SN, What about Domperidone instead of Metoclopramide?

[Notabadguy]

Will it work? Meto has become difficult to obtain.

 

[autumnal]

SN, What about Domperidone instead of Metoclopramide?

Will it work? Meto has become difficult to obtain.

Yes it should work, as long as it is taken at the required dosage.

This medication is listed as an option in Stan's Guide (note: where he mistypes it as 'Dromperidone') as well as analysed more fully in @Quarky00's SN FAQ, with an extract shown here:

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(REF)​

Domperidone is described there as having a lower risk of extrapyramidal side effects (EPS) when compared to metoclopramide and prochlorperazine.

 

[Notabadguy]

Yes it should work, as long as it is taken at the required dosage.

This medication is listed as an option in Stan's Guide (note: where he mistypes it as 'Dromperidone') as well as analysed more fully in @Quarky00's SN FAQ, with an extract shown here:

View attachment 35584​

(REF)​

Domperidone is described there as having a lower risk of extrapyramidal side effects (EPS) when compared to metoclopramide and prochlorperazine.

I'm currently taking SSRIs antidepressives, which affects serotonin, does it count for anything? I say so because I read that Meto also affects serotonin.
I'm wary about Domperidone because it's true that Stan's guide adivse its use, but not Exit Int, who only advises Meto.

 

[autumnal]

I'm currently taking SSRIs antidepressives, which affects serotonin, does it count for anything? I say so because I read that Meto also affects serotonin.
I'm wary about Domperidone because it's true that Stan's guide adivse its use, but not Exit Int, who only advise Meto.

No, the effect from SSRI's on your serotonin levels is unfortunately not relevant for antiemetic purposes, which require a medication to primarily target the dopamine receptors.

Meto and domperidone are both classed as dopamine antagonists used to treat nauea and vomitting. So they have very similar functions. I would guess that the PPH only mentions the single example of meto because it was written from the perspective of assuming meto was easily obtainable by the readers (generally the elderly or terminally ill with a raft of other conditions and very established doctor-patient relationships), rather than because it disapproved of the other dopamine antagonist antiemetics.