Honestly?
I have tried many drugs.....
Fluoxetine - Didnt do a thing
Cymbalta - Messed me up, don't touch it!!!!
Duloxetine - as above, messed me up!!!
Citalopram - helpe by about 10%. Not good.
Effexor XR - worked fast and brilliantly for about 9 months. The withdrawals are hell but it really helped me at the time. It did make me restless and agitated but as for major depressive disorder and well.. lack of function and feeling like i was permanently at rock bottom, it did lift my mood and gave me more energy. Didn't fix my life but it did something, which was shocking
Trazodone - Same as effexor. It helped about 50%. Didn't stop me being suicidal and attempting suicide but I slept better and functioned a bit better.
5HTP - Nothing
St Johns Wort - Nothing
there are lots more. Honestl i'm trying to think of all of the names and i'm stuck as can't remember them all but i've tried most of the common ones. I'm on Agomelatine right now and again, maybe 15% difference. I'm still going to CTB. I give up on meds helping me get out of this, it simply wont happen now, but I do feel like it's worth trying effexor and trazadone. the SSRI's are not gonna do much, I wouldnt waste time on those TBH. maybe it's different for others but personally.... i dont have faith in SSRI. SNRI's are better, as are tricyclics