My SN regimen. Please advise.

[can'tdoitanymore]

I have read all the guides so am pretty sure this is all right but just want to double check.

Fast 8 hours with water allowed up to 2 hours before.
1 hour before - 600 mg of ibuprofen
45 mins before - either 3 tablets of Buccastem M under the lip (Prochlorperazine maleate) OR 30mg Domperidone with 8-16mg Zofran
30 mins before - 2mg Xanax and 800mg Tagamet (will not take tagamet if I choose domperidone)
Few mins before - 80mg Propranolol
SN - 25g in 50-100ml of water
Bite of chocolate to remove taste of SN

I haven't decided on the Buccastem M or domperidone yet. My reason for being uncertain about buccastem is because it is the kind that dissolves under the lip. The dose states each pill is 3mg and for a normal dose you should take 1-2 max twice a day but I am unsure if it has different properties to the regular pills. Prochlorperazine maleate vs Prochlorperazine. And I can't find any info on exactly how many to take because the anti-emetic guide dose are for the regular pills you swallow which are normally 10mg. I think attempting to take 30mg so 10 pills of that sounds way too high and could cause EPS and a failed attempt. I have tried one pill and had no reaction. Does anyone know how many Stan took? I believe he used Buccastem M. They also take about an hour to dissolve and multiple could take longer so it's all a bit unknown and confusing compared to the domperidone and zofran.

Am I right that if I choose domperidone I should take no anti-acid or acid-regulator? Or should I take milk of magnesia? I know I cannot take tagamet with it.

I will make extra glasses of SN in case I throw up. I only weigh about 100lbs. Is 25g too high and will cause worse effects? Should I lower to 20g or even 15g?

I have no set date yet just want to be prepared but I do hope it will be soon.

 

[jgm63]

25g is likely too much for your weight. Stan's guide states 20g or 25g for a heavier person.
For your weight, my guess is that 15g SN would be fine, although I'm no expert so that's just my best guess.

3 Buccastem tablets would normally sound a bit on the "light" side, but again, due to your weight being low, that would probably be fine. For domperidone, you might only need 20 mg.

Domperidone is apparently not compatible with H2 blockers such as Tagamet / Zantac. The general opinion seems to be to stick with a basic antacid if using domperidone, eg Rennie, milk of magnesia, etc. Note that antacid is not considered to be essential, so it could be omitted.

Some of the antiemetic notes here may be helpful :

Spoiler: post-509925

https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-509925

 

[can'tdoitanymore]

I guess I'm wondering what does too much really mean? That too much will cause worse side effects and make it more likely to fail? If that is the case are we not risking failure by taking another glass if we throw up seeing as we don't know how much of it will have absorbed and how much is thrown up so could end up drinking more than 25g in total anyway?

That is what I am confused abut with Buccastem 3 tablets (so 9mg) sounds too low compared to the 30mg recommendation of prochlorperazine/meto/domperidone but I can't work out if the Buccastem pills are different to regular Prochlorperazine pills and maybe a lower dose is still equivalent to a higher dose of the regular pills.

Are there any guides that mention how much milk of magnesia or rennie to take?

 

[jgm63]

"Too much" means perhaps more likely to vomit, which is counterproductive.
For your weight, I think 15g would be fine. 20g would be the max for your weight.
I take your point about the quantity being unknown if you end up drinking more.
I don't think you can perfectly analyse every scenario, and dosage in general probably isn't an "exact science", plus Stan did say not to "overthink".

If you read the notes I linked above, you'll see that PPH states the prochlorperazine stat dose is 10 to 20 mg.
So that would be roughly between 4 and 6 Buccastem tablets of 3mg each.
Considering your size, I think 3 tablets would probably be okay, or you could do 4.

Perhaps you could do something like :
take 2 Buccastem tablets, wait 30 mins, take 2 more Buccastem tablets, wait 30 mins, take SN

Prochlorperazine apparently has a higher risk of EPS than Metoclopramide, so you may wish to have Diphenhydramine on standby.

Regarding the quantity of milk of magnesia or rennie, Stan just suggested taking a "double dose" of whatever is stated on the package....
However, if you're going with Buccastem, then you can use Tagamet (again, double dose of whatever is on packet).

If you'd like to double check what the PPH says, then :

Spoiler: pph-dec-2019

https://sanctioned-suicide.net/threads/pph-dec-2019.30370/

Note : As always, please note that I strongly encourage you to seek help with whatever is troubling you. With the right help things can improve. There are many sources of help if you look and reach out. Please seek assistance in any and every way possible. You alone must decide upon your actions and take full responsibility for them, and you should always favour seeking help and keeping out of harm's way.

 

[Quarky00]

Sounds good , except more Buccastem and 20g SN enough , as mentioned

My schedule is Xanax 20m before, because it impairs me within 15m (I'll prepare SN before). But each to their metabolism :)

Domperidone is apparently not compatible with H2 blockers such as Tagamet / Zantac.

I wonder if there are any references for that. It appears Domperidone okay before antacid as it has enough time to metabolize. Domperidone may be less effective if taken at the same time , but okay if taken before (from leaflet):

 

[jgm63]

Good observation.
Stan's guide has the antiemetic before the H2 blocker/antacid, so that should be fine if you follow the guide.

Considering the OP is only 100 pounds, I would think 9mg of Buccastem would be okay, but I guess 12mg to be safe would be okay also....

 

[can'tdoitanymore]

I wonder how long is considered to be not taking them simultaneously though.
I think I'll change the xanas to 15 to 20 mins before as well actually. It hits me quite fast.

Sounds good , except more Buccastem and 20g SN enough , as mentioned

My schedule is Xanax 20m before, because it impairs me within 15m (I'll prepare SN before). But each to their metabolism :)



I wonder if there are any references for that. It appears Domperidone okay before antacid as it has enough time to metabolize. Domperidone may be less effective if taken at the same time , but okay if taken before (from leaflet):

View attachment 25516

"Too much" means perhaps more likely to vomit, which is counterproductive.
For your weight, I think 15g would be fine. 20g would be the max for your weight.
I take your point about the quantity being unknown if you end up drinking more.
I don't think you can perfectly analyse every scenario, and dosage in general probably isn't an "exact science", plus Stan did say not to "overthink".

If you read the notes I linked above, you'll see that PPH states the prochlorperazine stat dose is 10 to 20 mg.
So that would be roughly between 4 and 6 Buccastem tablets of 3mg each.
Considering your size, I think 3 tablets would probably be okay, or you could do 4.

Perhaps you could do something like :
take 2 Buccastem tablets, wait 30 mins, take 2 more Buccastem tablets, wait 30 mins, take SN

Prochlorperazine apparently has a higher risk of EPS than Metoclopramide, so you may wish to have Diphenhydramine on standby.

Regarding the quantity of milk of magnesia or rennie, Stan just suggesting taking a "double dose" of whatever is stated on the package....
However, if you're going with Buccastem, then you can use Tagamet (again, double dose of whatever is on packet).

If you'd like to double check what the PPH says, then :

Spoiler: pph-dec-2019

https://sanctioned-suicide.net/threads/pph-dec-2019.30370/

Note : As always, please note that I strongly encourage you to seek help with whatever is troubling you. With the right help things can improve. There are many sources of help if you look and reach out. Please seek assistance in any and every way possible. You alone must decide upon your actions and take full responsibility for them, and you should always favour seeking help and keeping out of harm's way.

Oh ok thanks. 4 sounds a lot more reasonable than 10.
Only problem with these pills is that they cannot be swallowed, you have to wait for them to dissolve which the leaflet say can take between 1-2hours. My trial with one pill took an hour so I can't space them out.

 

[jgm63]

I wonder how long is considered to be not taking them simultaneously though.
I think I'll change the xanas to 15 to 20 mins before as well actually. It hits me quite fast.




Oh ok thanks. 4 sounds a lot more reasonable than 10.
Only problem with these pills is that they cannot be swallowed, you have to wait for them to dissolve which the leaflet say can take between 1-2hours. My trial with one pill took an hour so I can't space them out.

ok, well then I suppose you could just take 3 or 4 of them in one go. As mentioned, it may be a good idea to have diphenhydramine on standby (see notes below).
If you're going with the Buccastem then you don't need to worry about any antacid/H2 blocker interaction.

If you're going with Domperidone, then I would make a guess and say wait 30 minutes before taking antacid, or you could omit the antacid since it's not essential, or you could do a "single dose" rather than the "double dose" that Stan states.

DIPHENHYDRAMINE NOTES
50 mg of diphenhydramine can be used to treat EPS symptoms that some people get from taking anti-emetics. EPS are not very common, but could be quite disturbing if you do get them, so some people may wish to have diphenhydramine on standby. EPS risk may be increased if using prochlorperazine instead of metoclopramide. Diphenhydramine may be available as Benadryl, or Nytol, or simply as Diphenhydramine, or perhaps as some other product, depending on country. You should be able to find these over-the-counter or online. Look for something with "diphenhydramine" on the label, eg google for "benadryl diphenhydramine" or "nytol diphenhydramine". Some variants of those products don't contain diphenhydramine, so check.

 

[can'tdoitanymore]

If you do have to take diphenhydramine does that mean the whole attempt has to be aborted or does it not interact with the SN?

 

[jgm63]

If you do have to take diphenhydramine does that mean the whole attempt has to be aborted or does it not interact with the SN?

I would assume you could continue with the attempt, although I'm not an expert, so I can't say for certain.
Diphenhydramine apparently does have some antiemetic properties itself.

 

[SugarbushMtn]

EPS symptons are very, very rare.
That is a lot of meds in one hour. The risk is vomiting. More meds in a short period of time will increase this risk. You could move the ibuprofen out to 2-3 hours prior and it will have the same effect.

 

[jgm63]

EPS symptons are very, very rare.

I'm not so sure that they're quite as rare as some people say. I've seen a few posts here and there on this site where people have had them, in varying degrees (and a couple of cases discussed in the chat area). Also, the risk is apparently increased if using prochlorperazine instead of metoclopramide.

Perhaps the severe cases are pretty rare, but anyhow, many people just want to cover as many bases as possible, to keep their minds at rest, so having some diphenhydramine on standby can help people to feel fully prepared.

 

[Quarky00]

You could move the ibuprofen out to 2-3 hours prior and it will have the same effect.

That's a good point :) Anyone knows why we are taking painkillers so close to zero hour?
I think it's a PPH practice never really discussed

Also, if I recall, some NSAIDs irritate GI tract

 

[jgm63]

EPS symptons are very, very rare.
That is a lot of meds in one hour. The risk is vomiting. More meds in a short period of time will increase this risk. You could move the ibuprofen out to 2-3 hours prior and it will have the same effect.

Keep in mind, the diphenhydramine would only be taken in the event of EPS, so hopefully won't be taken....

 

[Jean4]

25g is likely too much for your weight. Stan's guide states 20g or 25g for a heavier person.
For your weight, my guess is that 15g SN would be fine, although I'm no expert so that's just my best guess.

3 Buccastem tablets would normally sound a bit on the "light" side, but again, due to your weight being low, that would probably be fine. For domperidone, you might only need 20 mg.

Domperidone is apparently not compatible with H2 blockers such as Tagamet / Zantac. The general opinion seems to be to stick with a basic antacid if using domperidone, eg Rennie, milk of magnesia, etc. Note that antacid is not considered to be essential, so it could be omitted.

Some of the antiemetic notes here may be helpful :

Spoiler: post-509925

https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-509925

You said the magic name? Who I am missing today.... and you have now given me the excuse to post! Thank you! ;)

https://sanctioned-suicide.net/threads/stans-guide-to-sn.27535/

 

[jgm63]

@can'tdoitanymore
This is an excellent omen. @Jean4 has graced your thread with her presence.

 

[jgm63]

N.B. I did a little "buccastem write up" :

Spoiler: buccastem notes

https://sanctioned-suicide.net/threads/n-protocol-regime-regimen-notes.27092/post-568550