If you haven't tried them, try the following. If you don't have the energy to do your own research, show a hit list to your wife so she can research them for you. You deserve the chance to try new medication that might help you better. Especially after you have both been through so much.
Lithium Carbonate - for suicidal thoughts this is the gold standard. I am currently on 250mg a day. It has quieted my suicidal thoughts and taken away my crying fits and I am just on day 4. I wouldn't say I am happy - until after 8pm when I feel better - but it is early days. It is definitely worth trying for being suicidal. I bought my own online. It is not safe in larger doses without monitoring of your blood levels, but my low dose is safe enough for now. I bought mine online from a reliable source - but I will be seeing a new psychiatrist at the beginning of April for a second opinion. I just can't tolerate my depression for anotehr day - so trying everything to treat it.
Lamictal can really help some people. It has to be titrated very slowly and monitored, as it can cause a fatal rash (which is rare but dangerous) but if it helps you, it can be amazing. I haven't tried that one yet. But there are very good reviews.
MAOIS - they can help when nothing else dose (you cannot combine them with your current medication, so you would need to switch). I have some luck with Selegiline plus DLPA. Moclobemide helped me for a while, but gave me constipation and I don't like it - though I have boxes of the stuff!!!!
Modafinil - in the UK you can buy this online. It can be very helpful for depression. It helps me get out of bed and go to work (and I am bedridden without it). YOu can look up reviews for Modafinil and depression - it has some good reviews.
Low dose Naltrexone - this I haven't tried yet, but I have it. It has some good reviews for depression
Tramadol - 50mg a day. On Drugs.Com it has 82 ten out of ten reviews for treatment resistant depression. I tried it, it only helped me for a day - but other people have more luck. Now I have boxes of the stuff doing nothing!
Tianeptine - this can be bought online. It is prescribed in Europe, though not in USA and UK. It has a different mechanism of action to other anti-ds
Ibuprofen-Coedine - this is a mood brightener. Do not use it every day - it can be addictive. I use it once in a while - though perhaps I should use it once a week. It definitely cheers me up. You can buy this OTC in UK.
Chromium (a supplement) - I have just heard of this. It has some good reviews for depression and could be worth you trying.
Amitryptiline could be worht a shot or other TCAs
There is a website you can order from in UK and Europe which is an online pharmacy and very reliable. It has a ton of Anti-Ds on there - you can look up their side effects and contraindications and test your way through them systematically. There is also a Russian pharma website. Phenibut is very very good for once a week or twice a week relief (it is addictive more than once or twice a week). It also has Etifoxine - which has some great reviews on Reddit. I haven't tried it yet, but I have ordered it. It also has Valdoxan, which can cause liver failure in 0.01 per cent of people, but is a prescription anti-d also called Agomelatine that psychiatrists do prescribe. A psychiatrist did say to me that liver failure is a very low risk with it - and it works in a different way to other Anti-Ds.
I can't share links, but if you have queries, you are welcome to PM me about any of the above or in general.
have you tried MJ - this can also be helpful for anxiety and for depression. It helped me for a while.
Perhaps you owe it to your loving wife to try a few more medications. I am doing this for my family. It sucks mightily, but it is worth a try. I am giving it a year more of enduring suffering.
Also, I have not tried this, but: "Buprenorphine is an opioid medication typically prescribed for treating opioid use disorder. However, literature supports its utility for treatment-resistant depression (1). ..." I have no idea how to source it, but perhaps it is another piece of hope.
I really hope some of this helps you - and I would definitely if I were you have a list of medications to try and work your way thorugh them systematically.
