You can leave a specific request at the front desk to not be disturbed your first day.
You will not need housekeeping to make your bed, or give you clean towels.
You should put the "Do not disturb sign" on the handle.
Many rooms in USA have latches which prevent anyone from outside to open, even with a key, so use that also.
I have done this, not to ctb, but I did go undisturbed the first day.