Is ODing on Nortriptyline a reliable way to go? If so, how much would be needed?

[wildflowercloud]

Heya guys

We're in a weird space. Completely set on CTB, just struggling to be set on a method.

Would Nortriptyline be a reliable medication to OD on? If it would be, how much would be needed?
If it helps, we are 168cm tall and weigh around 87kg.

Thank you!

 

[Darkover]

The oral LD50 of nortriptyline in the rat is 405 mg/kg.
LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group.

you need 35grams

 

[wildflowercloud]

The oral LD50 of nortriptyline in the rat is 405 mg/kg.
LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group.

you need 35grams

Fuck that's a lot. Don't know how it would take to stockpile that much with 25mg tablets.
Thank you for this!

 

[intr0verse]

Same as amitriptyline, 10 or more grams. Read the PPeH, amitriptyline section.

 

[Dmoore3232]

I am wondering if amitriptyline is the way to go. I don't know where to get 35 grams though. Pills are the way to go.

 

[wildflowercloud]

Same as amitriptyline, 10 or more grams. Read the PPeH, amitriptyline section.

Thank you!

I am wondering if amitriptyline is the way to go. I don't know where to get 35 grams though. Pills are the way to go.

Yeah same, don't know how to get that much either. I hope you find what you're looking for and it goes as smoothly and okay as possible!

 

[nicotine_goblin]

Nortriptyline is a tricyclic antidepressant, here's an excerpt from wikipedia on interactions with this type: The TCAs are highly metabolised by the cytochrome P450 (CYP) hepatic enzymes. Drugs that inhibit cytochrome P450 (for example cimetidine, methylphenidate, fluoxetine, antipsychotics, and calcium channel blockers) may produce decreases in the TCAs' metabolism, leading to increases in their blood concentrations and accompanying toxicity.[30]​ Drugs that prolong the QT interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, and some antipsychotics may increase the chance of ventricular dysrhythmias. TCAs may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. Side effects may also be enhanced by other drugs that have antimuscarinic properties.
It may help to use a combination of drugs if you want a lethal overdose

 

[wildflowercloud]

Nortriptyline is a tricyclic antidepressant, here's an excerpt from wikipedia on interactions with this type: The TCAs are highly metabolised by the cytochrome P450 (CYP) hepatic enzymes. Drugs that inhibit cytochrome P450 (for example cimetidine, methylphenidate, fluoxetine, antipsychotics, and calcium channel blockers) may produce decreases in the TCAs' metabolism, leading to increases in their blood concentrations and accompanying toxicity.[30]​ Drugs that prolong the QT interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, and some antipsychotics may increase the chance of ventricular dysrhythmias. TCAs may enhance the response to alcohol and the effects of barbiturates and other CNS depressants. Side effects may also be enhanced by other drugs that have antimuscarinic properties.
It may help to use a combination of drugs if you want a lethal overdose

Thank you heaps for looking for this!!