Method Opioids?

[ecolofienjoyer]

As far as I know Its the most painless way to go. ignoring acquisition, most of them are very easy to od on and mostly just end with you so chilled out that your lungs forget to breathe. idk

 

[coolgal82]

tbf with them theres still a risk of not dying and like getting some permanent bad effects from survivng, plus i don't think its necessarily as peaceful as people claim, i've had minor ods on them and there was alot of nausea (though maybe when you get into higher levels of od the nausea is overcome idk). i did od to the point of passing out twice and the first time i woke up and had spilt food everywhere, and i think the 2nd time i slept on my arm funny and woke up with weakness in that arm for like 2 weeks so you could theoretically end up with more permanent nerve damage
plus opioids are easily reversed with naloxone if you're found in time so if you wanna use them as a method, make sure you won't be found
theyre definitely not like a bad option and theyre not that hard to get if you know where to look but just be prepared fot eh nausea and possibly if you start panicking when you like start having respiratory depresson which i think can happen, just like do as much research as you can into possible side effects and try work out ways to avoid them

 

[ecolofienjoyer]

tbf with them theres still a risk of not dying and like getting some permanent bad effects from survivng, plus i don't think its necessarily as peaceful as people claim, i've had minor ods on them and there was alot of nausea (though maybe when you get into higher levels of od the nausea is overcome idk). i did od to the point of passing out twice and the first time i woke up and had spilt food everywhere, and i think the 2nd time i slept on my arm funny and woke up with weakness in that arm for like 2 weeks so you could theoretically end up with more permanent nerve damage
plus opioids are easily reversed with naloxone if you're found in time so if you wanna use them as a method, make sure you won't be found

Thanks. to be clear, the 2 things are,
when attempting: ~make sure you have a high enough dosage
~make sure no one will find you

 

[TheEmptyVoid]

tbf with them theres still a risk of not dying and like getting some permanent bad effects from survivng, plus i don't think its necessarily as peaceful as people claim, i've had minor ods on them and there was alot of nausea (though maybe when you get into higher levels of od the nausea is overcome idk). i did od to the point of passing out twice and the first time i woke up and had spilt food everywhere, and i think the 2nd time i slept on my arm funny and woke up with weakness in that arm for like 2 weeks so you could theoretically end up with more permanent nerve damage
plus opioids are easily reversed with naloxone if you're found in time so if you wanna use them as a method, make sure you won't be found
theyre definitely not like a bad option and theyre not that hard to get if you know where to look but just be prepared fot eh nausea and possibly if you start panicking when you like start having respiratory depresson which i think can happen, just like do as much research as you can into possible side effects and try work out ways to avoid them

I mean, opioids can be used to make the feeling of suffocation (the feeling of urge to breathe) be absent and gone (the feeling of needing to breathe (feeling of suffocation) is caused by carbon dioxide build up from your metabolism being NOT able to exit your lungs from the blood and lack of oxygen doesn't cause the urge to breathe), and then after swallowing the opioids in a good dose, I can just simply use a plastic bag and a cord to tie it in place and seal it (you know where I will put the plastic bag on, I probably can't say it here), but I don't know if my unconscious convulsions *might* make me rip the bag.

 

[OzymandiAsh]

Thanks. to be clear, the 2 things are,
when attempting: ~make sure you have a high enough dosage
~make sure no one will find you

Ideally you want to get an anti emetic like metoclopramide as well, and take maybe 40mg 40 minutes before (like the SN protocol), so you don't just vomit up the pills or whatever.
Snorting can increase bioavailability also.
Lastly, you want to combine with alcohol to potentiate the respiratory depression.

 

[coolgal82]

Ideally you want to get an anti emetic like metoclopramide as well, and take maybe 40mg 40 minutes before (like the SN protocol), so you don't just vomit up the pills or whatever.
Snorting can increase bioavailability also.
Lastly, you want to combine with alcohol to potentiate the respiratory depression.

anti emetics are good, though iirc snorting can for some substances shorten the duration of action so make sure do research into different roas for your chosen opioid (also don't forget boofing and injecting could also be an option), plus benzos could also theoretically potentiate the sedation and lessen any anxiety you might get, as well as partially potentiating respiratory depression. pregabalin is another potential good one for a similar use to benzos, i've mixed benzos and pregabalin a few times and even with low amounts of each ive fallen asleep involuntarily alot. benzos would also probably be better than alcohol as alcohol increases nausea and makes it more likely you might vomit it up

I mean, opioids can be used to make the feeling of suffocation (the feeling of urge to breathe) be absent and gone (the feeling of needing to breathe (feeling of suffocation) is caused by carbon dioxide build up from your metabolism being NOT able to exit your lungs from the blood and lack of oxygen doesn't cause the urge to breathe), and then after swallowing the opioids in a good dose, I can just simply use a plastic bag and a cord to tie it in place and seal it (you know where I will put the plastic bag on, I probably can't say it here), but I don't know if my unconscious convulsions *might* make me rip the bag.

with respiratory depression iirc carbon dioxide still builds up, it's just that you can't like breathe it out or breathe new oxygen in
from wikipedia: "Carbon dioxide may accumulate in any condition that causes hypoventilation, a reduction of alveolar ventilation (the clearance of air from the small sacs of the lung where gas exchange takes place) as well as resulting from inhalation of CO2." (hypoventilation is another name for respiratory depression)
complete respiratory arrest also results in the same thing to my knowledge

 

[carfemtanyl]

as far as I know, opioid OD kill you by inhibiting the part of the brain that does the involuntary breathing (e.g. when you hold your breath for too long, you will eventually breath again) since that region has a lot of mu-opioid receptors

 

[OzymandiAsh]

anti emetics are good, though iirc snorting can for some substances shorten the duration of action so make sure do research into different roas for your chosen opioid (also don't forget boofing and injecting could also be an option), plus benzos could also theoretically potentiate the sedation and lessen any anxiety you might get, as well as partially potentiating respiratory depression. pregabalin is another potential good one for a similar use to benzos, i've mixed benzos and pregabalin a few times and even with low amounts of each ive fallen asleep involuntarily alot. benzos would also probably be better than alcohol as alcohol increases nausea and makes it more likely you might vomit it up

Wouldn't benzos also increase nausea? I have a few benzo pills I'm going to throw into the mix, but not many. I could also get more/some pregabs, but I was planning on attempting a 1500mg codeine + alcohol OD tomorrow (snorting as much of the codeine as possible and taking the rest orally).

 

[coolgal82]

Wouldn't benzos also increase nausea? I have a few benzo pills I'm going to throw into the mix, but not many. I could also get more/some pregabs, but I was planning on attempting a 1500mg codeine + alcohol OD tomorrow (snorting as much of the codeine as possible and taking the rest orally).

benzos don't really have any effect on nausea, also snorting codeine is a horrible idea cus codeine has to be metabolised into morphine in the liver so snorting it would bypass that
also codeine itself is very weak im not sure it would be effective in an od even at that dosage, though you could try using dxm or grapefruit juice to potentiate it
also just remembered codeine has an upper limit to how much you can metabolise in one go, so anything above like around 400mg total isnt gonna do anything (well it doesnt increase some effects but can increase some side effects like itchiness and nausea so it's a gamble on whether it would kill you or not), you need a better opioid

 

[ecolofienjoyer]

Ideally you want to get an anti emetic like metoclopramide as well, and take maybe 40mg 40 minutes before (like the SN protocol), so you don't just vomit up the pills or whatever.
Snorting can increase bioavailability also.
Lastly, you want to combine with alcohol to potentiate the respiratory depression.

arent some opiods injectable?

 

[OzymandiAsh]

benzos don't really have any effect on nausea, also snorting codeine is a horrible idea cus codeine has to be metabolised into morphine in the liver so snorting it would bypass that
also codeine itself is very weak im not sure it would be effective in an od even at that dosage, though you could try using dxm or grapefruit juice to potentiate it
also just remembered codeine has an upper limit to how much you can metabolise in one go, so anything above like around 400mg total isnt gonna do anything (well it doesnt increase some effects but can increase some side effects like itchiness and nausea so it's a gamble on whether it would kill you or not), you need a better opioid

Huh, you are correct about the snorting. That's what I get for doing research on Grok as that's where I got the idea. Thanks for making me double check that.

I know codeine is weak but it's what I have at the moment, I figure it's worth a shot at least.

arent some opiods injectable?

Of course, but not codeine pills.

 

[coolgal82]

Huh, you are correct about the snorting. That's what I get for doing research on Grok as that's where I got the idea. Thanks for making me double check that.

I know codeine is weak but it's what I have at the moment, I figure it's worth a shot at least.

Of course, but not codeine pills.

1. why would you trust an ai for researching this stuff
2. of all ai, why fuckijg grok?
also it isnt really worth a shot, its a higher chance you would survive and have to live with like the consequences of it (physical or mental or social or whatever) for the redt of your life (however long thatd be), just get a stronger opioid. it's not worth it to try. it's equally as silly as trying a paracetamol od or an ssri od or anything like that

 

[OzymandiAsh]

1. why would you trust an ai for researching this stuff
2. of all ai, why fuckijg grok?
also it isnt really worth a shot, its a higher chance you would survive and have to live with like the consequences of it (physical or mental or social or whatever) for the redt of your life (however long thatd be), just get a stronger opioid. it's not worth it to try. it's equally as silly as trying a paracetamol od or an ssri od or anything like that

Grok isn't nearly as censored as other AIs.

Also, I was looking further into it and it does seem there is some basis for arguing that snorting might increase lethality.

Spoiler: snorting

"can snorting codeine be fatal"
[TLDR: Yes, potentially even more fatal than oral consumption]

"but codeine is metabolised in the liver. so snorting it would lead to less morphine and lower risk of respiratory depression"

No, that's not accurate—snorting codeine does bypass the liver's first-pass metabolism (which occurs after oral ingestion via the gastrointestinal tract and portal vein), but this actually leads to higher overall bioavailability of codeine in the bloodstream compared to oral administration. Codeine is a prodrug with relatively weak intrinsic opioid activity (about 1/10th the potency of morphine), and its primary effects come from hepatic metabolism via the CYP2D6 enzyme to its active metabolite, morphine (typically 5-10% of the dose). However, the pharmacokinetics differ by route in ways that don't reduce risk:

Impact on Metabolism and Morphine Conversion

• Oral route: Codeine undergoes partial first-pass metabolism in the liver, where some is converted to morphine before entering systemic circulation. Oral bioavailability is around 40-60%, meaning some codeine is lost to other metabolic pathways (e.g., to norcodeine or glucuronides) during this pass. This results in a slower rise in blood levels, with peak concentrations after about 1 hour.
• Intranasal route (snorting): Absorption occurs directly through the nasal mucosa into systemic circulation, bypassing first-pass and increasing codeine's bioavailability to nearly 100%. This means more unchanged codeine reaches the bloodstream quickly (peak in 10-20 minutes, similar to other intranasal opioids like heroin or hydromorphone). Once in circulation, the higher codeine levels are still metabolized by the liver over time via CYP2D6 to morphine. Because less codeine is "lost" upfront to non-morphine pathways, the total morphine produced can be comparable or even higher overall, though with faster kinetics due to the rapid codeine spike.

Codeine's oral-to-parenteral (e.g., injection or snorting equivalent) potency ratio is high (around 60%), unlike stronger opioids like morphine (where oral is much weaker due to extensive first-pass). This is because codeine experiences less overall first-pass inactivation, but bypassing it still amplifies peak exposure.

Risk of Respiratory Depression

Respiratory depression (slowed or stopped breathing) is primarily driven by morphine's action on mu-opioid receptors in the brainstem, though codeine contributes weakly. Snorting doesn't lower this risk—it increases it due to:

• Faster onset and higher peaks: Rapid absorption leads to quicker, more intense opioid effects, including sedation and breathing suppression, raising the chance of acute overdose before the body can adjust.
• Dose equivalence issues: People often snort the same amount as an oral dose, but with higher bioavailability, this effectively delivers more drug systemically, potentially leading to excessive morphine buildup.
• Genetic factors: In ultra-rapid CYP2D6 metabolizers (5-10% of Caucasians), conversion to morphine is faster and higher regardless of route, amplifying risks. Poor metabolizers get little effect from either route.
• Compounding factors: Mixing with depressants (e.g., alcohol, benzodiazepines) or having conditions like sleep apnea heightens respiratory risks more with rapid routes like snorting.

Fatal doses of codeine are typically 500-1000 mg, but tolerance, mixtures, and route affect this. Snorting crushed tablets also introduces risks from fillers/irritants (e.g., acetaminophen in combos like Tylenol with codeine), which can cause nasal/lung damage or toxicity.


In summary, while snorting avoids initial first-pass conversion, it results in higher and faster codeine exposure, which doesn't reduce (and may increase) total morphine levels or the risk of respiratory depression compared to oral use at equivalent doses.

Edit: Just double checked this with ChatGPT, which disagrees and thinks oral consumption leads to more morphine and is therefore more likely to be fatal. So yeah Grok's highly technical answer above is probably just BS and it's my bad for using it, sorry. Surprisingly I was able to get some direct answers from ChatGPT about this, which is usually extremely censored.


I might be able to get oxycodone. Do you think I could combine the two, or would I want to stick to just the oxycodone?

 

[coolgal82]

Grok isn't nearly as censored as other AIs.

Also, I was looking further into it and it does seem there is some basis for arguing that snorting might increase lethality.

Spoiler: snorting

"can snorting codeine be fatal"
[TLDR: Yes, potentially even more fatal than oral consumption]

"but codeine is metabolised in the liver. so snorting it would lead to less morphine and lower risk of respiratory depression"

No, that's not accurate—snorting codeine does bypass the liver's first-pass metabolism (which occurs after oral ingestion via the gastrointestinal tract and portal vein), but this actually leads to higher overall bioavailability of codeine in the bloodstream compared to oral administration. Codeine is a prodrug with relatively weak intrinsic opioid activity (about 1/10th the potency of morphine), and its primary effects come from hepatic metabolism via the CYP2D6 enzyme to its active metabolite, morphine (typically 5-10% of the dose). However, the pharmacokinetics differ by route in ways that don't reduce risk:

Impact on Metabolism and Morphine Conversion

• Oral route: Codeine undergoes partial first-pass metabolism in the liver, where some is converted to morphine before entering systemic circulation. Oral bioavailability is around 40-60%, meaning some codeine is lost to other metabolic pathways (e.g., to norcodeine or glucuronides) during this pass. This results in a slower rise in blood levels, with peak concentrations after about 1 hour.
• Intranasal route (snorting): Absorption occurs directly through the nasal mucosa into systemic circulation, bypassing first-pass and increasing codeine's bioavailability to nearly 100%. This means more unchanged codeine reaches the bloodstream quickly (peak in 10-20 minutes, similar to other intranasal opioids like heroin or hydromorphone). Once in circulation, the higher codeine levels are still metabolized by the liver over time via CYP2D6 to morphine. Because less codeine is "lost" upfront to non-morphine pathways, the total morphine produced can be comparable or even higher overall, though with faster kinetics due to the rapid codeine spike.

Codeine's oral-to-parenteral (e.g., injection or snorting equivalent) potency ratio is high (around 60%), unlike stronger opioids like morphine (where oral is much weaker due to extensive first-pass). This is because codeine experiences less overall first-pass inactivation, but bypassing it still amplifies peak exposure.

Risk of Respiratory Depression

Respiratory depression (slowed or stopped breathing) is primarily driven by morphine's action on mu-opioid receptors in the brainstem, though codeine contributes weakly. Snorting doesn't lower this risk—it increases it due to:

• Faster onset and higher peaks: Rapid absorption leads to quicker, more intense opioid effects, including sedation and breathing suppression, raising the chance of acute overdose before the body can adjust.
• Dose equivalence issues: People often snort the same amount as an oral dose, but with higher bioavailability, this effectively delivers more drug systemically, potentially leading to excessive morphine buildup.
• Genetic factors: In ultra-rapid CYP2D6 metabolizers (5-10% of Caucasians), conversion to morphine is faster and higher regardless of route, amplifying risks. Poor metabolizers get little effect from either route.
• Compounding factors: Mixing with depressants (e.g., alcohol, benzodiazepines) or having conditions like sleep apnea heightens respiratory risks more with rapid routes like snorting.

Fatal doses of codeine are typically 500-1000 mg, but tolerance, mixtures, and route affect this. Snorting crushed tablets also introduces risks from fillers/irritants (e.g., acetaminophen in combos like Tylenol with codeine), which can cause nasal/lung damage or toxicity.


In summary, while snorting avoids initial first-pass conversion, it results in higher and faster codeine exposure, which doesn't reduce (and may increase) total morphine levels or the risk of respiratory depression compared to oral use at equivalent doses.

grok is garbage, plus it's biased as hell because it's creator is a manchild who cant handle opposing views. all ai is garbage tbh and constantly wrong about things but grok is probably the worst.
also no all of that just wrong please do not trust ai. try searching about snorting codiene in drug related subreddits/comunities if you don't believe me, there are atleast a few people in those that know what theyre talking about. the only codiene you'd absorb is the stuff that drips down from your nose to your stomach. it's about the same idea as snorting benzos (which have 0 nasal bioavailability)
even if some codiene still gets metabolised, its equal to or less than the amount you'd get from taking it orally, plus when it does inevitably fail to kill you (because it will lol), you'll end up with other serious health issues that you now have to suffer through.

Opioids - Is snorting codeine worth it?

is snorting codeine phosphate 30mg worth it? how much is a safe/dangerous amount, and does it actually get you higher faster and with a lower dose? i've heard different things

www.bluelight.org

codeine insuffilated

Many folks on here speak about the dangers of insuffilating (snorting) codeine. However others claim to have done it for years. On wikipedia's page for codeine under routes of administration it lists: oral, intra-nasally, intra-rectally, SC, IM What is the truth about codeine being...

www.bluelight.org

2 bluelight threads for examples of why it doesnt work and why you shouldnt
even if you still wanted to, the pill binders snd fillers would clog up your nose before you got to anywhere close to a significsnt amount

 

[OzymandiAsh]

grok is garbage, plus it's biased as hell because it's creator is a manchild who cant handle opposing views. all ai is garbage tbh and constantly wrong about things but grok is probably the worst.
also no all of that just wrong please do not trust ai. try searching about snorting codiene in drug related subreddits/comunities if you don't believe me, there are atleast a few people in those that know what theyre talking about. the only codiene you'd absorb is the stuff that drips down from your nose to your stomach. it's about the same idea as snorting benzos (which have 0 nasal bioavailability)
even if some codiene still gets metabolised, its equal to or less than the amount you'd get from taking it orally, plus when it does inevitably fail to kill you (because it will lol), you'll end up with other serious health issues that you now have to suffer through.

I edited my post BTW ^

I know Grok sucks, and I hate Elon Musk, but in my desperation for info, I use it to look up technical/practical suicide related stuff sometimes because ChatGPT will refuse to talk about anything like that most of the time. I'll be more careful in the future though.

 

[coolgal82]

Grok isn't nearly as censored as other AIs.

Also, I was looking further into it and it does seem there is some basis for arguing that snorting might increase lethality.

Spoiler: snorting

"can snorting codeine be fatal"
[TLDR: Yes, potentially even more fatal than oral consumption]

"but codeine is metabolised in the liver. so snorting it would lead to less morphine and lower risk of respiratory depression"

No, that's not accurate—snorting codeine does bypass the liver's first-pass metabolism (which occurs after oral ingestion via the gastrointestinal tract and portal vein), but this actually leads to higher overall bioavailability of codeine in the bloodstream compared to oral administration. Codeine is a prodrug with relatively weak intrinsic opioid activity (about 1/10th the potency of morphine), and its primary effects come from hepatic metabolism via the CYP2D6 enzyme to its active metabolite, morphine (typically 5-10% of the dose). However, the pharmacokinetics differ by route in ways that don't reduce risk:

Impact on Metabolism and Morphine Conversion

• Oral route: Codeine undergoes partial first-pass metabolism in the liver, where some is converted to morphine before entering systemic circulation. Oral bioavailability is around 40-60%, meaning some codeine is lost to other metabolic pathways (e.g., to norcodeine or glucuronides) during this pass. This results in a slower rise in blood levels, with peak concentrations after about 1 hour.
• Intranasal route (snorting): Absorption occurs directly through the nasal mucosa into systemic circulation, bypassing first-pass and increasing codeine's bioavailability to nearly 100%. This means more unchanged codeine reaches the bloodstream quickly (peak in 10-20 minutes, similar to other intranasal opioids like heroin or hydromorphone). Once in circulation, the higher codeine levels are still metabolized by the liver over time via CYP2D6 to morphine. Because less codeine is "lost" upfront to non-morphine pathways, the total morphine produced can be comparable or even higher overall, though with faster kinetics due to the rapid codeine spike.

Codeine's oral-to-parenteral (e.g., injection or snorting equivalent) potency ratio is high (around 60%), unlike stronger opioids like morphine (where oral is much weaker due to extensive first-pass). This is because codeine experiences less overall first-pass inactivation, but bypassing it still amplifies peak exposure.

Risk of Respiratory Depression

Respiratory depression (slowed or stopped breathing) is primarily driven by morphine's action on mu-opioid receptors in the brainstem, though codeine contributes weakly. Snorting doesn't lower this risk—it increases it due to:

• Faster onset and higher peaks: Rapid absorption leads to quicker, more intense opioid effects, including sedation and breathing suppression, raising the chance of acute overdose before the body can adjust.
• Dose equivalence issues: People often snort the same amount as an oral dose, but with higher bioavailability, this effectively delivers more drug systemically, potentially leading to excessive morphine buildup.
• Genetic factors: In ultra-rapid CYP2D6 metabolizers (5-10% of Caucasians), conversion to morphine is faster and higher regardless of route, amplifying risks. Poor metabolizers get little effect from either route.
• Compounding factors: Mixing with depressants (e.g., alcohol, benzodiazepines) or having conditions like sleep apnea heightens respiratory risks more with rapid routes like snorting.

Fatal doses of codeine are typically 500-1000 mg, but tolerance, mixtures, and route affect this. Snorting crushed tablets also introduces risks from fillers/irritants (e.g., acetaminophen in combos like Tylenol with codeine), which can cause nasal/lung damage or toxicity.


In summary, while snorting avoids initial first-pass conversion, it results in higher and faster codeine exposure, which doesn't reduce (and may increase) total morphine levels or the risk of respiratory depression compared to oral use at equivalent doses.

Edit: Just double checked this with ChatGPT, which disagrees and thinks oral consumption leads to more morphine and is therefore more likely to be fatal. So yeah Grok's highly technical answer above is probably just BS and it's my bad for using it, sorry. Surprisingly I was able to get some direct answers from ChatGPT about this, which is usually extremely censored.


I might be able to get oxycodone. Do you think I could combine the two, or would I want to stick to just the oxycodone?

oxycodone is much more likely to be lethal (it's like i think third behind heroin and fent for leading causes of opioid od) , though i'd suggest not mixing it with codiene cus both are iirc metabolised mainly by the same enzyme and i'm not sure if that would lead to higher oxycodone presence in your body and increased effects, or lower metabolites which if some of the metabolites are also active in higher amounts could lead to a lower effect. i don't know enough about what % of its metsbolites are inactive and which are active though so i'd reccomend just that on its own, it's just another risk that could potentially hamper the effect
also if you do take oxy, do it orally because it has a higher oral bioavailability than nasal by like a 2x increase i think
also, keep in mind grapefruit juice can potentiate opioids, so can a small amount of dextromethorphan which can be bought as cough medicine in many shops and even online, i've heard black peper also can potentiate them but i don't fully know about that

 

[Arvayn]

Just incase people don't know, there is a pretty useful and informative thread on this exact subject:

Opioid Megathread & Overview

Preamble I wanted to write something similar to Stan's guide to SN but I hesitate to call this a guide because I can't in good conscience make a guide for something so unreliable in terms of access, lethality, and risk of permanent injury. I.e., traumatic brain injury from hypoxia. SN is a far...

sanctioned-suicide.net

 

[ecolofienjoyer]

Just incase people don't know, there is a pretty useful and informative thread on this exact subject:

Opioid Megathread & Overview

Preamble I wanted to write something similar to Stan's guide to SN but I hesitate to call this a guide because I can't in good conscience make a guide for something so unreliable in terms of access, lethality, and risk of permanent injury. I.e., traumatic brain injury from hypoxia. SN is a far...

sanctioned-suicide.net

thank youuu <3