Help Ondansetron as Antiemetic?

[Ryan.s]

Will Ondansetron work as an antiemetic instead of using meto for the SN method?

-And yes I do realize Ondansetron is not listed in Stan's guide.

 

[Quarky00]

Will Ondansetron work as an antiemetic instead of using meto for the SN method?
-And yes I do realize Ondansetron is not listed in Stan's guide.

This was just recently answered , so I'll just copy paste (for the thousandth time) . In short , TLDR :

others [AEs] may help nausea but are not systematic . This doesn't negate alternatives but it suggests those should be used only as last resort .

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The reasoning for that :

Other AEs?	Don't use – Ondansetron/Zofran Diphenhydramine/Benadryl Dimenhydrinate/Dramamine Serotonin or Histamine only are not as effective. No promotion of gastric emptying Less effective on brain vomiting mechanism for severe poisoning (wide & systematic). D2 receptors go through brainstem and stomach, Histamine do not (History of Drug Discovery for Treatment of Nausea and Vomiting – Figure 5) Effective AE targets both neural & muscular receptors. Read guide ; List of AE by type – dopamine antagonists (Wikipedia)
Why not Ondansetron?	"Metoclopramide is used by Dignitas and i think it's the recommened antiemetic in OD, the second one being domperidone, both dopamine antagonists. Ondansetron (Zofran) is a serotonin receptor antagonist and it's used for cancer patients undergoing chemotherapy because the irritation of the GI mucosa by the medication used in chemotherapy (which is cytotoxic and increase the levels of serotonin in the blood) are transmitted through the vagal nerve to the chemoreceptor trigger zone via activating serotonin receptors (5-HT3). It has no effect on dopamine receptors. "
In simple words?	Need broad systematic AE targeting both CTZ (brain) and stomach plus prokinetic.
How vomiting works	Complex interactions: Chemoreceptor Trigger Zone Vomiting Centre Nucleus Tractus Solitarius GI tract chemoreceptors See graphic schema .

https://sanctioned-suicide.net/thre...-blockers-painkillers-draft.29822/post-634856

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Also advisable to use site search option (see top bar):

https://sanctioned-suicide.net/search/285556/?q=sn+ondansetron&o=relevance

For example (but there are many more):

https://sanctioned-suicide.net/threads/meto-vs-zofran-w-sn.29836/

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Stan mentioned little about it:

Ondansetron, looking at this I could see no detail saying it dealt with the right type of the brain [reaction] for this. If you can [provide info] I would be happy to include it.

 

[Ryan.s]

This was just recently answered , so I'll just copy paste (for the thousandth time) . In short , TLDR :



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The reasoning for that :

Other AEs?	Don't use – Ondansetron/Zofran Diphenhydramine/Benadryl Dimenhydrinate/Dramamine Serotonin or Histamine only are not as effective. No promotion of gastric emptying Less effective on brain vomiting mechanism for severe poisoning (wide & systematic). D2 receptors go through brainstem and stomach, Histamine do not (History of Drug Discovery for Treatment of Nausea and Vomiting – Figure 5) Effective AE targets both neural & muscular receptors. Read guide ; List of AE by type – dopamine antagonists (Wikipedia)
Why not Ondansetron?	"Metoclopramide is used by Dignitas and i think it's the recommened antiemetic in OD, the second one being domperidone, both dopamine antagonists. Ondansetron (Zofran) is a serotonin receptor antagonist and it's used for cancer patients undergoing chemotherapy because the irritation of the GI mucosa by the medication used in chemotherapy (which is cytotoxic and increase the levels of serotonin in the blood) are transmitted through the vagal nerve to the chemoreceptor trigger zone via activating serotonin receptors (5-HT3). It has no effect on dopamine receptors. "
In simple words?	Need broad systematic AE targeting both CTZ (brain) and stomach plus prokinetic.
How vomiting works	Complex interactions: Chemoreceptor Trigger Zone Vomiting Centre Nucleus Tractus Solitarius GI tract chemoreceptors See graphic schema .

https://sanctioned-suicide.net/thre...-blockers-painkillers-draft.29822/post-634856

------------------------------------------------------------------------------------

Also advisable to use site search option (see top bar):

https://sanctioned-suicide.net/search/285556/?q=sn+ondansetron&o=relevance

For example (but there are many more):

https://sanctioned-suicide.net/threads/meto-vs-zofran-w-sn.29836/

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Stan mentioned little about it:

Thank you so much friend. That's exactly what I needed :)

 

[Ryan.s]

This was just recently answered , so I'll just copy paste (for the thousandth time) . In short , TLDR :



------------------------------------------------------------------------------------


The reasoning for that :

Other AEs?	Don't use – Ondansetron/Zofran Diphenhydramine/Benadryl Dimenhydrinate/Dramamine Serotonin or Histamine only are not as effective. No promotion of gastric emptying Less effective on brain vomiting mechanism for severe poisoning (wide & systematic). D2 receptors go through brainstem and stomach, Histamine do not (History of Drug Discovery for Treatment of Nausea and Vomiting – Figure 5) Effective AE targets both neural & muscular receptors. Read guide ; List of AE by type – dopamine antagonists (Wikipedia)
Why not Ondansetron?	"Metoclopramide is used by Dignitas and i think it's the recommened antiemetic in OD, the second one being domperidone, both dopamine antagonists. Ondansetron (Zofran) is a serotonin receptor antagonist and it's used for cancer patients undergoing chemotherapy because the irritation of the GI mucosa by the medication used in chemotherapy (which is cytotoxic and increase the levels of serotonin in the blood) are transmitted through the vagal nerve to the chemoreceptor trigger zone via activating serotonin receptors (5-HT3). It has no effect on dopamine receptors. "
In simple words?	Need broad systematic AE targeting both CTZ (brain) and stomach plus prokinetic.
How vomiting works	Complex interactions: Chemoreceptor Trigger Zone Vomiting Centre Nucleus Tractus Solitarius GI tract chemoreceptors See graphic schema .

https://sanctioned-suicide.net/thre...-blockers-painkillers-draft.29822/post-634856

------------------------------------------------------------------------------------

Also advisable to use site search option (see top bar):

https://sanctioned-suicide.net/search/285556/?q=sn+ondansetron&o=relevance

For example (but there are many more):

https://sanctioned-suicide.net/threads/meto-vs-zofran-w-sn.29836/

------------------------------------------------------------------------------------

Stan mentioned little about it:

Can I PM you bro?