Method Clonazepam + metoprolol + alcohol + meto?

[KnightOfEnceladus]

This is a hypothetical since I don't have access to clonazepam or metoprolol (though I do have propranolol, which is the same class of drug, the beta-adrenergic antagonist).

Would this combination work? Say a stat dose of 40-60mg metoclopramide, followed an hour later by a month's supply of clonazepam, a month's worth of metoprolol, and one king hell mountain of a lot of ethanol, like an entire fifth of vodka? The meto is key to prevent the body from bringing the rest of that up.

I would think the mutually-potentiating GABAergic action of the clonazepam and alcohol, combined with the beta-antagonism of the metoprolol, would be enough to do the job, all kept safely down by the metoclopramide. But I'd really appreciate someone with more knowledge/experience than me weighing in on this. In particular, would the meto really keep all that down properly? And, would that be enough clonazepam to be lethal by itself?

 

[jake3d]

Benzos have a massive safety margin, so i don't think that much clonazepam alone will kill you. Mixed with booze tho, there is a good chance you'll stop breathing.

 

[jake3d]

Otoh you can od on propranolol alone if you have enough of it.

 

[Mysterymeat]

I think it may be unpredictable. You'd think you'd stop breathing but our bodies have this stupid way of compensating for nearly anything we use to try to damage it.

 

[KnightOfEnceladus]

@Mysterymeat, yeah, I don't trust single-med OD methods one little bit, not even nembutal. That's why I'm looking into a combination of massive GABA agonism, crazy beta-adrenergic blockade, and dopamine blockade (metoclopramide) to stop it all from coming back up. Maybe throw a few Benadryl in there for the H1 and ACHm antagonism as well.