Ondansetron as a replacement for metoclopramide

[AlighieriTTT]

I have been unable to secure metoclopramide to use as an antiemetic to aid in poisoning by SN. However, I have been able to obtain Ondansetron. How effective is Ondansetron compared to metoclopramide, and my real question, should I follow the same schedule for ingestion of Ondansetron as laid out in Stan's guide for metoclopramide assisted SN poisoning? I am worried about overdosing on it beforehand.

 

[eremito]

I believe that PPH guide quoted some medicines only for illustrative purposes. The pharmaceutical market may look somehow differently in my country and some medicines may be substituted, following consultation with a pharmacist. The are marketed under different brand names but may contain the same elements or cause the same body response. Some drugs may be available on prescription, with their substitute products sold over the counter. And so, the same principle may apply to this situation.

 

[AlighieriTTT]

I believe that PPH guide quoted some medicines only for illustrative purposes. The pharmaceutical market may look somehow differently in my country and some medicines may be substituted, following consultation with a pharmacist. The are marketed under different brand names but may contain the same elements or cause the same body response. Some drugs may be available on prescription, with their substitute products sold over the counter. And so, the same principle may apply to this situation.

Yes at first I thought it was branding, but at least in Stan's Guide, ondansetron did not appear in the list of recommended alternative antiemetics (which was all generic names anyways), which fills me with a little bit of worry.

 

[lifeisbutadream]

I have read that ond. is NOT effective for this.

 

[AlighieriTTT]

I have read that ond. is NOT effective for this.

Where have you read that? Based on a Google search it seems that generally, ond is more effective than meto for vomit reduction, which doesn't necessarily translate into more efficacy for a SI attempt, but I am curious who has said that it's not effective.

 

[hapiniuier]

Meto is a strong dopamine and weak serotonin antagonist, ondan is a strong serotonin and no dopamine antagonist. There seems to be a consensus that dopamine inhibition is more important.

On the other hand, there are reports of nausea and puking after met-only protocol, so ideally you'd use both (as recommended by apr. 2022 pph). I don't know how long you've got left, but if I were you I'd keep hunting. I myself am looking for ond to complete the picture so it's a shame we don't know each other - we'd fit like yin and yang.

 

[wait.what]

My understanding is that meto works not only because it prevents vomiting, but also because it speeds gastric emptying. You're not going to vomit up material that has passed beyond your stomach. Ondansetron slows gastric emptying. Apart from the vomiting issue, slowed release of the SN to your small intestine may also affect the absorption of the chemical.