Discussion Drugs.com rates Zofran (8/10) over Metoclopramide (4/10) for nausea

[spanishguy22]

I was wondering about this. Drugs.com reviews rates zofran (with 150 reviews) one of the most effective nausea drugs while meto (90 reviews) is significantly more negatively rated for that purpose. Thoughts?



https://www.drugs.com/condition/nausea-vomiting.html
I may get Zofran now actually, may be more effective.

EDIT:
Um I may have jumped the gun, seems like is zofran is effective is when used for cancer but they work differently so meto is more for a suicidal purpose...

"Metoclopramide is used by Dignitas and i think it's the recommened antiemetic in OD, the second one being domperidone, both dopamine antagonists. Ondansetron (Zofran) is a serotonin receptor antagonist and it's used for cancer patients undergoing chemotherapy because the irritation of the GI mucosa by the medication used in chemotherapy (which is cytotoxic and increase the levels of serotonin in the blood) are transmitted through the vagal nerve to the chemoreceptor trigger zone via activating serotonin receptors (5-HT3). It has no effect on dopamine receptors. "
So I guess meto still the best...

 

[jayfox]

I was wondering about this. Drugs.com reviews rates zofran (with 150 reviews) one of the most effective nausea drugs while meto (90 reviews) is significantly more negatively rated for that purpose. Thoughts?

View attachment 10796

https://www.drugs.com/condition/nausea-vomiting.html
I may get Zofran now actually, may be more effective.

EDIT:
Um I may have jumped the gun, seems like is zofran is effective is when used for cancer but they work differently so meto is more for a suicidal purpose...

"Metoclopramide is used by Dignitas and i think it's the recommened antiemetic in OD, the second one being domperidone, both dopamine antagonists. Ondansetron (Zofran) is a serotonin receptor antagonist and it's used for cancer patients undergoing chemotherapy because the irritation of the GI mucosa by the medication used in chemotherapy (which is cytotoxic and increase the levels of serotonin in the blood) are transmitted through the vagal nerve to the chemoreceptor trigger zone via activating serotonin receptors (5-HT3). It has no effect on dopamine receptors. "
So I guess meto still the best...

You're supposed to use both , I don't get it.

 

[spanishguy22]

You're supposed to use both , I don't get it.

what dont you get
its just that the reviews rates zofran a lot higer than meto, meto only gets 4 out of 10 its worrisome

 

[overandout]

Well I ran out of my antidepressants venlafaxine and became really nauseous and decided to use my meto as was feeling desperate it did help but then it became less affective and it really concerned me. I only used it twice but noticed the second time the nausea didn't go away. Thankfully got my meds renewed and made made huge difference. I'd be interested to see if zofran would have been more effective.

 

[Vegrau]

Meto were chosen mostly because of its prokinetic ability.

 

[overandout]

Meto were chosen mostly because of its prokinetic ability.

Ah ok thanks, didn't realise that.

 

[Vegrau]

Ah ok thanks, didn't realise that.

You cant puke out something thats no longer there.

 

[how2toGetout]

I was wondering about this. Drugs.com reviews rates zofran (with 150 reviews) one of the most effective nausea drugs while meto (90 reviews) is significantly more negatively rated for that purpose. Thoughts?

View attachment 10796

https://www.drugs.com/condition/nausea-vomiting.html
I may get Zofran now actually, may be more effective.

EDIT:
Um I may have jumped the gun, seems like is zofran is effective is when used for cancer but they work differently so meto is more for a suicidal purpose...

"Metoclopramide is used by Dignitas and i think it's the recommened antiemetic in OD, the second one being domperidone, both dopamine antagonists. Ondansetron (Zofran) is a serotonin receptor antagonist and it's used for cancer patients undergoing chemotherapy because the irritation of the GI mucosa by the medication used in chemotherapy (which is cytotoxic and increase the levels of serotonin in the blood) are transmitted through the vagal nerve to the chemoreceptor trigger zone via activating serotonin receptors (5-HT3). It has no effect on dopamine receptors. "
So I guess meto still the best...

Where can you buy Zofran without prescription in US? Are there any good websites that are legit?

 

[HGL91]

I hate Zofran. It gave me such a sharp headache.

 

[k75]

They work totally differently. I have a chronic condition with constant nausea and vomiting, and I have to take Zofran multiple times a day. It helps a ton, but only by taking away the urge to vomit. I still do sometimes, though, because stuff is still in my stomach.

With Reglan, it helps empty your stomach, so there's nothing in there to vomit. For my condition, Zofran is usually the better choice, but there have been a few times when I had to temporarily switch because it wasn't cutting it.

I recently asked on here about taking both together, and it can apparently be beneficial.