Question about antacid with SN protocol

[Fate]

Hey, if I have an option of either using omeprazole or tagamet (Cimetidine) for SN protocol, which one would be better? I see some people use tagamet, and others use omeprazole so I'm curious about the difference and which one is currently recommended. Thanks :)

 

[athiestjoe]

Neither. Also, they are different types of medications. Tagamet (Cimetidine) is an H2 (histamine-2) receptor antagonist. It blocks the action of histamine on H2 receptors in the stomach lining, which reduces the production of stomach acid. Whereas Prilosec (omeprazole) is a proton pump inhibitor (PPI) and works by inhibiting the proton pumps in the stomach lining, which are responsible for producing acid (leading to a more significant and longer-lasting reduction in stomach acid compared to H2 blockers).

As you may know, PPEH has stopped recommending antacids and acid reducers. They previously included Tagamet in their protocol, however, my distinction of the two is kind of irrelevant now since neither is recommended. That said, many people did use Tagamet in their protocols before it was removed. Keep that in mind, but if you're looking for current recommendations, neither is advised.

Hope you find everything you are looking for and get peace & serenity.

 

[Fate]

Neither. Also, they are different types of medications. Tagamet (Cimetidine) is an H2 (histamine-2) receptor antagonist. It blocks the action of histamine on H2 receptors in the stomach lining, which reduces the production of stomach acid. Whereas Prilosec (omeprazole) is a proton pump inhibitor (PPI) abd works by inhibiting the proton pumps in the stomach lining, which are responsible for producing acid (leading to a more significant and longer-lasting reduction in stomach acid compared to H2 blockers).

As you may know, PPEH has stopped recommending antacids and acid reducers. They previously included Tagamet in their protocol, although I don't believe Prilosec was ever part of it. However, that distinction is kind of irrelevant now since neither is recommended. That said, many people did use Tagamet in their protocols before it was removed. Keep that in mind, but if you're looking for current recommendations, neither is advised.

Hope you find everything you are looking for and get peace & serenity.

Thank you, is there a reason why tagamet isn't recommended anymore? Is it because they can't tell if it's beneficial to the protocol or actually a negative?

 

[athiestjoe]

Is it because they can't tell if it's beneficial to the protocol or actually a negative?

The former.

Thank you, is there a reason why tagamet isn't recommended anymore?

Honestly, the benefits just can't be nailed down. If you check this site for antacid, you'll find a ton of debates about whether it's good or bad, but in the end, it's all pretty much just educated guessing.

The PPEH says that the benefits or potential of an antacid "cannot be established." Plus, Vizzy, who cites Dr. PN from the PPH, mentions that some nitric oxide production from the reaction between stomach acid and nitrite might help lower blood pressure and might speed up unconsciousness.

Basically raising the pH of the stomach (lowering the acidity) decreases the SN converting into Nitric oxide which is a vasodilator that will drop your blood pressure drastically resulting in unconsciousness. This is the main and fastest mechanism that SN knocks you out and antacids can slow this process resulting in you staying conscious longer. Most people think SN knocks you out by lowering oxygen levels in your tissues and yes that would eventually lead to unconsciousness, but the vasodilator effect is much quicker and is why people who take SN can collapse at any time without warning so it's best to be laying down or sitting after you take it.

Here was Dr. PN's direct words as to why it was taken out from the protocol though:

It sounds promising in theory, but when it comes to measurable differences—like whether it shortens unconsciousness by one, two, three, or even five minutes or any at all—it's all uncertain. That's why the protocol states that its benefits or potentiation cannot be established.

That said, I don't believe using it would harm the protocol if someone chooses to do so.

I hope this helps and doesn't just add more confusion around it. With whatever you decide, I hope you find everything you are looking for.

 

[cowboypants]

Omeprazole is the better option out of the two.

There has been atleast two studies which has compared them. But I don't think it matters much for a single use. I would still pickup Omeprazole tho.

As you may know, PPEH has stopped recommending antacids and acid reducers. They previously included Tagamet in their protocol, however, my distinction of the two is kind of irrelevant now since neither is recommended. That said, many people did use Tagamet in their protocols before it was removed. Keep that in mind, but if you're looking for current recommendations, neither is advised.

I'm not fully sold out on removing acid reducers. As acid reducers will decrease ones acid reflux and maybe even help reducing vomiting. While there's little side effect from taking them.