I have experience with them. I want to start using them again for depression because I found them helpful, but the only thing stopping me right now is they're pretty expensive.
Psilocybin is pretty similar to SSRIs. When I used psilocybin, I took a low-medium intensity trip every couple months. I didn't microdose. My experience is that it really helped with depression and anxiety, it made me feel at peace with the world in ways that were much more effective compared to SSRIs. However, there were nasty side effects that would pop up after a couple days including derealization and vision changes. Shrooms will give you visuals when you are using them at higher doses (think mandalas and other geometric patterns) but those effects can persist for a long time after use (look up Hallucinogen persisting perception disorder / HPPD). For me they lasted a couple months after completely stopping, but apparently they can be permanent.
SSRIs were not as effective for my mental health. They reduced my depression, but they did nothing for my anxiety and just made me feel numb. Shrooms made me feel happy and one with myself, and detached in a way that made me unbothered by the bad things in life. SSRIs just made me feel like I was sitting in the passenger's seat and didn't have agency if that makes sense, maybe since I was detached from feeling anything. The only "positive" I had from SSRIs is that I didn't experience nearly the amount of negatives compared to shrooms, for example SSRIs didn't affect my vision or made me feel derealized like shrooms did. Other people can still get really nasty side effects from SSRIs anyways, and honestly I'm not convinced that they're "safer", it's just a different risk.