Chloroquine

[dredd1981]

Hi guys, I'm looking to ctb using chloroquine, I've bought two boxes of tablets, 40 total. The 2022 ppeh says 40 tablets of 250mg should be fatal….but I found threads from 2019 saying this isn't the case, and the fatal dose is closer to 100 tablets….yet the most recent ppeh still says 40…..anyone have any advice?

 

[[HNO]]

ppeh is a book intended for elderly or serious ill so they've a reason to lower doses:

"Risk factors for toxicity
Risk of toxicity is increased in:
• patients with pre-existing cardiovascular disease
• the elderly."

so for a healthy person this dose supposedly should be higher than stated though:

"In adults, doses higher than 5 g are likely to be fatal,
although death may occur with lower doses."

also:

The use of diazepam in chloroquine poisoning - PubMed

A 39-year-old patient was found to be unconscious after having taken 2.5 g of chloroquine. Treatment consisted mainly of gastric lavage and diazepam. Experimental and clinical evidence is presented to show that diazepam in varying doses significantly decreases the mortality rate.

pubmed.ncbi.nlm.nih.gov

diazepam seems usable as an antidote so it's not advisable to mix w/

toxicity in rodents:
"Chloroquine phosphate 50-63-5 100 Toxicological Data on Ingredients: Chloroquine phosphate: ORAL (LD50): Acute: 500 mg/kg [Mouse]. 623 mg/kg [Rat]."

30g ought to be considered as dose that causes 50% lethality in humans according to rat toxicity model

some symptoms of poisoning(there's much more):

"•Cardiovascular: hypotension is common. Collapse and
cardiovascular failure with impaired cardiac output or
vasodilatation may result in organ failure. Cardiac fea-
tures may be worsened by co-ingestion of other car-
diotoxicants, including beta blockers, calcium channel
blockers, and sodium channel blockers.

• Gastrointestinal: nausea and vomiting are frequent.
Early vomiting may decrease gastrointestinal chloro-
quine absorption but may also precipitate aspiration
pneumonia."

antiemetics needed

 

[dredd1981]

Thanks for that, I think I'm going to have to buy more

 

[bkmngtr]

ppeh is a book intended for elderly or serious ill so they've a reason to lower doses:

"Risk factors for toxicity
Risk of toxicity is increased in:
• patients with pre-existing cardiovascular disease
• the elderly."

so for a healthy person this dose supposedly should be higher than stated though:

"In adults, doses higher than 5 g are likely to be fatal,
although death may occur with lower doses."

also:

The use of diazepam in chloroquine poisoning - PubMed

A 39-year-old patient was found to be unconscious after having taken 2.5 g of chloroquine. Treatment consisted mainly of gastric lavage and diazepam. Experimental and clinical evidence is presented to show that diazepam in varying doses significantly decreases the mortality rate.

pubmed.ncbi.nlm.nih.gov

diazepam seems usable as an antidote so it's not advisable to mix w/

toxicity in rodents:
"Chloroquine phosphate 50-63-5 100 Toxicological Data on Ingredients: Chloroquine phosphate: ORAL (LD50): Acute: 500 mg/kg [Mouse]. 623 mg/kg [Rat]."

30g ought to be considered as dose that causes 50% lethality in humans according to rat toxicity model

some symptoms of poisoning(there's much more):

"•Cardiovascular: hypotension is common. Collapse and
cardiovascular failure with impaired cardiac output or
vasodilatation may result in organ failure. Cardiac fea-
tures may be worsened by co-ingestion of other car-
diotoxicants, including beta blockers, calcium channel
blockers, and sodium channel blockers.

• Gastrointestinal: nausea and vomiting are frequent.
Early vomiting may decrease gastrointestinal chloro-
quine absorption but may also precipitate aspiration
pneumonia."

antiemetics needed

In the PPH they wrote that Although the volume of its lethal drink may be small, it is extremely bitter and anti-emetics are essential. Do you know whether they recommend anti-emetics due to the bitter taste (i.e. it would not be a problem if one were to take it in form of pills) or whether vomiting would occur as a natural reaction of the body.