Yea humans were not wired to be alone, though people will give you bullshit about how you need to "love yourself" first etc. that's not how it works. We are social creatures. Even animals get depressed if they're not paired up. Medication and therapy have never even come close to the relief that a romantic/intimate relationship give me (until it broke down, of course, then I was worse off).
Making close friends as an adult is near-impossible, and it's not just depressed people who would agree w/ that statement. I think once you're out of college it's kind of over. Hobby groups and shared interests have only given me new acquaintances, but it seems like they already have their "core" friend groups from years ago.
I have made connections through the internet...i would not meet anyone from a site like this (no offense) but some of the discord friends I made during peak covid isolation have become irl acquaintances, which I'm grateful for. It was a large-ish server and I happened to find someone who lived in my city. But again not really best friends. Like my one online-turned-irl-friend primarily hangs out with their college and law school pals.
I'm sure I'm part of the problem too. I've never had very deep friendships, even as a child. But honestly lack of intimate companionship troubles me more than lack of friendships, which I think is also natural when you're an adult. Shooting the shit with friends only brings so much fulfillment