what prescription drug can be the most fatal?

[SufferingInDenmark]

title

 

[SchizoGymnast]

Digoxin packs a punch

 

[SomewhatLoved]

Here are some that come to mind in a somewhat organized order (more pleasant to less pleasant).

1. propofol

used in MAID and surgery as general anaesthesia, especially paired with paralytics this will pretty much always be fatal in correct dosage. Only "prescribed" for in-hospital use in surgery or for emergency analgesia​

2. pentobarbital or other barbiturates

this is discussed a lot on this forum. Strong depressant, stops breathing > cardiac arrest. Again, dosage is important but this applies to everything on this list.​

3. insulin

See the Advanced Cardiovascular Life Support (ACLS) reversible causes of arrest. Hypoglycemia (low blood sugar) is one of the causes, and insulin causes this. It surprised me to learn this, but it is actually not very uncommon for diabetics with mental disorders to attempt suicide this way. It is reversible, but if you are not found it can certainly kill you.​

4. carfentanil/fentanyl

Slows or STOPS breathing in high doses > cardiac arrest. Some will say that opioids are not reliable. To that I say yes the fuck they are. The issue is dosage reliability of street drugs, but if you test it to be a certain concentration and take excess of the lethal dose it will kill you.​

5. alprazolam (xanax)

Common in "polypharmacy" overdoses. Benzos and opioids will potentiate each other, and are extremely dangerous when used together. Many severe overdoses often involve both these drug types.​

6. tricyclic antidepressants (TCAs)

Cardiotoxic (heart poison, essentially). Causes your heart to develop arrhythmias that do not circulate enough blood and you die.​

7. cardiac glycosides (digoxin, digitalis)

Similar to TCAs, interfere with electrolytes within the result and can result in worsening arrhythmias and death.​

Probably missing some but this is just what comes to mind quickly. A lot of these are "prescription" meds in the sense that they can technically be "prescribed", but either are not commonly used OR are only used realistically within hospital settings.

Please keep in mind that mixing drugs is not always a good idea, as certain effects may countereffect one another. For example, don't think that just because xanax and TCAs are both potentially lethal you should try them both. TCA overdoses often involve seizures, and xanax can be used to treat seizures, Research is always recommended.

 

[Worndown]

What do you have the ability to get?

 

[TheShadowQueen]

OxyContin & Percocet bonus points if you get it from a dealer that cut it with fentanyl

 

[Ijustcantanymore]

Propranolol, my roommate was almost successful with that

 

[blacksand]

I'd stick with either opioids, barbiturates or propofol. Anything else should be used for SI and nothing more. If it adds to a lethal cocktail then great.

 

[SufferingInDenmark]

What do you have the ability to get?

oh idk... hypothetically xanax and tramadol i think

 

[noheart]

I tried insulin, almost injected the entire vial and someone found me 1.5 hours later. I was still alive just felt like I was drunk. There was no pain, if I try again I will use 2 vials of fast acting with all the syringes preloaded.

 

[SufferingInDenmark]

I tried insulin, almost injected the entire vial and someone found me 1.5 hours later. I was still alive just felt like I was drunk. There was no pain, if I try again I will use 2 vials of fast acting with all the syringes preloaded.

how many syringe fulls does it take to empty a full vial?

 

[noheart]

I didn't count. Too many (ballpark was prolly 20) I just grabbed handful at a time and pushed them into my stomach subq.

 

[karakoltriste]

Strong opiate + benzo

 

[SadBumblebee]

I didn't count. Too many (ballpark was prolly 20) I just grabbed handful at a time and pushed them into my stomach subq.

I imagine that would be quite painful

 

[cazza82]

Propranolol, my roommate was almost successful with that

Really I have a lot of propanalol do they really work

 

[NearlyIrrelevantCake]

Why ODs Fail Miserably (A Guide)

There's still a lot of questions and inquiries about ODs, and people asking about what things may facilitate a successful attempt. Let's be clear, ODs are rarely fatal. Why? For a couple of reasons: (1) modern medications are designed to be very safe, as manufacturers aim to avoid deaths that...

sanctioned-suicide.net

Non-methods that should not be attempted

mod note: this has been added to the suicide resource compilation at the top. This has been made in response to the ever increasing amount of posts made about highly unlikely methods. Please read before posting about one of these methods or feel free to link if someone does post about them...

sanctioned-suicide.net

 

[tiredoflife2]

Here are some that come to mind in a somewhat organized order (more pleasant to less pleasant).

1. propofol

used in MAID and surgery as general anaesthesia, especially paired with paralytics this will pretty much always be fatal in correct dosage. Only "prescribed" for in-hospital use in surgery or for emergency analgesia​

2. pentobarbital or other barbiturates

this is discussed a lot on this forum. Strong depressant, stops breathing > cardiac arrest. Again, dosage is important but this applies to everything on this list.​

3. insulin

See the Advanced Cardiovascular Life Support (ACLS) reversible causes of arrest. Hypoglycemia (low blood sugar) is one of the causes, and insulin causes this. It surprised me to learn this, but it is actually not very uncommon for diabetics with mental disorders to attempt suicide this way. It is reversible, but if you are not found it can certainly kill you.​

4. carfentanil/fentanyl

Slows or STOPS breathing in high doses > cardiac arrest. Some will say that opioids are not reliable. To that I say yes the fuck they are. The issue is dosage reliability of street drugs, but if you test it to be a certain concentration and take excess of the lethal dose it will kill you.​

5. alprazolam (xanax)

Common in "polypharmacy" overdoses. Benzos and opioids will potentiate each other, and are extremely dangerous when used together. Many severe overdoses often involve both these drug types.​

6. tricyclic antidepressants (TCAs)

Cardiotoxic (heart poison, essentially). Causes your heart to develop arrhythmias that do not circulate enough blood and you die.​

7. cardiac glycosides (digoxin, digitalis)

Similar to TCAs, interfere with electrolytes within the result and can result in worsening arrhythmias and death.​

Probably missing some but this is just what comes to mind quickly. A lot of these are "prescription" meds in the sense that they can technically be "prescribed", but either are not commonly used OR are only used realistically within hospital settings.

Please keep in mind that mixing drugs is not always a good idea, as certain effects may countereffect one another. For example, don't think that just because xanax and TCAs are both potentially lethal you should try them both. TCA overdoses often involve seizures, and xanax can be used to treat seizures, Research is always recommended.

Good info

 

[quietwoods]

Digoxin packs a punch

From the research I've read, it seems to be rarely and inconsistently fatal.

More of a good supporting medication such as in the 3, 4, 5 drug methods.

For anyone interested, on Anna's Archive there are 2022 full versions of the PPH that detail extensively the 3, 4, and 5 drug protocols.

The PPH versions on this site are only the Essentials versions, which typically are missing a lot of info.

 

[SchizoGymnast]

From the research I've read, it seems to be rarely and inconsistently fatal.

More of a good supporting medication such as in the 3, 4, 5 drug methods.

For anyone interested, on Anna's Archive there are 2022 full versions of the PPH that detail extensively the 3, 4, and 5 drug protocols.

The PPH versions on this site are only the Essentials versions, which typically are missing a lot of info.

I'll do some digging of my own and see what I come up with. Ctb with drugs is challenging because there are sooooo many different variables that you can't even see. Plus a lot of these drugs are only available by prescription.

 

[quietwoods]

I'll do some digging of my own and see what I come up with. Ctb with drugs is challenging because there are sooooo many different variables that you can't even see. Plus a lot of these drugs are only available by prescription.

If you're in a western nation, most drugs can be sourced prescription free, besides benzos and opiates, from international online pharmacies.

Planning on sourcing propranolol, meto, ondanestron, and possibly amitriptyline and digoxing (as backups) that way. Just can take a while as these pharmacies have shipment limits.

 

[SomewhatLoved]

OxyContin & Percocet bonus points if you get it from a dealer that cut it with fentanyl

These are both relatively weak opioids considering the indication for use at hand. If we're talking recreational use they fall somewhere in the middle, stronger than codeine or tramadol for sure but there are many stronger ones. For causing respiratory arrest and then death? Ehh I wouldn't wager the potential for surviving with neurological injury, an aspiration event, the embarassment of failing, etc on it...

Really I have a lot of propanalol do they really work

It can work, but in my opinion not the best one you can pick.

Propranolol is a beta blocker. More specifically, a non-selective one so it blocks both the Beta-1 and Beta-2 receptors and their activation effects. Beta-1 effect involves increased inotropy (heart contraction strength), chronotropy (heart rate), and dromotropy (electrical conductivity of heart tissues). So when you block this, your heart beats weaker, at a slower rate, and the tissue becomes less excitable (this is why beta blockers are often used to control arrhythmias). If you take excess your heart will potentially beat so slowly and weakly, that not enough blood is being circulated to perfuse/oxygenate your heart muscle, and then it can become a death spiral from there of less oxygen > worsened heart function > less oxygen > repeat. Beta-1 effect is what's most desirable when CTBing with BBlockers, at least from my understanding. I'm not a doctor though.

Beta-2 effect has various functions, but the most important to discuss for this use case is that Beta-2 activation will cause vasodilation (veins "relaxing"/"opening", dropping blood pressure) and bronchodilation (opening up your lungs, essentially). So, if you block this effect you get vasoconstriction and bronchoconstriction. This is sort of "give and take" for this use, closing up your lungs can cause hypoxia (low oxygen) which is potentially beneficial in more quickly worsening heart function due to hypoperfusion. However, vasoconstriction can potentially help to maintain BP which will act as "compensation" during BBlocker overdose, since heart rate and contractile strength would be dropping so this would somewhat prevent dropping BP. The effect you would see on BP from Beta-2 effect being blocked would probably not be enough to stop the dropping BP from decreased heart function... but in my opinion still probably something you would want to avoid.

Total blood pumped by the heart in one minute is referred to as cardiac output (CO). You can calculate CO by multiplying heart rate (HR) by stroke volume (SV, the amount of blood pushed through the heart with each beat). CO = HR x SV. Since Beta-1 will slow the heart (decreased HR) and decrease contractility (thus lowering SV), you will get overall decreased CO. The body's main way to compensate for shock is by increasing HR, but BBlockers will prevent this. Your body can only increase SV so much but under normal circumstances it can increase HR quite a lot. In emergencies, increasing HR is generally a sign of compensatory shock (the body's stress mechanisms engaging to try and stop you from dying). Obviously there are things like exercise of mental stress that can increase stress, but that is a different conversation. Decreasing SV may be a sign that compensatory mechanisms are failing.

Stroke volume is heavily dependent on preload (the pressure pushing into the heart from blood returning in the veins). Vasoconstriction will aid in maintaining preload. If lots of blood is returning to the heart, it will cause the heart to stretch as it fills. The heart contracts best when slightly stretch, similar to how stretching before a workout will increase performance. If there is not enough blood pushing into the heart, SV will likely drop. This principle is called Starling's Law or the Frank-Starling Law of the Heart. There is much more depth to it but I am not a cardiologist and cannot properly teach it... My point here is that although bronchoconstriction from Beta-2 effect being blocked is likely helpful in the CTB sense, I feel that the vasoconstriction that comes along with it is counterintuitive for the mechanism of this method. Vasoconstriction -> increased venous return -> increased preload -> better maintained SV -> better maintained CO -> better maintained BP -> better oxygenation of heart tissue -> less chance of cardiogenic shock -> less chance of death.

Essentially in my opinion, if you are trying to OD on BBlockers it is best to OD on one that is selective to Beta-1, and does not have Beta-2 effect or at least not as strongly. But yes it can work in high doses.