Resource Yer own SN Masterplan

[Hydra]

Will I tell you how to do it? No. I'll try to show you how you can come up with your own plan of SN Method using medications that are reachable to you the most, sometimes in the off-label way.

Do I have an actual knowledge to write any tutorial at all? Well, yes. But I'm not an expert.

1. Resources you will need.

Absolutely essential: SN. Aka sodium nitrite. NaNO2. Not sodium nitrate, not sodium chloride. Nitrite. At least 98% pure. 15-20 grams of powder.


Optional: Let's lower the risk of puking everything out and ruining our trip to the Elysium fields.
Because what happens when you mix your gastric acid with SN? A lot of sodium chloride/kitchen salt will come up. Ingesting a high dose of salt provokes vomiting- this trick is used among human and animal medicine field and low key alcoholic college students. This is what we can do about it:

1. Use Dopamine2 receptor antagonist.

Effect: your stomach will scream but the brain won't hear it

The strongest antinausea medications will include dromperidone and metoclopramide.
Oh, hell yes. But don't clinge on just a few substances when you have plenty to choose from. Especially if they're not so easy obtainable- they're usually prescribed for patients with migraines/post chemotherapy nausea/vomiting.

You can use any D2 receptor antagonist as an off-label antiemetic if it's strong enough.
How can we know when the drug is strong enough?
By it's inhibitory constant (Ki). The LOWER the Ki towards D2 receptors the stronger antiemetic effect. For the strongest antinauseous drugs Ki is under 1 nM. I'd say that any drug with Ki < 50 nM would be remarkable helpful.
I know it sounds like a stuff and nonsense but these informations are usually easy to find on Wikipedia for example.


TL:DR- the lower the numbers next to the drugs I'm mentioning here, the more powerful antiemetic the substance is.

Well-known antiemetics:

Dromperidone 0,3 nM
Metoclopramide 28,8 nM
Olanzapine 3.00-106 nM (lol don't ask me)
Alizapramide 200 nM
Chlorpromazine
Prochlorperazine

1st generation antipsychotics

Droperidol- 0,25 nM
Benperidol- 0,027 nM
Trifuperidol- 0,4 nM
Spiperone- 0,053 nM
Haloperidol- 2,0
Bromperidol- 2,1

2nd generation antipsychotics

Lurasidone- 1,0 nM
Sestindole- 2,7 nM
Paliperidone- 2,8 nM
Risperidone- 4,9 nM
Olanzapine- 21 nM
And some meh:
Clozapine- 144 nM
Quetiapine- 245 nM

Atypical antipsychotics

Aripiprazole- 0,34 nM
Brexipiprazole- 0,30 nM
Cariprasine- 0,49 nM

1. Use proton pomp-pump inhibitor

Effect: Your stomach will scream but muffled with a ballgag.
It will lower your HCl level> less NaCl> tummy gets less salty

Examples: Dexlansoprazole, Pantoprazole, Rabeprazole
(OTC in USA): Omeprazole, Lansoprazole, Esomeprazole

1. (If you need to) Sedatives- because why the fuck not. Because who wants to cry their eyes out during their (last) panic attack?

Benzodiazepines:
Personally I'd suggest using benzodiazepines because:
-no interactions with antiemetics nor proton-pump inhibitors
-mild anti-vomit effect
How to obtain: Doc, I have anxiety and panic attacks. (This is literally what I said to my first contact doctor when I got prescribed alprazolam just like that).

Opioids: cool option, especially for Americans. Tragically opioids can trigger psychosis and dramatically increase the risk of vomiting. Don't risk if you're not an experienced opiowreck. If it would be your first time with opios- you WILL BE AT LEAST NAUSEOUS and it will hardly be a good time.

Pot: super mild anti vomit effect, seems like a good option. Risk of a bad trip.

Alcohol: the more you drink the higher is the chance of vomit. Can interact with most of 1A drugs causing dizziness, nausea, blackout and such. You might not be able to get things done if you drink too much.

Antipsychotics: if you're already on antipsychotics you may not need any other sedatives. Be careful with dosage and listen to your organism if you still insist to take some. You're the one who knows your organism the best.


2. Check out for interactions between your chosen medications for SN method AND ANY DRUGS YOU HAPPEN TO TAKE

This step couldn't be any easier. Go to this idiot-friendly site and just enter all of your your drugs.
https://www.drugs.com/drug_interactions.html

In my case the list will look like this:

Venlafaxine and lamotrigine are the medications I take daily.
The rest is my way out. Click "check for interactions"
Read carefully through the interactions. Some of them might seem scary like this for example:

And then you remember that this is exactly what you're aiming for (hellyeah.gif)

Yet some of the interactions can be awful and far from being helpful. Thus, unfortunately, for some of you it may be very difficult to find a proper combination. I guess that most of us is able to deal with slight inconveniences like dizziness, headaches etc. But some of them can get really bad. Save yourself more suffering.


And three words for any bright crystal mind that's going to take horrendous amounts of anti-emetics:
NEUROLEPTIC MALIGNANT SYNDROME

Sounds ugly itself, huh? It's lethal (but not enough), it's rare, but if you're stubborn enough…So if you wish to wait for that bus with a smile on your face it would be the best to stay away from the following combinations:

METOCLOPRAMIDE/DOMPERIDONE + high doses of NEUROLEPTICS
Especially typical antipsychotics (eg. Haloperidol)
Atypical antipsychotics (like Clozapine, Olnazapine) have little potential to induce NMS, but keep in mind that high dose of atypicals mixed with high dose of D2 antagonist might become dangerous.

-If you're already on a high dose of strong neuroleptics with low Ki you may cease using metoclopramide/domperidone.
-If you're on neuroleptics with low Ki, like quetiapine for example, I'd personally suggest talking to your doc to get prescribed something with lower Ki.

METOCLOPRAMIDE + DOMPERIDONE
One question: Why?
Side effects? Gotta catch'em all?

Adjust the drug combination to your needs and harsh reality.

4. Evaluating the plan

Forget about swallowing pints of medications. Forget about starting the regime a week (lol) before your exit date. The drug would only accumulate in your organism to some batshit crazy level flooding you with severe side effects and only slightly better 'therapeutic' effect.

I strongly advice to do this step AFTER you obtain all the medication you need. It's because the pharmaceutical form of the same substance may vary depending of producer.

For example let's say that I've decided to use domperidone as antiemetic before ingesting sodium nitrite solution.

1.Find on the internet producer's data sheet.
https://www.medsafe.govt.nz/profs/Datasheet/m/motiliumtab.pdf

2.We will need data such as:

• quantity of active substance per each tablet - 10mg of domperidone
• maximum daily dose- 30 mg, up to 40 mg orally
• peak of concentration- after 30-60 minutes (see: Absorption; key words: peak plasma concentration)
• ability to accumulation (see: Distribution; key words "Oral domperidone does not appear to accumulate")

3.Now let's interpret this gibberish.
I'll be taking 3 tabletes of Motilium 30-60 minutes before ingesting sodium nitrite.
Long regime would have no sense since domperidone does not accumulate.

4. Repeat above with every drug you're going to take

5. Compare peaks of concentration

Let's say we're very ambitious/paranoid and our list is quite long:

Drug A- peak after 40 minutes taken orally
Drug B- peak after 15 minutes taken orally
Drug C- peak after 6 hours taken orally

Place them in order from the highest to the lowest time of onset

1. Drug C
2. Drug A
3. Drug B

The rule is simple- peak of every drug should occur at the moment of SN ingestion.

6. Enjoy your own, unique masterplan

1. Drug C 8:00 AM
2. Drug A 1:20 PM
3. Drug B 1:45 PM
4. Sodium nitrite 2:00 PM

I hope that some of you will find this morally dubious post helpful. Like I said- I didn't want to create another strict recipe because there are millions of options and possible complications. SN Megathread is a mess (sorry) and methods presented by individual users are the best methods. Umm for them. They're reaaaallly great to lean on, but every person is different and sometimes the choice is very limited.

So if you already have an idea just stand in front of the mirror, smile and say to yourself:





also sorry for my language i'm in the middle of mental breakdown, i'm drunk, and i'm not even a native speaker

 

[JimFord99]

I agree with Stan.

 

[Astral316]

Fuck yea! The Elysium fields here we come!

 

[Rachel74]

I agree with Stan.

Me too x

 

[Trainwreck]

I know some people get sick of all the SN posts, but personally, I find them very helpful. A lot of info (and questions) get lost in the megathread. Thank you for all the great info!

 

[Ἡγησίας]

Great contribution, thanks for sharing! A couple of notes... there is no THC weed (high in CBD), could It work stopping nausea as good as a standar weed does? And other thing, what do you think about putting SN in capsules? Is this a way to avoid the use of antiemetics or are they a must if you are not under antipsychotics treatment?

My idea would be to take encapsulated SN ten minutes after ingesting 4 or 5 mg of benzos (alprazolam or lorazepam).

 

[Rachel74]

SN is a easy and chesp way out hence why it's so popular. I
Think threads like this need to be here to give us a choice.

 

[sleepy dog]

All you did was take the known working method in the PPH and add a sedative, but no sedative is needed. But your post has probably confused and intimidated some into not using SN.

 

[Heart of Ice]

Thank you for this post! My plan is very similar.

 

[Sunset Limited]

Will I tell you how to do it? No. I'll try to show you how you can come up with your own plan of SN Method using medications that are reachable to you the most, sometimes in the off-label way.

Do I have an actual knowledge to write any tutorial at all? Well, yes. But I'm not an expert.

1. Resources you will need.

Absolutely essential: SN. Aka sodium nitrite. NaNO2. Not sodium nitrate, not sodium chloride. Nitrite. At least 98% pure. 15-20 grams of powder.


Optional: Let's lower the risk of puking everything out and ruining our trip to the Elysium fields.
Because what happens when you mix your gastric acid with SN? A lot of sodium chloride/kitchen salt will come up. Ingesting a high dose of salt provokes vomiting- this trick is used among human and animal medicine field and low key alcoholic college students. This is what we can do about it:

1. Use Dopamine2 receptor antagonist.

Effect: your stomach will scream but the brain won't hear it

The strongest antinausea medications will include dromperidone and metoclopramide.
Oh, hell yes. But don't clinge on just a few substances when you have plenty to choose from. Especially if they're not so easy obtainable- they're usually prescribed for patients with migraines/post chemotherapy nausea/vomiting.

You can use any D2 receptor antagonist as an off-label antiemetic if it's strong enough.
How can we know when the drug is strong enough?
By it's inhibitory constant (Ki). The LOWER the Ki towards D2 receptors the stronger antiemetic effect. For the strongest antinauseous drugs Ki is under 1 nM. I'd say that any drug with Ki < 50 nM would be remarkable helpful.
I know it sounds like a stuff and nonsense but these informations are usually easy to find on Wikipedia for example.


TL:DR- the lower the numbers next to the drugs I'm mentioning here, the more powerful antiemetic the substance is.

Well-known antiemetics:

Dromperidone 0,3 nM
Metoclopramide 28,8 nM
Olanzapine 3.00-106 nM (lol don't ask me)
Alizapramide 200 nM
Chlorpromazine
Prochlorperazine

1st generation antipsychotics

Droperidol- 0,25 nM
Benperidol- 0,027 nM
Trifuperidol- 0,4 nM
Spiperone- 0,053 nM
Haloperidol- 2,0
Bromperidol- 2,1

2nd generation antipsychotics

Lurasidone- 1,0 nM
Sestindole- 2,7 nM
Paliperidone- 2,8 nM
Risperidone- 4,9 nM
Olanzapine- 21 nM
And some meh:
Clozapine- 144 nM
Quetiapine- 245 nM

Atypical antipsychotics

Aripiprazole- 0,34 nM
Brexipiprazole- 0,30 nM
Cariprasine- 0,49 nM

1. Use proton pomp-pump inhibitor

Effect: Your stomach will scream but muffled with a ballgag.
It will lower your HCl level> less NaCl> tummy gets less salty

Examples: Dexlansoprazole, Pantoprazole, Rabeprazole
(OTC in USA): Omeprazole, Lansoprazole, Esomeprazole

1. (If you need to) Sedatives- because why the fuck not. Because who wants to cry their eyes out during their (last) panic attack?

Benzodiazepines:
Personally I'd suggest using benzodiazepines because:
-no interactions with antiemetics nor proton-pump inhibitors
-mild anti-vomit effect
How to obtain: Doc, I have anxiety and panic attacks. (This is literally what I said to my first contact doctor when I got prescribed alprazolam just like that).

Opioids: cool option, especially for Americans. Tragically opioids can trigger psychosis and dramatically increase the risk of vomiting. Don't risk if you're not an experienced opiowreck. If it would be your first time with opios- you WILL BE AT LEAST NAUSEOUS and it will hardly be a good time.

Pot: super mild anti vomit effect, seems like a good option. Risk of a bad trip.

Alcohol: the more you drink the higher is the chance of vomit. Can interact with most of 1A drugs causing dizziness, nausea, blackout and such. You might not be able to get things done if you drink too much.

Antipsychotics: if you're already on antipsychotics you may not need any other sedatives. Be careful with dosage and listen to your organism if you still insist to take some. You're the one who knows your organism the best.


2. Check out for interactions between your chosen medications for SN method AND ANY DRUGS YOU HAPPEN TO TAKE

This step couldn't be any easier. Go to this idiot-friendly site and just enter all of your your drugs.
https://www.drugs.com/drug_interactions.html

In my case the list will look like this:

Venlafaxine and lamotrigine are the medications I take daily.
The rest is my way out. Click "check for interactions"
Read carefully through the interactions. Some of them might seem scary like this for example:

And then you remember that this is exactly what you're aiming for (hellyeah.gif)

Yet some of the interactions can be awful and far from being helpful. Thus, unfortunately, for some of you it may be very difficult to find a proper combination. I guess that most of us is able to deal with slight inconveniences like dizziness, headaches etc. But some of them can get really bad. Save yourself more suffering.


And three words for any bright crystal mind that's going to take horrendous amounts of anti-emetics:
NEUROLEPTIC MALIGNANT SYNDROME

Sounds ugly itself, huh? It's lethal (but not enough), it's rare, but if you're stubborn enough…So if you wish to wait for that bus with a smile on your face it would be the best to stay away from the following combinations:

METOCLOPRAMIDE/DOMPERIDONE + high doses of NEUROLEPTICS
Especially typical antipsychotics (eg. Haloperidol)
Atypical antipsychotics (like Clozapine, Olnazapine) have little potential to induce NMS, but keep in mind that high dose of atypicals mixed with high dose of D2 antagonist might become dangerous.

-If you're already on a high dose of strong neuroleptics with low Ki you may cease using metoclopramide/domperidone.
-If you're on neuroleptics with low Ki, like quetiapine for example, I'd personally suggest talking to your doc to get prescribed something with lower Ki.

METOCLOPRAMIDE + DOMPERIDONE
One question: Why?
Side effects? Gotta catch'em all?

Adjust the drug combination to your needs and harsh reality.

4. Evaluating the plan

Forget about swallowing pints of medications. Forget about starting the regime a week (lol) before your exit date. The drug would only accumulate in your organism to some batshit crazy level flooding you with severe side effects and only slightly better 'therapeutic' effect.

I strongly advice to do this step AFTER you obtain all the medication you need. It's because the pharmaceutical form of the same substance may vary depending of producer.

For example let's say that I've decided to use domperidone as antiemetic before ingesting sodium nitrite solution.

1.Find on the internet producer's data sheet.
https://www.medsafe.govt.nz/profs/Datasheet/m/motiliumtab.pdf

2.We will need data such as:

• quantity of active substance per each tablet - 10mg of domperidone
• maximum daily dose- 30 mg, up to 40 mg orally
• peak of concentration- after 30-60 minutes (see: Absorption; key words: peak plasma concentration)
• ability to accumulation (see: Distribution; key words "Oral domperidone does not appear to accumulate")

3.Now let's interpret this gibberish.
I'll be taking 3 tabletes of Motilium 30-60 minutes before ingesting sodium nitrite.
Long regime would have no sense since domperidone does not accumulate.

4. Repeat above with every drug you're going to take

5. Compare peaks of concentration

Let's say we're very ambitious/paranoid and our list is quite long:

Drug A- peak after 40 minutes taken orally
Drug B- peak after 15 minutes taken orally
Drug C- peak after 6 hours taken orally

Place them in order from the highest to the lowest time of onset

1. Drug C
2. Drug A
3. Drug B

The rule is simple- peak of every drug should occur at the moment of SN ingestion.

6. Enjoy your own, unique masterplan

1. Drug C 8:00 AM
2. Drug A 1:20 PM
3. Drug B 1:45 PM
4. Sodium nitrite 2:00 PM

I hope that some of you will find this morally dubious post helpful. Like I said- I didn't want to create another strict recipe because there are millions of options and possible complications. SN Megathread is a mess (sorry) and methods presented by individual users are the best methods. Umm for them. They're reaaaallly great to lean on, but every person is different and sometimes the choice is very limited.

So if you already have an idea just stand in front of the mirror, smile and say to yourself:
View attachment 16606




also sorry for my language i'm in the middle of mental breakdown, i'm drunk, and i'm not even a native speaker

Thanks for information. If I understand correctly, a 48-hour regimen with domperidone is unnecessary. I think the regimen might be useful for metoclopramide. Is metoclopramide better with a 48-hour regimen or domperidone with a 30mg stat dose?

 

[Stan]

Please concentrate on the top two lines of the post. The OP is telling how you could put together a plan, not that this is the plan. And as stated in other threads, Dignitas in Switzerland only do a stat dose some time before they give the N, you can take that fact or ignore it, down to whoever reads it

 

[Trainwreck]

I just filled out that little drug interaction thingy, and tylenol + SN = increase risk of methemoglobinemis. That's handy, as I'm going to take Tylenol to see if it will help lessen the headache.

 

[GrizzlyGrapefruit]

you need to) Sedatives- because why the fuck not. Because who wants to cry their eyes out during their (last) panic attack?

Great post! I'm currently trying to get my hands on some benzos from my doc, and reading what you wrote about your experience is very reassuring. Wish me luck!

 

[babydeer]

Is there a specific source from Amazon/Ebay/etc that people favor? I'm reading up as much as I can on SN and I'm trying to cover all my bases...

 

[Stan]

Is there a specific source from Amazon/Ebay/etc that people favor? I'm reading up as much as I can on SN and I'm trying to cover all my bases...

Just look at the seller reviews, they will give you trust

 

[Hydra]

Thank you for all the praises.
I'll answer any questions once I get home + might add few things.

 

[khw777]

Thank you for all the praises.
I'll answer any questions once I get home + might add few things.

Can you use Reglan instead of metro?