If painkiller ODs won't work, how have people died from them?

[Walilamdzi]

I was always warned about this growing up, I'm still shocked if it doesn't work at all. It is so much easier to swallow a pill than to do something with a physical setup.

 

[disconnection]

Oh it does work sometimes. It's just hellishly unreliable. Like you can take an enormous paracetamol overdose and still recover after a couple of weeks of agony or you might take just over a fatal dose and die after a few days. Still in agony.

 

[Walilamdzi]

Oh it does work sometimes. It's just hellishly unreliable. Like you can take an enormous paracetamol overdose and still recover after a couple of weeks of agony or you might take just over a fatal dose and die after a few days. Still in agony.

I have about 75 x 500mg tablets... well zapain tablets so also contain codeine but surely that would be enough?

The only other medications I have are quite a lot of quetiapine and also carbamazepine but those wouldn't do much. Although I wonder if I took all the zapain and all the quetiapine if the quetiapine would sedate me to the extent of not being aware of the other effects.

Paracetamol poisonings have jumped 44% in 10 years. We must change how it's sold | Rose Cairns for the Conversation

It’s the No 1 pharmaceutical Australian poisons centres receive calls about

www.theguardian.com

 

[disconnection]

Who can say? The wiki page reckons 0.1% of people who OD die and 100,000 people a year OD in the US. However I think most people seek help shortly after ODing cause panic sets in. I don't mind adding that I took about that amount once and after 8 hours I went and got help. After about that time its no longer reversible.

 

[Aliali1992]

You have at least a 95% chance of failing...plus paracetamol mechanism is liver faliure which means weeks of strong pain and vomiting. Not fun at all

 

[Aap]

No. You likely will develop liver failure from the Tylenol if taken Without medical intervention. Codeine is a very weak opiate that must be converted (demethylated) by the liver to morphine to be effective. There is a dosage ceiling around 180 mg; after this the cyp450 enzymes will become saturated. The amount of paracetamol will likely decrease the conversion further.

 

[SleepyTime]

If you are going to attempt with any drug mixed with acetaminophen/paracetamol (APAP) you should do a search on how to do a Cold Water Extraction. It is very simple and will remove the bad toxic substance (APAP) and leave you with only the good toxic substance. In the event of a failure to CTB you won't be left with the liver damage from a large dose of APAP.

 

[Aap]

Let me say again, It would be very, very difficult to reliably do what you are suggesting with codeine only due to,what I wrote above.

 

[Living sucks]

@Walilamdzi you are posting a lot of what if questions recently.., many different methods. Have you not settled on a method after being a user so long?

 

[SleepyTime]

Let me say again, It would be very, very difficult to reliably do what you are suggesting with codeine only due to,what I wrote above.

I agree. I forgot to mention that in my mind any discussion of opioids always includes the co-ingestion of benzos and/or alcohol which increases the likelihood of death. But I am usually coming at this from the low lethal OD from benzos versus the much higher lethal OD when benzos are combined with opioids.

 

[Aap]

Not saying it isn't possible, but codeine is not the way to go. It is essentially a prodrug with a ceiling that is high but not that high.

 

[Walilamdzi]

@Walilamdzi you are posting a lot of what if questions recently.., many different methods. Have you not settled on a method after being a user so long?

I have been trying partial hanging but it's very difficult, so I was hoping some of the medications I have to hand could combine or work in OD.

 

[Meowkin]

I have been trying partial hanging but it's very difficult, so I was hoping some of the medications I have to hand could combine or work in OD.

It can be difficult getting the right method especially if you have limited access to the more effective ones. I tried partial hanging a few times too back when I didn't have many options. I got close once but then my survival instinct kicked in and I ended up untying the scarf from around my neck. I do believe you need a certain amount of luck to ctb whether it's planned or on impulse. I wish you lots of luck whatever you decide.

 

[Walilamdzi]

It can be difficult getting the right method especially if you have limited access to the more effective ones. I tried partial hanging a few times too back when I didn't have many options. I got close once but then my survival instinct kicked in and I ended up untying the scarf from around my neck. I do believe you need a certain amount of luck to ctb whether it's planned or on impulse. I wish you lots of luck whatever you decide.

Yeah I'm not sure why people think I'm not legitimately seeking something that works, I'm just struggling so much and don't feel confident in partial but it seems the only thing other than an overdose that wouldn't work.

 

[Soul]

I've read so much here about people's struggles to get partial suspension to work that I've decided to go straight to full suspension as my plan B.

Sending well-wishes, @Walilamdzi x

 

[Walilamdzi]

I've read so much here about people's struggles to get partial suspension to work that I've decided to go straight to full suspension as my plan B.

Sending well-wishes, @Walilamdzi x

Hey, what's your main plan?

Thanks, finding everything really hard at the moment. You too x

 

[Soul]

@Walilamdzi my dear, my main plan is in flux right now, as I keep hearing about contraindications I hadn't originally considered for the debreather and for SN. Long drop is something I'd never thought would suit me, but it is pretty reliable.

 

[Schweppes]

I've done a few painkiller ODs, I took in excess of 32 with alcohol. Didnt work just gave me really bad liver pain

 

[BaronVon]

I have about 75 x 500mg tablets... well zapain tablets so also contain codeine but surely that would be enough?

The only other medications I have are quite a lot of quetiapine and also carbamazepine but those wouldn't do much. Although I wonder if I took all the zapain and all the quetiapine if the quetiapine would sedate me to the extent of not being aware of the other effects.

Paracetamol poisonings have jumped 44% in 10 years. We must change how it's sold | Rose Cairns for the Conversation

It’s the No 1 pharmaceutical Australian poisons centres receive calls about

www.theguardian.com

I took around 140 Paracetamol plus some additional tabs and alcohol etc and did not work , was not far away though the hospital doctor informed me .. trust me this is not a good method to try

 

[Walilamdzi]

I took around 140 Paracetamol plus some additional tabs and alcohol etc and did not work , was not far away though the hospital doctor informed me .. trust me this is not a good method to try

What mg of paracetamol? 140 x 500mg? That's pretty surprising, did you phone emergency services afterwards?

 

[SleeplessSoul]

I have googled toxic levels in the past and worked out how many I'd have to take for it to be a fatal dose would be based on my weight and I've been close before but the side effects of the OD has always been too much and I've called for help or a friend has

I took around 140 Paracetamol plus some additional tabs and alcohol etc and did not work , was not far away though the hospital doctor informed me .. trust me this is not a good method to try

Damn! I took 64 once and I thought that was bad! It depends on how much you weigh though I guess? How did you feel? I couldn't stop vomiting it was awful.

Yeah I'm not sure why people think I'm not legitimately seeking something that works, I'm just struggling so much and don't feel confident in partial but it seems the only thing other than an overdose that wouldn't work.

I'm so sorry. I wish I could do something or say something to help you

 

[BaronVon]

What mg of paracetamol? 140 x 500mg? That's pretty surprising, did you phone emergency services afterwards?

Approx 12 hours of violent vomiting and pain , eventually gave in and called ambulance, stomach pumped and drip for a while and hospital for a week, doctor said maybe approx 1-2 hours from death . i was young then , think thats what helped . was not a good experience , much better and more peaceful methods .

 

[schopenh]

This is just semantics. Painkillers are not one class of drugs, there are many types. Paracetamol, NSAIDs and meds which are a combination of a very low dose opioid w/ one of the former (eg. Tylenol-3) even in very large amounts are unlikely to kill and very likely to cause painful liver damage. On the other hand, high dose opioids/opiates taken in a lethal amount have a good chance of killing a person, especially if potentiated with drugs like benzos.

 

[MissKatrina]

I was always warned about this growing up, I'm still shocked if it doesn't work at all. It is so much easier to swallow a pill than to do something with a physical setup.

There's a bias.They only ever highlight the number of people that died from an overdose. They don't often count the number of people that survived both in terms of hospital and non hospital trips.

Plus painkillers aren't designed to kill you. That's just a result of not being able to be metabolized/ excreted (paracetamol- lived failure) or a side effect of the drug (opioids- respiratory depression). But most OTC stuff is slow and painful to OD on- done on purpose for public safety. You have to be a little creative if you want to CTB with meds with low discomfort.

 

[Aap]

There seems to some conflating of the term "painkiller," and its being used to refer to Tylenol, nsaids, and opiates, all of which have different mechanisms of action and potential dangerous effects (hepatic failure, renal failure, respiratory depression).

minor point - Tylenol would never be approved today if it were a new drug.

 

[Walilamdzi]

Teenage girl accidentally overdosed on paracetamol in bid to cure stomach ache

Georgia Littlewood, 17, was rushed to Huddersfield Infirmary when she started vomiting and mumbling incoherently, but died the next day

www.mirror.co.uk

What do you mean it wouldn't be approved?

 

[SleeplessSoul]

Teenage girl accidentally overdosed on paracetamol in bid to cure stomach ache

Georgia Littlewood, 17, was rushed to Huddersfield Infirmary when she started vomiting and mumbling incoherently, but died the next day

www.mirror.co.uk

She would have had to have taken a lot to end up like this (or just been very unfortunate)

 

[Walilamdzi]

She would have had to have taken a lot to end up like this (or just been very unfortunate)

I do have quite a few? I have 37g.

 

[nerve]

I guess maybe if you OD over and over across a period of time, the damage to your liver will just get to be too much?

 

[Aap]

Max daily dosage has been reduced from 4g per day to 3g due to potential hepatotoxicity. A therapeutic index this low in an otc would NEVER be approved today.

In the event anything I've posted had been misconstrued, trying to ctb with paracetamol is a very bad idea and will likely only to serve to significantly worse one's condition. No one wants to suffer for weeks or months with progressing liver failure