Meto and Psychotropic Meds

[Theon]

Plan was to cbt in four weeks after a last trip back home for mom's birthday and before I'm supposed to start a job I don't think I can do because of my condition. I ordered SN and meto: Check. Ordered N: Check. I was going to take the N unless it doesn't come in time, then I would switch to SN. I thought I'd done all the research. And then I started learning more about meto and I think I'm screwed. I take Seroquel which the PPH says has a bad interaction with meto. I thought, ok, I'll just stop it a week or so before. Then I read about interactions between Effexor and meto. Also bad. And now my shrink just prescribed Wellbutrin. Also bad. I guess I can stop everything and not take the Wellbutrin but a part of me has a slight, slight hope that the Wellbutrin will help me. But it's doubtful. I'm at a loss. What awaits me right now is very, very bad. What awaits me if I have an adverse reaction to the meto is horrifying. Has anyone who takes/has taken psychotropic drugs had any experience taking meto? I'm looking for some/any hope I can still cbt this way.

 

[Soul]

Domperidon is less risky than meto. I'd order that.

 

[kuddelmuddel23]

In your case I would rather leave meto out of the question and switch to Domperidone and Ondansetron.

Either the 48 hours regimen with 10mg Domperidone every 8 hours and one hour before taking N/SN additionally 8-16mg Ondansetron. Or stat dose with 20-30mg Domperidone and 8-16mg Ondansetron one hour before taking N/SN.

 

[Theon]

but they're not supposed to work as well right?

 

[kuddelmuddel23]

With the additional Ondansetron Domperidone comes close to Meto. Of course it is not the same and a bit weaker, but it will be enough. In any case better than risking it with meto.

 

[Soul]

but they're not supposed to work as well right?

That's one theory, but I've seen people say there's no real difference in their effectiveness as anti-emetics. Perhaps taking domperidon for the 48-hour regimen and meto as the stat dose would work for you.

What's ondonsetron, please and thank you?

 

[kuddelmuddel23]

What's ondonsetron, please and thank you?

So Meto has summarized three features: D2 and 5-HT3 antagonism, and 5-HT4 agonism.

If you now replace Meto with Domperidone, you lose the mode of action of the 5-HT3 antagonism and the 5-HT4 agonism. And there comes Odansetron into play, it is also an anti emetic and a 5-HT3 antagonist.So you would only loose the 5-HT4 agonism in regards to meto. The 5-TH4 agonist accelerates gastric emptying and is not 100% needed for either of these methods, but can help with the faster absorption of the drug.

 

[Soul]

So Meto has summarized three features: D2 and 5-HT3 antagonism, and 5-HT4 agonism.

If you now replace Meto with Domperidone, you lose the mode of action of the 5-HT3 antagonism and the 5-HT4 agonism. And there comes Odansetron into play, it is also an anti emetic and a 5-HT3 antagonist.So you would only loose the 5-HT4 agonism in regards to meto. The 5-TH4 agonist accelerates gastric emptying and is not 100% needed for either of these methods, but can help with the faster absorption of the drug.

Arrrgh
Thank you so much but my eyes glaze over when I see pharmaceutical details. I just meant "is it another prescription buddy or OTC? Does it have other names? Where can we get it?"

 

[Theon]

They're both prescription. One isn't even available in the US. And neither is "guaranteed" the way meto seems to be.

 

[kuddelmuddel23]

Arrrgh
Thank you so much but my eyes glaze over when I see pharmaceutical details. I just meant "is it another prescription buddy or OTC? Does it have other names? Where can we get it?"

Oh sorry. It is a prescription-only drug, known as Zofran or Ondisolv.

 

[Soul]

Oh sorry. It is a prescription-only drug, known as Zofran or Ondisolv.

Thank you! <3

 

[dolphin]

Hi guys, I took a low dose of wellbutrin for the past week. I'm stopping it today. I'm taking the meto next week and hoping there will be no issues. What i've read online says that wellbutrin can increase plasma concentration of meto and increase risk of EPS .. im hoping this stuff is out of my body. Really anxious about this.