Meto fucked me up.

[Mofreeko]

Ok, so last month I decided it was finally time to take my meto/Ondansetron 48 hour regime. I decided on this one from wiki books:

Wiki author best option

Take 15 mg Metoclopramide every 8 hours, i.e. 3 times per day, starting 48 hours in advance.

Take the last dose Metoclopramide 45-60 min prior to cocktail ingestion along with 8-16 mg Ondansetron.

A few hours after taking the meto I noticed two symptoms:
1 - inability to sit still. I could not sit down or stand in one place which lead to me randomly pacing around my apartment for hours.
2 - my tongue and jaw seemed to have a mind of their own. My lower jaw kept wanting to go to the side and my tongue wanted to flex as hard as it could and stick out of my mouth.
Eventually my tongue started going up into the roof of my mouth and kinda of block off my breathing. I panicked and called 911 and explained what I had taken. Everyone from the 911 call person to paramedics and nurses/doctors chalked it up to an allergic reaction. I was skeptical but they gave me and epi pen and then pumped me full of benadryl. When they did that the symptoms completely stopped for a few hours, after which they came back and they would pump me with more benadryl and the symptoms would go away again. I was there for 12 hours until the symptoms stopped coming back. Thankfully meto is also a drug for gerd so when they asked me why I took it I just told them that. I'm still skeptical that it was an allergic reaction but the benadryl worked so... maybe? The doctors and nurses seemed to think so.

The whole experience freaked me out to the point that I just was sure that I didn't want to die any more and completely abandoned this website. Well now that I've calmed down I still want to die, but now I'm really worried about something going wrong and winding up in the hospital again. Meto is obviously out for me so what alternatives are there? Every source says meto is key, so what am I supposed to do?

 

[not_a_robot]

Ok, so last month I decided it was finally time to take my meto/Ondansetron 48 hour regime. I decided on this one from wiki books:

Wiki author best option

Take 15 mg Metoclopramide every 8 hours, i.e. 3 times per day, starting 48 hours in advance.

Take the last dose Metoclopramide 45-60 min prior to cocktail ingestion along with 8-16 mg Ondansetron.

A few hours after taking the meto I noticed two symptoms:
1 - inability to sit still. I could not sit down or stand in one place which lead to me randomly pacing around my apartment for hours.
2 - my tongue and jaw seemed to have a mind of their own. My lower jaw kept wanting to go to the side and my tongue wanted to flex as hard as it could and stick out of my mouth.
Eventually my tongue started going up into the roof of my mouth and kinda of block off my breathing. I panicked and called 911 and explained what I had taken. Everyone from the 911 call person to paramedics and nurses/doctors chalked it up to an allergic reaction. I was skeptical but they gave me and epi pen and then pumped me full of benadryl. When they did that the symptoms completely stopped for a few hours, after which they came back and they would pump me with more benadryl and the symptoms would go away again. I was there for 12 hours until the symptoms stopped coming back. Thankfully meto is also a drug for gerd so when they asked me why I took it I just told them that. I'm still skeptical that it was an allergic reaction but the benadryl worked so... maybe? The doctors and nurses seemed to think so.

The whole experience freaked me out to the point that I just was sure that I didn't want to die any more and completely abandoned this website. Well now that I've calmed down I still want to die, but now I'm really worried about something going wrong and winding up in the hospital again. Meto is obviously out for me so what alternatives are there? Every source says meto is key, so what am I supposed to do?

Do you take any meds regularly?
Any other known allergies?
It was an anaphylactic reaction.

 

[Mofreeko]

Do you take any meds regularly?
Any other known allergies?
It was an anaphylactic reaction.

I take zero meds. No other known allergies.

 

[jake3d]

Meto has this effect on some people, and yes, Benadryl is what you should take to counteract these symptoms. I have taken meto and got no side effects apart from a little drowsiness, but some people are really sensitive to it. Chances for the effects you experienced are 1 in 500. Not exactly unheard off, but also not terribly common.

Domperidone can be used instead of meto, it has a similar mechanism of action but it does not cross the blood-brain barrier thus the chances of side effects are slim to none.

 

[alfie]

Meto has this effect on some people, and yes, Benadryl is what you should take to counteract these symptoms. I have taken meto and got no side effects apart from a little drowsiness, but some people are really sensitive to it. Chances for the effects you experienced are 1 in 500. Not exactly unheard off, but also not terribly common.

Domperidone can be used instead of meto, it has a similar mechanism of action but it does not cross the blood-brain barrier thus the chances of side effects are slim to none.

Why is meto much more frequently recommended over domperidone?

 

[jake3d]

Likely because it is an older drug and it has been studied more, and because Dignitas uses it.

 

[alfie]

Oh, I see... Thanks...

 

[Solo]

I once took 60 mg with alchahol which worsen the side effects shit was rough for like a full day.im glad I slept through most of it. starting to wonder if meto actually prevents vomiting or just fucks you up. the 30 mg stat dose should be easy when the time comes

 

[jake3d]

starting to wonder if meto actually prevents vomiting or just fucks you up.

There is very little that can prevent vomiting when you've drunk a shitload of alcohol. Other poisons are actually easier to keep down since you have to use a smaller quantity.

 

[Solo]

Good to know but I only plan on using N with the meto but I genuinely felt vomitish after taking the meto lol it's supposed to prevent vommiting.the only way I can tell if it works is when I already drank the poison I guess but it's already proven it works so I got no doubts

 

[Roger]

Extrapyramidal symptoms - not rare with metoclopramide.

 

[jake3d]

Extrapyramidal symptoms - not rare with metoclopramide.

1 in 500 counts as "very rare" in medical speak. This data is taken straight from the medicine leaflet.

 

[Roger]

1 in 500 counts as "very rare" in medical speak. This data is taken straight from the medicine leaflet.

Leaflet in my Actavis Metoclopramide package shows uncontrollable movements/muscle contracture etc. as "Common. May affect up to 1 in 10 people."

At the other end is "Rare. May affect 1 in 1000 people."

 

[jake3d]

Interesting, mine's from a different manufacturer and shows different numbers!

 

[Roger]

Date of last revision of my leaflet - May 2015.

What about yours ?

 

[Brainpain]

Isn't there an option to take a large dose at once ?

 

[Roger]

whilst on the subject - the latest revision of the PPeH and several preceding all advise a single stat dose. No mention of a 48 hour regimen.
The wozz Guide to a Humane Death says that a regimen of at leas 36 hours is "very important."

Intuitively, to me at least, the regimen sees to be a better bet to gradually build up a level in the body.
However, I personally feel that I will only be able to go in response to a sudden impulsive moment of crisis. Trying to maintain determination over 48 hours has been extremely difficult

Isn't there an option to take a large dose at once ?

Yes - the stat dose. But our answers crossed in the ether, see my post #17

 

[Jolene40]

Is cyclizine an option. I have a few of these and have no strength to get anything else

 

[jake3d]

Cyclizine does not block dopamine receptors at all, it can at most be used alongside another anti-emetic such as domperidone. You cannot use it on its own for any poisoning method if you wish it to be reliable.

 

[Jolene40]

Cyclizine does not block dopamine receptors at all, it can at most be used alongside another anti-emetic such as domperidone. You cannot use it on its own for any poisoning method if you wish it to be reliable.

Ok thankyou

 

[LaBrava]

So should I consider buying some benadryl in preparation for testing out meto? It seems to be available OTC at chemists in the UK? Is that the right stuff?

 

[jake3d]

Yes, Benadryl (Dyphenhydramine) is OTC almost everywhere.

 

[LaBrava]

Thanks.

 

[Brainpain]

I have 6 15mg tablets. Is that enough?

 

[jake3d]

I have 6 15mg tablets. Is that enough?

Talking of meto? Yes, that will be enough. It's usually in 10mg pills with recommended dosage 30mg max/24 hours. Since you have 15mg ones, take them every 12 hours for 2 days and you will have 2 left.

Up to you if you take another one or both of these 1 hour before your N. If you don't get any scary side effects in the 2 days prior, not much wrong will happen if you take both.

 

[Brainpain]

Talking of meto? Yes, that will be enough. It's usually in 10mg pills with recommended dosage 30mg max/24 hours. Since you have 15mg ones, take them every 12 hours for 2 days and you will have 2 left.

Up to you if you take another one or both of these 1 hour before your N. If you don't get any scary side effects in the 2 days prior, not much wrong will happen if you take both.

Thanks! I think I should be good. I've taken it before when I've had nausea from pain medication.

 

[littlelady774]

This is why I'm gonna take domperidone instead... If I get side effects, my parents are gonna find out and ask why I took meto and how I got it. They'll be watching me like a hawk and be very suspicious.
Hope domperidone works just the same.

 

[lululoo]

Intuitively, to me at least, the regimen sees to be a better bet to gradually build up a level in the body.
However, I personally feel that I will only be able to go in response to a sudden impulsive moment of crisis. Trying to maintain determination over 48 hours has been extremely difficult

Roger, I concur. The regimen also sounded better to me. But after starting it and having to abort, I realize I will have to go with stat does. I just don't have the emotional strength for that kind of build up. It was destroying my mind. I'm not sure when I will do it, but my mind is more at ease not having to anticipate the 48 hour regimen. I only have to worry about one hour.

Also just want to report that I had 0 meto side effects. So not everyone has problems with it. (though I guess I could still have problems at the higher stat dose. but as long as I can still make use of my limbs, who cares...)

 

[jake3d]

Also just want to report that I had 0 meto side effects. So not everyone has problems with it. (though I guess I could still have problems at the higher stat dose. but as long as I can still make use of my limbs, who cares...)

I only got some drowsiness from 20mg of meto and i have some EPS of my own since my injury and mistreatment, mostly in my fingers. Meto didn't make it any worse.

 

[khw777]

Ok, so last month I decided it was finally time to take my meto/Ondansetron 48 hour regime. I decided on this one from wiki books:

Wiki author best option

Take 15 mg Metoclopramide every 8 hours, i.e. 3 times per day, starting 48 hours in advance.

Take the last dose Metoclopramide 45-60 min prior to cocktail ingestion along with 8-16 mg Ondansetron.

A few hours after taking the meto I noticed two symptoms:

1 - inability to sit still. I could not sit down or stand in one place which lead to me randomly pacing around my apartment for hours.
2 - my tongue and jaw seemed to have a mind of their own. My lower jaw kept wanting to go to the side and my tongue wanted to flex as hard as it could and stick out of my mouth.
Eventually my tongue started going up into the roof of my mouth and kinda of block off my breathing. I panicked and called 911 and explained what I had taken. Everyone from the 911 call person to paramedics and nurses/doctors chalked it up to an allergic reaction. I was skeptical but they gave me and epi pen and then pumped me full of benadryl. When they did that the symptoms completely stopped for a few hours, after which they came back and they would pump me with more benadryl and the symptoms would go away again. I was there for 12 hours until the symptoms stopped coming back. Thankfully meto is also a drug for gerd so when they asked me why I took it I just told them that. I'm still skeptical that it was an allergic reaction but the benadryl worked so... maybe? The doctors and nurses seemed to think so.

The whole experience freaked me out to the point that I just was sure that I didn't want to die any more and completely abandoned this website. Well now that I've calmed down I still want to die, but now I'm really worried about something going wrong and winding up in the hospital again. Meto is obviously out for me so what alternatives are there? Every source says meto is key, so what am I supposed to do?

Sounds like you had tardive dyskinesia symptoms.