if you're referring to what i think you are; to my knowledge, the 48hr regimen and stat regimen have no discernible difference in effectiveness from what I've read. the only thing noteworthy that I can think of is the 48hr regimen will possibly open you up to some of the side effects Meto can cause, since you're taking it for longer as opposed to a single dose. Meto actually has some very nasty conditions it can cause, which is why hospitals and doctors will try to use other antiemetics first or only prescribe it for a short time. though these other AEs are not useful for SN, since most of them do not act on the D2 receptor which is why Meto or Domperidone is typically chosen (as well as some select antipsychotic meds).