Has anyone here ever tested mixing benzos with Tagamet?

[Dragon]

Diazepam is not the only benzo that interacts with Tagamet. The reason diazepam stands out from the rest is because the interaction is serious. However, other benzos can still have a mild or significant interaction. The Tagamet can increase the levels of benzos in your blood which can put you at a higher risk of side effects. I'm not sure what these side effects may be, nor am I sure to what extent the levels in your blood increase. Which brings me to the question...has anyone ever tested mixing benzos with Tagamet? I just ordered clonazolam which I plan to use with sn.

 

[jake3d]

The Tagamet can increase the levels of benzos in your blood which can put you at a higher risk of side effects. I'm not sure what these side effects may be, nor am I sure to what extent the levels in your blood increase.

Increased level of benzos in blood = more sleepy more better. For what we want to do, it is actually a good thing.

 

[Ruffian]

https://www.drugs.com/interactions-check.php?drug_list=862-0,669-327 Where are you getting your info? I use this website a lot, and it shows only a minor interaction. If you're basing it off the information from the Amitriptyline cocktail, the Tagamet acts as catalyst to Amitryptyline's time to death, speeding it from 36 hours to 12. Not sure where you're basing info from though.

 

[Dragon]

Increased level of benzos in blood = more sleepy more better. For what we want to do, it is actually a good thing.

Ideally...that is right. But if for some ungodly reason an attempt to ctb were to fail then it would be pretty fucked up to survive with health issues from the benzos...

https://www.drugs.com/interactions-check.php?drug_list=862-0,669-327 Where are you getting your info? I use this website a lot, and it shows only a minor interaction. If you're basing it off the information from the Amitriptyline cocktail, the Tagamet acts as catalyst to Amitryptyline's time to death, speeding it from 36 hours to 12. Not sure where you're basing info from though.

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[jake3d]

Ideally...that is right. But if some ungodly reason an attempt to ctb were to fail then it would be pretty fucked up to survive with health issues from the benzos...

There are no health issues occurring from the short-term use of benzos, at worst you're going to have a hangover. It's long-term use (longer than 3-4 weeks) that is problematic.

 

[Dragon]

There are no health issues occurring from the short-term use of benzos, at worst you're going to have a hangover. It's long-term use (longer than 3-4 weeks) that is problematic.

Except this is not just short term use of benzos. It's a high dose of benzos mixed with another drug that causes an interaction resulting in a higher risk of side effects.

 

[jake3d]

You're overthinking it.

With SN, benzos are competely optional and you don't need to take a high dose if you do choose to take some - people who have taken benzos before SN have been after their anxiolytic effect rather than knocking themselves out. The hypoxia caused by SN ingestion will render you unconscious by itself.

I found this:

Long term treatment with cimetidine and diazepam resulted in a 30 to 80% increase in steady-state diazepam concentrations. In contrast, the pharmacokinetics of oxazepam and lorazepam, which are eliminated almost entirely by glucuronidation and not oxidation, were not altered by cimetidine. Cimetidine also inhibits the metabolism of phenytoin, theophylline and carbamazepine.

Clonazolam is a RC benzo so its exact metabolism is currently unkown.

 

[Ruffian]

Hmmmm, thanks. Never even heard about this before. I never know what I'm going to learn here.

 

[Dragon]

You're overthinking it.

With SN, benzos are competely optional and you don't need to take a high dose if you do choose to take some - people who have taken benzos before SN have been after their anxiolytic effect rather than knocking themselves out. The hypoxia caused by SN ingestion will render you unconscious by itself.

I found this:

Clonazolam is a RC benzo so its exact metabolism is currently unkown.

I know they are optional for ctb but they are absolutely necessary if you want it to be as peaceful as possible. Also, you can't count on the sn rendering you unconscious quickly. Yes, it will knock you unconscious eventually. Ideally, in the best case scenario, it will render you unconscious in 15-20 min. However, there have been reports of people (who supposedly did it correctly) staying conscious for a whole hour before finally freaking out and calling emergency services. I would think this is probably because they unknowingly did something wrong...but it is best to be prepared. With benzos there is no longer a concern. A high dose is necessary to ensure this. Also, benzos help to prevent seizures so it lessons the concern as far as that goes. Last but not least, they lower your inhibitions and help to keep you relaxed through the entire process from start to finish... Clonazolam is extremely powerful too so only about .5 should be needed before and another .5 with the actual sn. Even that might make you black out. But you will go out like a light regardless. Plus, there should be euphoria from both the clonazolam in addition to the sn. Should help to eliminate all fear. Next best thing aside from N... Definitely something I feel everyone should take into consideration.

Holy shit, though. 30-80% increase in concentration?? Big range for some reason. And 80 is really high. That's almost doubling whatever dose you took. That's exactly why it's concerning. Granted that is specifically diazepam and not clonazolam but if there was an 80% increase for .5mg you would be completely floored. And of course that is ideal for this situation, but I still feel it's important to know of any potential side effects that could occur as a result of the interaction.

 

[onlyinsleep]

I know they are optional for ctb but they are absolutely necessary if you want it to be as peaceful as possible. Also, you can't count on the sn rendering you unconscious quickly. Yes, it will knock you unconscious eventually. Ideally, in the best case scenario, it will render you unconscious in 15-20 min. However, there have been reports of people (who supposedly did it correctly) staying conscious for a whole hour before finally freaking out and calling emergency services. I would think this is probably because they unknowingly did something wrong...but it is best to be prepared. With benzos there is no longer a concern. A high dose is necessary to ensure this. Also, benzos help to prevent seizures so it lessons the concern as far as that goes. Last but not least, they lower your inhibitions and help to keep you relaxed through the entire process from start to finish... Clonazolam is extremely powerful too so only about .5 should be needed before and another .5 with the actual sn. Even that might make you black out. But you will go out like a light regardless. Plus, there should be euphoria from both the clonazolam in addition to the sn. Should help to eliminate all fear. Next best thing aside from N... Definitely something I feel everyone should take into consideration.

Holy shit, though. 30-80% increase in concentration?? Big range for some reason. And 80 is really high. That's almost doubling whatever dose you took. That's exactly why it's concerning. Granted that is specifically diazepam and not clonazolam but if there was an 80% increase for .5mg you would be completely floored. And of course that is ideal for this situation, but I still feel it's important to know of any potential side effects that could occur as a result of the interaction.

When is a good time to take a Benzos like lorazepam during this process then?

 

[jake3d]

If you're talking about lorazepam specifically, peak onset would be after 1 hour, but since you will probably want to take a larger dose, i'd take them no sooner than 30 minutes before SN, you may fall asleep before you complete your plan otherwise.

 

[JeSuisMalade]

I have. My first attempt was a combo of approx 700 mg valium, however much alcohol from a day of drinking, grapefruit juice and bromelain - no tagamet. Took it at around 6:30 or 7 PM. Got a call from work on my phone around 1 PM the next day. They sent an ambulance to my apartment shortly after because I didn't show up to work. They used a defibrillator on me in my apartment and then took me to the hospital to treat me for pneumonia from aspirating. I was unconscious the entire time. Doctors woke me up 3 days later.

Second attempt. All of the above plus tagamet. I may have not drank as much but I think I had slightly more valium. I woke up the next day groggy as if nothing happened. No aspirating. I suspect that I didn't drink as much because I may have been overly confident based on my previous attempt because this time I knew nobody would be calling 9-1-1. I don't enjoy the taste of alcohol so I have to push to drink it fast unless I really like what I'm drinking. The tagamet didn't make the valium + vodka + grapefruit juice combo any more lethal.

I read that tagamet increases gastric emptying when it comes to alcohol consumption, too. I don't know what effect that could've had on my attempt. Maybe something about that interaction made it a dud or at least prevented death by aspiration and pneumonia.

My next bus ticket will be SN, meto, and tagamet. Let's hope that third time is a charm and I catch this damn bus finally.

 

[eve2004]

Clonazolam is an RC as someone mentioned and the dose may not be the same as clonazepam (commonly prescribed benzo).

In my opinion you would be better to try to get clonazepam from a walk in clinic or your doctor for an « acute crisis » to reduce anxiety and help insomnia. If you buy any RCs, the purity/quality is unknown and there's no real way to know if it's 100% or not.

Or... (in my dreams) you could get some RCs, get a reagent test kit, and hope the results come back that it's cut with F...

I happen to be on clonazepam and recently bought ranitidine (150mg) so I may give it a try and report back. But I've read on other forums that it did not potentiate the benzo at all.

 

[Lifeisatrap]

I was wondering the same thing. Was looking through the [Method] Members attempting with SN success failure thread. And one of the former members listed under successful @Purple777 had orginally planned on taking 20 bars of xanax but changed their mind and decided on just taking 2 bars before then the rest after the sn. Would injesting sedatives after drinking sn as oppose to before be better? In order not to risk the possibilty of passing out or disorientation before having the chance of even preparing the solution. Or does that carry the possiblity of slowing down absorbtion rate making you more likely to puke?