Why have some people said meto is too risky to take when doing SN method?

[Tricondyla ledouxi]

Why have some people said meto is too risky to take when doing SN method?

 

[DreamEnd]

It has a low risk of producing close to permanent side effects. Tardive dyskenisia I think which is when you lose control over muscle movements in the facial area. There are safer alternatives to meto.'

 

[Tricondyla ledouxi]

It has a low risk of producing close to permanent side effects. Tardive dyskenisia I think which is when you lose control over muscle movements in the facial area. There are safer alternatives to meto.'

Oh my god. Why isn't that a disclaimer in Stan's guide?! Thanks for telling me.

It has a low risk of producing close to permanent side effects. Tardive dyskenisia I think which is when you lose control over muscle movements in the facial area. There are safer alternatives to meto.'

Also, is meto the only type of antiemetic that does this or do others? And, can other types of antiemetic contain meto? Sorry if the question sounds dumb.

 

[Zegers]

It has a low risk of producing close to permanent side effects.

This is rare and only if you take it for a very long time. For the method you only need to take a few pills.

 

[DreamEnd]

Oh my god. Why isn't that a disclaimer in Stan's guide?! Thanks for telling me.

Also, is meto the only type of antiemetic that does this or do others? And, can other types of antiemetic contain meto? Sorry if the question sounds dumb.

Domperidone appears to have less possibilities of side effects. I'm gonna use that personally but there are others as well

 

[Tricondyla ledouxi]

Domperidone appears to have less possibilities of side effects. I'm gonna use that personally but there are others as well

Okay thanks

 

[punkarmadillo]

Is cyclizine ineffective?

 

[HighHopesGettingLow]

From Rang & Dale's Pharmacology, 9th edition (2020), page 401-403:
Metoclopramide [...] produces a number of unwanted effects including disorders of movement (more common in children and young adults), fatigue, motor restlessness, spasmodic torticollis (involuntary twisting of the neck) and oculogyric crises (involuntary upward eye movements). It stimulates prolactin release [...] causing galactorrhoea and disorders of menstruation.
Domperidone is a similar drug used to treat vomiting [...]. Unlike metoclopramide, it [is] less prone to producing central side effects. However, domperidone is associated with a small increased risk of serious cardiac adverse effects (particularly at higher doses and in older patients), and its use is now restricted.
Both drugs are given orally, have plasma half-lives of 4–5 h and are excreted in the urine.

Clinical use of antiemetic drugs:
– Metoclopramide: vomiting caused by migraine, radiation, gastrointestinal disorders, cytotoxic drugs, prevention of nausea and vomiting in the postoperative period.
– Domperidone is less liable to cause central nervous system side effects [...].
– Cyclizine: motion sickness, vestibular disorders, nausea and vomiting associated with surgery and postoperative narcotic analgesic use.

Is cyclizine ineffective?​

Cinnarizine, cyclizine and promethazine are the most commonly [anti-emetic drugs] employed; they are effective against nausea and vomiting arising from many causes, including motion sickness and the presence of irritants in the stomach. None is very effective against substances that act directly on the CTZ [Chemoreceptor Trigger Zone]. Promethazine is used for morning sickness of pregnancy (on the rare occasions when this is so severe that drug treatment is justified), and has been used by NASA to treat space motion sickness. Drowsiness and sedation, while possibly contributing to their clinical efficacy, are the chief unwanted effects. Betahistine [...] is used to control the nausea and vertigo associated with Menière's disease.

I hope that helps...​