioned Phenergan, but I've only ever been given that in IV form during pancreatitis attacks. It's super amazing though, with the added bonus of sedation. Very strong stuff.

I had a script for phenergan once, but it was in suppository form.

My doctor told me the US military did a study on how long drugs last, and for the vast majority of them, they were still at 90% and above for effectiveness 20 years after expiration.

 

[k75]

I had a script for phenergan once, but it was in suppository form.

My doctor told me the US military did a study on how long drugs last, and for the vast majority of them, they were still at 90% and above for effectiveness 20 years after expiration.

That's good to know. Similar to what I was told.

Suppositories, huh? Did it make you sleepy? I've always gotten it through IV alongside Dilaudid, and somewhere between the two of those, I'm always knocked the fuck out in like 30 seconds. If only I could just live the rest of my life with those two drugs... LOL

I'm actually contemplating dipping into my Meto stash right now. So freaking nauseous. I figured it would be a good way to test the effectiveness.

 

[Trainwreck]

That's good to know. Similar to what I was told.

Suppositories, huh? Did it make you sleepy? I've always gotten it through IV alongside Dilaudid, and somewhere between the two of those, I'm always knocked the fuck out in like 30 seconds. If only I could just live the rest of my life with those two drugs... LOL

I'm actually contemplating dipping into my Meto stash right now. So freaking nauseous. I figured it would be a good way to test the effectiveness.

The suppositories I had were given to me about 20 years ago, but I don't remember them making me sleepy. Could have been they were a low dose though. Like you, when I've had the combo of phenergan and pain meds in the ER, one or both really sedate me.

Have you ever tried something like the ReliefBand for your nausea? I saw them recommended on a gastroparesis forum. You put it on your wrist, and it puts off a little electrical pulse on a nerve that is supposed to block the nausea feeling. Downside is that they are $100 and up.

 

[k75]

Have you ever tried something like the ReliefBand for your nausea? I saw them recommended on a gastroparesis forum. You put it on your wrist, and it puts off a little electrical pulse on a nerve that is supposed to block the nausea feeling. Downside is that they are $100 and up.

I never have, but now I'm pretty curious about it. I'd never heard of it until very recently, but I just found out there are prescription forms. I'm going to ask my GI doctor about it. Maybe there's a way to get insurance to cover something like it?

Gastroparesis is sometimes a problem for me, and the constant nausea I struggle with is one of the things that brings me here, actually. I'm terrified one day my stomach is just going to decide to stop working. They can't decide what the problem is at this point, but it began with a bile duct blockage. I had to have my gallbladder removed, but there was a lot of damage done. I just basically live in fear of the next pancreatitis attack or gastroparesis episode, and it's really worn me down.

 

[Trainwreck]

That's good to know. Similar to what I was told.

Suppositories, huh? Did it make you sleepy? I've always gotten it through IV alongside Dilaudid, and somewhere between the two of those, I'm always knocked the fuck out in like 30 seconds. If only I could just live the rest of my life with those two drugs... LOL

I'm actually contemplating dipping into my Meto stash right now. So freaking nauseous. I figured it would be a good way to test the effectiveness.

I feel kind of dumb. I have a prescription for promethazine, which I just discovered is...phenergan. And yes, it makes me very sleepy even at a very low dose.

 

[k75]

I feel kind of dumb. I have a prescription for promethazine, which I just discovered is...phenergan. And yes, it makes me very sleepy even at a very low dose.

Don't feel dumb. I've always been given the brand name stuff at the hospital and was never prescribed it to take home, so I totally didn't know those were the same thing!

Yeah, my experience has always been pretty much instant sleep when I've been given it plus painkillers. Which I like. I'd rather be unconscious whenever possible.

 

[Dreamwithinadream]

I currently take both zofran and meto with no major side effects. Zofran works faster but Meto seems to be better at keeping food down. I'll probably just use both.

 

[SprocketFiend]

I currently take both zofran and meto with no major side effects. Zofran works faster but Meto seems to be better at keeping food down. I'll probably just use both.

May I ask how long you have been on Zofran and meto? You mention no major side effects; have you experienced any other, more minor side effects at all?

 

[Dreamwithinadream]

May I ask how long you have been on Zofran and meto? You mention no major side effects; have you experienced any other, more minor side effects at all?

A couple of years. I usually take 8mg zofran a day. Only side effects I've noticed are constipation and headaches. Meto can cause fatigue. I've never taken more than 20mg a day of that. Obviously more people have major side effects with meto than with zofran.

 

[SprocketFiend]

Thank you for the speedy reply, @Dreamwithinadream! I know everyone is different but it does still make me feel better to hear about okay experiences like yours.