i plan on using acetaminophen for this reason. ibuprofen has always been rough on my stomach, and my stomach's already gonna be pretty unhappy once the SN hits it.
not sure about ibuprofen and inflammation though. but i don't think inflammation is a concern with SN. the main concerns that can be mitigated with meds are nausea, gastric emptying speed, stomach acid presence, tachycardia, speed of unconsciousness, and pain (might be some others too). so unless i'm missing something (which is always possible), i think acetaminophen is probably a safer bet unless you have a specific reaction to the drug that makes ibuprofen a better option.