Method Why are sleeping pills no longer affective?

[TANETS]

I know of a hand full of celebrities / public figures who ctb using sleeping pills before the 2000s, so I was surprised to find out that oding on sleeping pills has a very low success rate.

Were the formulas changed or something?

 

[lilah]

i think they took out the pentobarbiturate

 

[Tuonetar_]

Many have been reformulated, yes, but the prescribed dosages have also gotten a LOT smaller as well. Nowadays the standard dose for a z-drug like zolpidem is typically ~5mg, but back in the late 80s/early 90s doctors were prescribing twice as much, or instructing patients to take double doses. Sleeping pills are also notorious for negatively interacting with other things, namely alcohol, and a lot of prominent overdose deaths also involve alcohol/painkillers/etc.

 

[Marco77]

Because they replaced barbiturates with benzodiazepines. Benzodiazepines are much safer, and it is practically impossible to commit suicide. With barbiturates, a few tablets with a glass of whiskey were enough.

In clinical practice, barbiturates appear to be more dangerous than benzodiazepines, and this can be traced back to their respective mechanisms of action. Benzodiazepines increase the opening frequency of GABAA channel receptors in a GABA-dependent manner, while barbiturates increase the opening time and permeability to Cl- ions by interacting directly on the channel even in the absence of GABA. For this class of drugs, therefore, the control effect operated by natural neuronal activity is lost, and this is why barbiturates can induce serious effects such as coma at doses relatively close to therapeutic ones, while the doses of benzodiazepines necessary to have neurodepressant effects serious are very far from therapeutic doses.

 

[maniac116]

There used to be deadly barbiturate ODs with barbiturates so the medical community started using benzos & other meds that are "safer" (liability).