The first thing I noticed was a huge belly! lol
Well, now being serious, I realized that girls didn't come easy anymore and stopped talking to me.
Also, I noticed how FAKE humanity is, especially in social networks. I mean, just look at instagram! It's all about smiling faces and hot bodies but rather than sex, they want hearts! (likes) and followers.
One more thing to mention, although never happened to me because I'm a freelance teacher (well, I've become a NEET now), is that in job interviews, the cute girl or handsome guy has 100% more chances to get the job than the "ugly" one in spite of their expertise on whatever field they're applying for.