Help Would meto lessen the absorption of SN in this case?

[Shakespear's Brother]

Shortly after I took the stat dose of 30mg meto, I experienced 3 episodes of high volume diarrhea.

This wasn't surprising, because diarrhea is a known common side effect of meto, with a 1-10% occurrence, according to drugs[.]com

But it is concerning to me, considering how the body produces diarrhea, by basically sucking up all the liquid available in the digestive track and quickly moving it into the large intestine and then expelling it.

Is it possible in this case that the SN liquid will not be absorbed? That it will pass too quickly through the small intestine to allow full absorption to take place?

 

[Neverod]

Intestines are about 5-7 meters long, so i don't think that it would suck it up and extract it instantly. It should have plenty of time to be absorbed.
Maybe you won't get that side effect (or not so strong) if you do the 48h regimen, 1x10mg meto every 8 hours, so that way you don't have to do the stat dose, and won't pass out in the toilet when ingesting the SN.

 

[Shakespear's Brother]

Intestines are about 5-7 meters long, so i don't think that it would suck it up and extract it instantly.

This would seem like a logical conclusion and it's one I thought about.

The problem is, the way meto stimulates gastric emptying (a plus when it comes to wanting to get the SN liquid into the small intestine to be absorbed) can cause the muscles and whatnot that control the entirety of the intestines to become overactive, which greatly speeds up the process of moving liquid through them to be expelled.

This is how people who have chronic diarrhea become malnourished: because nutrients simply flow right through the small intestine without being absorbed.

 

[BPD_LE]

Could you try a different AE or get your hands on a dopamine blocking antipsycotic?

 

[Shakespear's Brother]

Could you try a different AE or get your hands on a dopamine blocking antipsycotic?

Not easily, if at all.

I'd really like to completely rule out meto as a possibility before expending effort and more money on an alternative.

I mean, logically, I would think that the small intestine would very readily absorb 50ml of water, which is just such a tiny amount of water after all, after being deprived as a result of the fast.

Like Stan mentioned, the body after a fast would be thirsty for hydration.

So it seems logical if this is the case, that the small intestine would be 'thirsty' and hopefully that would give priority to absorbing the SN liquid rather than immediately just passing it through?

 

[BPD_LE]

Not easily, if at all.

I'd really like to completely rule out meto as a possibility before expending effort and more money on an alternative.

I mean, logically, I would think that the small intestine would very readily absorb 50ml of water, which is just such a tiny amount of water after all, after being deprived as a result of the fast.

Like Stan mentioned, the body after a fast would be thirsty for hydration.

So it seems logical if this is the case, that the small intestine would be 'thirsty' and hopefully that would give priority to absorbing the SN liquid rather than immediately just passing it through?

Yes I agree.

 

[Shakespear's Brother]

This so fucking frustrating to me, because if I ended up foiled by diarrhea. I WILL SCREAM.

won't pass out in the toilet when ingesting the SN

This made me laugh, because fuck that would suck. Jesus. Forget my idea of dying with dignity, right?

 

[Shakespear's Brother]

@Stan, do you have any wise words on this?

 

[BleedingHeart]

Shortly after I took the stat dose of 30mg meto, I experienced 3 episodes of high volume diarrhea.

This wasn't surprising, because diarrhea is a known common side effect of meto, with a 1-10% occurrence, according to drugs[.]com

But it is concerning to me, considering how the body produces diarrhea, by basically sucking up all the liquid available in the digestive track and quickly moving it into the large intestine and then expelling it.

Is it possible in this case that the SN liquid will not be absorbed? That it will pass too quickly through the small intestine to allow full absorption to take place?

Were you in the middle of attempting CTB when this happened?

 

[Shakespear's Brother]

Oh gosh no. Was a test run to determine how my body would react.

 

[Mrnobody2019]

Not easily, if at all.

I'd really like to completely rule out meto as a possibility before expending effort and more money on an alternative.

I mean, logically, I would think that the small intestine would very readily absorb 50ml of water, which is just such a tiny amount of water after all, after being deprived as a result of the fast.

Like Stan mentioned, the body after a fast would be thirsty for hydration.

So it seems logical if this is the case, that the small intestine would be 'thirsty' and hopefully that would give priority to absorbing the SN liquid rather than immediately just passing it through?

Do we avoid water during the fast?

 

[BPD_LE]

Do we avoid water during the fast?

Only in the last couple of hours before SN

 

[Daniela]

extreme fatigue + diarrhea sounds like a regular menstrual period

Very convenient excuse. In my experience, people - including MY BROTHER - immediately flee the room the moment one says "I'm on my period"

 

[Stan]

@Stan, do you have any wise words on this?

Technically you are right. One of the treatments for diarrhoea is actually drinking water with salts (as sold in pharmacies) in it to replenish the body. Hate to experiment on you but what does 10mg do for you? Maybe lower the dose if you are sensitive to it. Will still have a positive effect.

 

[dominodux]

Shortly after I took the stat dose of 30mg meto, I experienced 3 episodes of high volume diarrhea.

This wasn't surprising, because diarrhea is a known common side effect of meto, with a 1-10% occurrence, according to drugs[.]com

But it is concerning to me, considering how the body produces diarrhea, by basically sucking up all the liquid available in the digestive track and quickly moving it into the large intestine and then expelling it.

Is it possible in this case that the SN liquid will not be absorbed? That it will pass too quickly through the small intestine to allow full absorption to take place?

You may take trimebutine, that increase the water absorbtion from the intestinal tract. Is often also used like antidiarroical. Two caps, would do the job.

A cocktail of 2 caps of loperamide, 2 caps of trimebutine, 2 caps of rifaximin.. and a person wont see the toilet for one week.
Experimented on myself, bcause i suffer IBS. I take this cocktail before traveling and usually get back from the journey after a few days and still didnt go to toilet.

 

[Daniela]

Would taking an anti-diarrhea otc (eg. Imodium) before the regimen prevent absorption of meto?

 

[Shakespear's Brother]

One of the treatments for diarrhoea is actually drinking water with salts (as sold in pharmacies) in it to replenish the body. Hate to experiment on you but what does 10mg do for you? Maybe lower the dose if you are sensitive to it. Will still have a positive effect.

Thanks so much, Stan. I will give that a test run this weekend and see how I fare.

You may take trimebutine, that increase the water absorbtion from the intestinal tract. Is often also used like antidiarroical. Two caps, would do the job.

A cocktail of 2 caps of loperamide, 2 caps of trimebutine, 2 caps of rifaximin.. and a person wont see the toilet for one week.
Experimented on myself, bcause i suffer IBS. I take this cocktail before traveling and usually get back from the journey after a few days and still didnt go to toilet.

Thanks dominodux. I also had given some thought to loperamide, in particular, as I've used that in the past to stop diarrhea and it's been quite effective.

My concern with using any kind of anti-diarrheal would be wondering if it would somehow negatively impact gastric emptying, so as to slow down the stomach emptying into the small intestine. @Stan, would you happen to know?

 

[Daniela]

As far as I can understand, loperamide decreases movement in the large intestine, thus prolonging the time stool stays inside it and allowing water to be absorbed out of it. By the time anything makes it to the large intestine, I understand most of it has already been broken down and absorbed - stool is undigested stuff (i.e. fiber) and water.

 

[dominodux]

Thanks so much, Stan. I will give that a test run this weekend and see how I fare.


Thanks dominodux. I also had given some thought to loperamide, in particular, as I've used that in the past to stop diarrhea and it's been quite effective.

My concern with using any kind of anti-diarrheal would be wondering if it would somehow negatively impact gastric emptying, so as to slow down the stomach emptying into the small intestine.

Not the medications i indicated:

1) Trimebutine increase water absorbtion into intestinal track
2) Loperamide just make the intestine "sleep" slowing bowel movements (but wont stop his operation of absorbtion)
3) Rifaximine just attacks some bacteria developed into intestine when is in irritation state

For what i know, none of this will slow down digestion and chemical absorb, not sure indeed about possible interaction with SN, but i wont see any reason for slowing down the process, instead.. vomit and diharrea are always reactions that drive chemicals quickly outside body.

 

[Holloet]

I know this thread is a year old, but I'm curious about this. Would having diarrhea impact SN absorption?

 

[hʚll]

Would having diarrhea impact SN absorption?

wondering too.
also if one was to try sn suicide outside without toilet .. like what . am scared
i guess i will hope to be lucky for once in my life, to not feel that symptom............??