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P

pure soul

Student
Jul 17, 2021
131
In my country temperature is max 28 and min 18°c. I m storing my N in my wardrobe. Should I store it in refrigerator or I it is okk that I store it in room temperature???
 
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FromGermany

Specialist
Oct 23, 2021
336
Study of A. T. Still University of Health Sciences, Department of Physiology

Injectable sodium pentobarbital: Stability at room temperature

Abstract
Introduction: Sodium pentobarbital (Nembutal) is a barbiturate used in research as an anesthetic in many animal models. The injectable form of this drug has lately become difficult to procure and prohibitively expensive. Due to this lack of availability, researchers have begun to compound injectable sodium pentobarbital from so-called "nonpharmaceutical" pentobarbital. Some oversight agencies have objected to this practice, claiming a lack of quality control and degradation of the drug. We sought with this study to establish both: 1) a protocol for the preparation of injectable sodium pentobarbital, and 2) standard operating procedures to monitor the quality of the preparation and degradation of the drug over time.

Methods: Our preparation consists of a mixture of sodium pentobarbital in alkaline aqueous solution, propylene glycol, and ethanol. Pentobarbital content in this preparation was assayed by high-pressure liquid chromatography (HPLC). We also assayed pentobarbital content over time in preparations of various ages up to 6 years old.

Results: We determined that the drug degraded at a maximum of 0.5% per year in our preparation (alkaline water/propylene glycol/ethanol) when stored in the dark at room temperature. A yellow discoloration developed after about 2 years, which we have arbitrarily determined disqualifies the preparation from use as an anesthetic. Attempts to spectroscopically assay this discoloration were not successful.
 
intr0verse

intr0verse

Experienced
Jan 29, 2021
297
It depends on how long you intend to keep them. If long term, wrap the bottles in some aluminium foil (or anything that will protect them from the light coming from the refrigerator's light) and place them in the refrigerator if it doesn't raise other people suspicious.
Do not place them in the freezer compartment of your refrigerator; the liquid will froze and the bottles will break.
 
Last edited:
dreadpirateroberts69

dreadpirateroberts69

RRREEEEEEE (she/her)
Nov 4, 2021
278
I have no choice but to keep my N at room temperature as I share a fridge with others, plus there are sections of my fridge that freeze because it's a piece of junk. Because sealed N has such a hefty shelf life my understanding is it should be fine.
 

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