Help Chlorhexidine and SN

[lambgf]

While I was doing my research on SN I stumbled across a comment by @notjustyetagain (thank you for the information!) with a link to an article which states that:

Treatment with chlorhexidine, a bis-biguanide antiseptic, produces a profound and lengthy alteration of the salty taste of all salty compounds.
Chlorhexidine is the only known blocker of salty taste in humans.
Results suggest that identification of stimuli that normally involve generation of salty and bitter tastes is severely disrupted by chlorhexidine treatment.

I was wondering if doing a chlorhexidine mouth rinse would help with the salty taste of SN and ease swallowing. Does anyone know of any attempts that mention the use of it? I couldn't find anything with the search function.

Original comment:

re the burning-throat issue, yes quite common. swallowed (i.e. whole-throat) numbing agents may interact badly with SN, but a numbing lozenge doesn't seem like a big risk. IIRC none of the accounts focus heavily on the throat pain or describe it as unbearable, sounds more like a low-/medium-strength unpleasant irritation... OTOH if it increases the risk of vomiting, a numbing agent might be a useful addition. would be nice to get rid of taste too. bizarre factoid: chlorhexidine, an antiseptic that's OTC in many countries, is the only known blocker of the human salty taste.

 

[Quarky00]

It appears a bit useless here ?

• Salty taste is on the back of the tongue, distinct but not a discomfort, and not a problem (use straw, nosh something, etc)
• Stinging throat is due to strong salt on sensitive membrane -- chlorhexidine won't solve that .

* I don't really know how to address burning .. Na+ and NH2- on epithelium.. dunno if it's chemoreceptors (sensory) or cell lysis