Is N effective when administered to young healthy people?

[ddd1234]

I worry that it works only with old and sick

 

[intr0verse]

Yes, it will be effective regardless of your age and/or illness. I would say it works on anyone owing a brain (no pun intended).

 

[healthrecovery]

I heard anti psychotics can reduce effectiveness of N

 

[Smart No More]

I heard anti psychotics can reduce effectiveness of N

This is true to an extent. It is said to prolong the coma phase.

 

[healthrecovery]

This is true to an extent. It is said to prolong the coma phase.

This worries me to no end..don't want it to take alot of time

 

[intr0verse]

This is just my opinion but i don't think in practice benzos, antipsychotics or alcohol can impact an overdose of N. There is no evidence, like a causality relation betwewn the use of any of these drugs and a long comatose state experienced by (a very low percentage of) people taking N. All there is, is correlation: they have looked through the medical and drug use history of those who experienced a long comatose state and assumed some drugs might be to blame.
In the antipsychotics and chronic heavy use of alcohol, the idea is that they activate the CYP450 family of enzimes responsible with breaking down the N and hence more N is broken down instead of reaching the systemic circulation and the brain; even if that was the case, i think even 6g of N is way too much for the liver to break down in a single shot and then how would a liver f**ed up by alcohol can still metabolize large amounts of drugs is beyond my understanding. I'm pretty sure paracetamol still works on alcoholic people.
Regarding cross-tolerance with benzos, if you've been using benzos for a number of years and they still work on you, then chances are (very high) that N will work too.
I would conclude that in one case in Washington, the cause for the long comatose state experienced by the patient turned out to be the laxative they've used to sweeten the drink so be careful what you're using :d

 

[sanguineblade]

This is just my opinion but i don't think in practice benzos, antipsychotics or alcohol can impact an overdose of N. There is no evidence, like a causality relation betwewn the use of any of these drugs and a long comatose state experienced by (a very low percentage of) people taking N. All there is, is correlation: they have looked through the medical and drug use history of those who experienced a long comatose state and assumed some drugs might be to blame.
In the antipsychotics and chronic heavy use of alcohol, the idea is that they activate the CYP450 family of enzimes responsible with breaking down the N and hence more N is broken down instead of reaching the systemic circulation and the brain; even if that was the case, i think even 6g of N is way too much for the liver to break down in a single shot and then how would a liver f**ed up by alcohol can still metabolize large amounts of drugs is beyond my understanding. I'm pretty sure paracetamol still works on alcoholic people.
Regarding cross-tolerance with benzos, if you've been using benzos for a number of years and they still work on you, then chances are (very high) that N will work too.
I would conclude that in one case in Washington, the cause for the long comatose state experienced by the patient turned out to be the laxative they've used to sweeten the drink so be careful what you're using :d

is that true about laxative? lol, so better not use anything to sweeten it

 

[PerpetualPain]

This is just my opinion but i don't think in practice benzos, antipsychotics or alcohol can impact an overdose of N. There is no evidence, like a causality relation betwewn the use of any of these drugs and a long comatose state experienced by (a very low percentage of) people taking N. All there is, is correlation: they have looked through the medical and drug use history of those who experienced a long comatose state and assumed some drugs might be to blame.
In the antipsychotics and chronic heavy use of alcohol, the idea is that they activate the CYP450 family of enzimes responsible with breaking down the N and hence more N is broken down instead of reaching the systemic circulation and the brain; even if that was the case, i think even 6g of N is way too much for the liver to break down in a single shot and then how would a liver f**ed up by alcohol can still metabolize large amounts of drugs is beyond my understanding. I'm pretty sure paracetamol still works on alcoholic people.
Regarding cross-tolerance with benzos, if you've been using benzos for a number of years and they still work on you, then chances are (very high) that N will work too.
I would conclude that in one case in Washington, the cause for the long comatose state experienced by the patient turned out to be the laxative they've used to sweeten the drink so be careful what you're using :d

I am a very unique case. I have a rare condition called Post Finasteride Syndrome. It has affected my GABAa receptors to a degree because I no longer produce the neurosteroids that interact with them. Benzo's worked for me for a very brief period but now are completely ineffective. I also cannot get drunk from alcohol anymore which also plays on GABA. My worry with N is that due to my GABA dysfunction that it might not work effectively. However this is still my preferred method as I am too much of a coward for any other method. I'm just worried I could be one of the cases that would be stuck in an extended coma. Will you still CTB if this is the case? Or can you be saved all the way up until you are actually dead?

 

[sfabians]

After drinking 100ml, what's the longest it will take to complete ctb?

 

[intr0verse]

I am a very unique case. I have a rare condition called Post Finasteride Syndrome. It has affected my GABAa receptors to a degree because I no longer produce the neurosteroids that interact with them. Benzo's worked for me for a very brief period but now are completely ineffective. I also cannot get drunk from alcohol anymore which also plays on GABA. My worry with N is that due to my GABA dysfunction that it might not work effectively. However this is still my preferred method as I am too much of a coward for any other method. I'm just worried I could be one of the cases that would be stuck in an extended coma. Will you still CTB if this is the case? Or can you be saved all the way up until you are actually dead?

I am not an expert, but my understanding is that the opposite should be true: long-term treatment with finasteride should decrease the levels of DHT; by doing so, it also decrease the levels of neurosteroids derived from DHT, your particular interest is 3-alpha-androstaneidol which activate the GABA-A receptor. So, if there is less neurosteroid to activate the receptor, on the long run, the body should compensate by up-regulating the number of receptors.
This is a non-expert, simplistic view so maybe that's not the whole story.
Anyway, based on what you report about the effects of benzos and alcohol, i'm not sure any method that involves using sedatives would work in your case. As there is always a "but", when we're talking about cross-tolerance and/or messed up receptors, we compare our reaction to a therapeutic dose of a sedative with an overdose. Also, barbiturates have this property that in high dose, they activate the GABA receptor by themselves even in the absence of the neurotransmitter GABA.
I can't really advise you, the decision to try N or not, should be yours and yours only. I am really sorry for you having to deal with this state of uncertainty on top of your already existing problems.

 

[PerpetualPain]

I am not an expert, but my understanding is that the opposite should be true: long-term treatment with finasteride should decrease the levels of DHT; by doing so, it also decrease the levels of neurosteroids derived from DHT, your particular interest is 3-alpha-androstaneidol which activate the GABA-A receptor. So, if there is less neurosteroid to activate the receptor, on the long run, the body should compensate by up-regulating the number of receptors.
This is a non-expert, simplistic view so maybe that's not the whole story.
Anyway, based on what you report about the effects of benzos and alcohol, i'm not sure any method that involves using sedatives would work in your case. As there is always a "but", when we're talking about cross-tolerance and/or messed up receptors, we compare our reaction to a therapeutic dose of a sedative with an overdose. Also, barbiturates have this property that in high dose, they activate the GABA receptor by themselves even in the absence of the neurotransmitter GABA.
I can't really advise you, the decision to try N or not, should be yours and yours only. I am really sorry for you having to deal with this state of uncertainty on top of your already existing problems.

And here is yet another reason why a severe case of PFS is possibly the worst disease on the planet. Can't even be sure N will work because brain has been so messed up by an FDA approved poison. I am living in a sci fi horror movie every single day because I simply didnt want to lose my hair.

I am a very unique case. I have a rare condition called Post Finasteride Syndrome. It has affected my GABAa receptors to a degree because I no longer produce the neurosteroids that interact with them. Benzo's worked for me for a very brief period but now are completely ineffective. I also cannot get drunk from alcohol anymore which also plays on GABA. My worry with N is that due to my GABA dysfunction that it might not work effectively. However this is still my preferred method as I am too much of a coward for any other method. I'm just worried I could be one of the cases that would be stuck in an extended coma. Will you still CTB if this is the case? Or can you be saved all the way up until you are actually dead?

@Dystopia I mentioned this in another thread and somebody said you may know. Are you able to weigh in?

 

[FromGermany]

Every method works better with very old or terminally ill people. Look at the workshops of the Nitschke sect. It looks like, the majority are 70+ old people. No surprise, that the exit bag method is working well.

With that group of people.

That does not mean, all methods will not work with younger, but if one is young and healthy, a research for the rare cases and how to avoid complications and SI is a must. Even I, in the middle of the 50s and not terminally ill, would drink two bottles the Hulk Hogan way but prepare everything, that I will not be found for at least 24 hours.