There are two types - positive and negative nihilists. Positive nihilists would consider the lack of meaning in life, as a possibility to create their own meaning. While for negative nihilists - there is no point, it's the total lack of motivation to do anything.
It really depends on one important thing, that many don't think much about it - using reason, being rational. Our best advantage over other species is our ability to be rational, to think, use reason. So, in theory, I'm with the positive nihilists, that you can create your own meaning, at least to some extend, by using your own mind, even if it's subjective. For example, many like comics, manga, which are definitely fantasy, but if that makes you happy, why not... For others - music can be a driving force, third - experiencing love (on this planet, we love dogs and cats, since it's generally too difficult to love each other). IMO, you can make the case, that this is possible, and it leaves some room for satisfaction and personal realization.
However, the key point in such idea is that people are reasonable creatures, and the mind can rule their life more then their biological instincts. In reality, most people are not rational, and I doubt they will ever be. It's just some individuals that can achieve some level of rationality. So in practice, I'm negative nihilist... our biological nature is just too strong. If reincarnation exists, I will definitely try to escape on another planet, that is better suited for this "create your own meaning" idea.