The potential damage caused by NaNOâ‚‚ is numerous and severe. Severe hypoxia can impair the function of various organs, causing heart damage (which may not be immediately detectable), renal ischemia, brain injury, and, in the most extreme cases, amputation. In some cases, poisoning can lead to a coma, with the possibility of never waking up. Unfortunately, there are no comprehensive statistics as there are for other suicide methods, and often those who suffer catastrophic outcomes do not even have the opportunity to share their experience.