marcy2022
Student
- Oct 19, 2022
- 151
If I try to inject myself with vecuronium bromide at dosage of 2mg/1ml, total of 60mg/30ml using a syringe, would I be able to inject the whole solution before getting paralyed?
If yes, how long do I have from injecting the needle to getting paralyzed? (online research suggests, 2-4min, 0.5-1min, some suggests it works almost immidiately)
Anyway to slowdown the effects for like a min, so I have a chance to inject the whole 30ml solution and maybe even get rid of the syringe?
I was thinking maybe a tourniquet but according to this: https://pubmed.ncbi.nlm.nih.gov/8615509/
"The tourniquet was inflated to a pressure of 300 mm Hg. It was deflated 5 min later. In the vecuronium and mivacurium groups, the tourniquet did not influence onset of block."
"To explain that onset of block continues in spite of interruption of blood flow, drug molecules must gain access to the neuromuscular junction via routes other than the circulation."
"Drugs administered prior to pneumatic tourniquet inflation can be affected by tourniquet pressure release due to a transient change in pharmacokinetics and pharmacodynamics [2,3]. Neuromuscular blocking agent (NMBA), which is systemically distributed after administration, can be sequestered in the isolated limb when a Tourniquet is inflated and be reabsorbed into the systemic circulation after tourniquet release [3]. In addition, NMBA administered after pneumatic tourniquet inflation may not be delivered to isolated limbs and its pharmacokinetics may also be affected after tourniquet release. Changes in the NMBA effect may affect the reversibility of paralysis, altering the recovery period of general anesthesia"
"We conclude that during onset, neuromuscular block continued to increase in spite of interruption of blood flow, and this increase was greater with vecuronium"
The first and third link above suggests tourniquet has no effect on the onset of vecuronium and the second article suggests that tourniquet has minimal effects and/or it may complicate things to the point where the drug may not be as efftive as it would've been without tourniquet.
Tourniquet or not, is there anyway to slow down the effects of vecuronium so I can inject the whole 30ml solution and maybe have a few spare seconds to dispose of the syringe?
Also what if I'm sitting while injecting vecuronium and if I'm already paralyzed, would I have time to lie down?
After being paralyzed and gasping for air, could it make my face look as if I'm gasping for air? I would prefer not look like that if possbile.
If yes, how long do I have from injecting the needle to getting paralyzed? (online research suggests, 2-4min, 0.5-1min, some suggests it works almost immidiately)
Anyway to slowdown the effects for like a min, so I have a chance to inject the whole 30ml solution and maybe even get rid of the syringe?
I was thinking maybe a tourniquet but according to this: https://pubmed.ncbi.nlm.nih.gov/8615509/
"The tourniquet was inflated to a pressure of 300 mm Hg. It was deflated 5 min later. In the vecuronium and mivacurium groups, the tourniquet did not influence onset of block."
"To explain that onset of block continues in spite of interruption of blood flow, drug molecules must gain access to the neuromuscular junction via routes other than the circulation."
"Drugs administered prior to pneumatic tourniquet inflation can be affected by tourniquet pressure release due to a transient change in pharmacokinetics and pharmacodynamics [2,3]. Neuromuscular blocking agent (NMBA), which is systemically distributed after administration, can be sequestered in the isolated limb when a Tourniquet is inflated and be reabsorbed into the systemic circulation after tourniquet release [3]. In addition, NMBA administered after pneumatic tourniquet inflation may not be delivered to isolated limbs and its pharmacokinetics may also be affected after tourniquet release. Changes in the NMBA effect may affect the reversibility of paralysis, altering the recovery period of general anesthesia"
"We conclude that during onset, neuromuscular block continued to increase in spite of interruption of blood flow, and this increase was greater with vecuronium"
The first and third link above suggests tourniquet has no effect on the onset of vecuronium and the second article suggests that tourniquet has minimal effects and/or it may complicate things to the point where the drug may not be as efftive as it would've been without tourniquet.
Tourniquet or not, is there anyway to slow down the effects of vecuronium so I can inject the whole 30ml solution and maybe have a few spare seconds to dispose of the syringe?
Also what if I'm sitting while injecting vecuronium and if I'm already paralyzed, would I have time to lie down?
After being paralyzed and gasping for air, could it make my face look as if I'm gasping for air? I would prefer not look like that if possbile.
