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mordumfan

mordumfan

lizzie //
Aug 12, 2025
25
Can someone who uses them tell me if they do anything, I am very jealous of people who have them prescribed. There is a girl I know who isn't suicidal (not even before she was prescribed them) or depressed. I'm not shaming her at all, I'm just mad because I can't get them when I feel like I desperately need them. Can someone tell me about their personal experiences with anti depressants and if I should keep trying to get them?
 
NutOrat

NutOrat

Falling Down
Jun 11, 2025
255
They haven't worked for me so far, 1 and a half month almost nothing will help me. But they work for other people I think I'm just beyond help no pill will make me want to move.
 
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OnMyLast Legs

OnMyLast Legs

Too many regrets
Oct 29, 2024
610
I think long term your life has to change but they can stop the worst of the worst. When you're bedrotting and your body feels tight and sore and you just can't do anything drugs can help break that.
 
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LastNite

LastNite

Hello World
Mar 31, 2025
500
Heres a list of antidepressants that Ive tried: Prozac, Mirtazapine, Wellbutrin, Zofolt, Lexapro, Cymbalta, Trazodone, and uh I think thats It? I could be wrong maybe missed one or two. But overall experience terrible.

Some side effects Ive experienced with some of these include extreme appetite & no change to depression (Mirtazapine), Constant headaches & Feeling drowsy & no change to depression (Trazodone), brain zaps and pain from withdrawals & no change to depression (Cymbalta). Im pretty sure I missed a few because Ive been trying different ones for well over a year.

Prozac made me feel numb emotionally. I didnt like it. Zofolt which Im currently on uhh Im not exactly sure. I guess I feel ok? I dont think the dose is good though it's 25mg Im planning on trying to increase it after my appointment.

Im impatient btw so my experience is rushed meaning if it didnt work I dont try to increase the dose. For every single drug I mentioned my doc asked me if Im willing to increase the dose to see if it helps and I said no Id like to try something different.
If all else fails Im just gonna do ketamine therapy. It treats people with treatment resistant depression which Im starting to think I got. I wish you the best I hope my input helped. Also please research yourself on what antidepressants you might hate to try. Im not saying dont try it im just saying if your sensitive to pain then be careful with cymbalta & some other hard-to-quit antidepressants because if it doesnt work then quitting alone hurts. The brain zaps are like headache but with electricity and double the pain. When I tried to quit it my doc didnt help me taper off (lean off it) slowly. So I basically quit cold turkey.
 
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mordumfan

mordumfan

lizzie //
Aug 12, 2025
25
They haven't worked for me so far, 1 and a half month almost nothing will help me. But they work for other people I think I'm just beyond help no pill will make me want to move.
Thanks for the response, I'm starting to doubt it would work for me
Heres a list of antidepressants that Ive tried: Prozac, Mirtazapine, Wellbutrin, Zofolt, Lexapro, Cymbalta, Trazodone, and uh I think thats It? I could be wrong maybe missed one or two. But overall experience terrible.

Some side effects Ive experienced with some of these include extreme appetite & no change to depression (Mirtazapine), Constant headaches & Feeling drowsy & no change to depression (Trazodone), brain zaps and pain from withdrawals & no change to depression (Cymbalta). Im pretty sure I missed a few because Ive been trying different ones for well over a year.

Prozac made me feel numb emotionally. I didnt like it. Zofolt which Im currently on uhh Im not exactly sure. I guess I feel ok? I dont think the dose is good though it's 25mg Im planning on trying to increase it after my appointment.

Im impatient btw so my experience is rushed meaning if it didnt work I dont try to increase the dose. For every single drug I mentioned my doc asked me if Im willing to increase the dose to see if it helps and I said no Id like to try something different.
If all else fails Im just gonna do ketamine therapy. It treats people with treatment resistant depression which Im starting to think I got. I wish you the best I hope my input helped. Also please research yourself on what antidepressants you might hate to try. Im not saying dont try it im just saying if your sensitive to pain then be careful with cymbalta & some other hard-to-quit antidepressants because if it doesnt work then quitting alone hurts. The brain zaps are like headache but with electricity and double the pain. When I tried to quit it my doc didnt help me taper off (lean off it) slowly. So I basically quit cold turkey.
that sounds like it sucks ASS. Thanks for the response tho, looks like ill just ctb or find something else
 
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Reactions: NutOrat
NutOrat

NutOrat

Falling Down
Jun 11, 2025
255
I'm sorry no-one should ever listen to me. Don't take what I said seriously.
 
VoidButterfly

VoidButterfly

Flitterby
May 17, 2025
137
They do work, but they aren't miracles and they certainly won't all work for you, it'll be a process to find what works unless you get lucky. I cycled through so many of them.
  • I found SSRIs the least effective, I went through several and experienced everything from nothing to throwing up blood. Sertraline was the best of them for me, it felt like it took the edge off the depression. It certainly didn't fix it, but it made it slightly more tolerable.
  • Then I was on mirtazapine, that's a NASSA (Noradrenaline and specific serotonergic antidepressant) and it was good for anxiety and I stayed on that one for a while.
  • They put me on an SNRI (Serotonin-noradrenaline reuptake inhibitors) called venlafaxine which made me manic as fuck (I'm bipolar). I dunno how that'd work for normal people but it definitely improved my mood lol. I was literally dancing in the street, but unfortunately I also went to work and deleted my code and rewrote it using a hypothesis about prime numbers I developed whilst being unable to sleep.
Anyways, I'm currently on vortioxetine which is a SMS (serotonin modulator and stimulator) and I'd say it helps. When they also added an antipyschotic I genuinely did feel more stable for a long while, it took away the lows but unfortunately also the highs. But then the world made my life infinitely more shit and now I barely even bother taking them. If your life has any hope whatsoever of getting better, I'd say antidepressants are a tool that'll help you get there rather than the fix themselves, if you can find one that works for you.
 
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mordumfan

mordumfan

lizzie //
Aug 12, 2025
25
They do work, but they aren't miracles and they certainly won't all work for you, it'll be a process to find what works unless you get lucky. I cycled through so many of them.
  • I found SSRIs the least effective, I went through several and experienced everything from nothing to throwing up blood. Sertraline was the best of them for me, it felt like it took the edge off the depression. It certainly didn't fix it, but it made it slightly more tolerable.
  • Then I was on mirtazapine, that's a NASSA (Noradrenaline and specific serotonergic antidepressant) and it was good for anxiety and I stayed on that one for a while.
  • They put me on an SNRI (Serotonin-noradrenaline reuptake inhibitors) called venlafaxine which made me manic as fuck (I'm bipolar). I dunno how that'd work for normal people but it definitely improved my mood lol. I was literally dancing in the street, but unfortunately I also went to work and deleted my code and rewrote it using a hypothesis about prime numbers I developed whilst being unable to sleep.
Anyways, I'm currently on vortioxetine which is a SMS (serotonin modulator and stimulator) and I'd say it helps. When they also added an antipyschotic I genuinely did feel more stable for a long while, it took away the lows but unfortunately also the highs. But then the world made my life infinitely more shit and now I barely even bother taking them. If your life has any hope whatsoever of getting better, I'd say antidepressants are a tool that'll help you get there rather than the fix themselves, if you can find one that works for you.
Thank you for this information! Can I also ask if you had any other permanent side effects from taking these? Because my parents were always super against them because they have 'dangerous side effects', and I wanna hear from someone who has actually taken them if its true.
 
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Reactions: VoidButterfly
OnMyLast Legs

OnMyLast Legs

Too many regrets
Oct 29, 2024
610
I think long term your life has to change but they can stop the worst of the worst. When you're bedrotting and your body feels tight and sore and you just can't do anything drugs can help break that.
Wellbutrin seems to be the one working sort of well (I'm on a stack of Rx drugs right now)
 
C

carfemtanyl

Member
Nov 18, 2025
38
I've been on Sertraline/Zoloft for 4 years now and for me, it reduced my dreadful look into the future. Before I took it, I had immense anxiety and dread whenever I thought about the future but now it kinda numbs that away. I also don't feel that much in general while I'm on it but whenever I try to get off it, I'm immediately hit with a bunch of strong negative emotions like the world is ending.
 
F

Forveleth

I knew I forgot to do something when I was 15...
Mar 26, 2024
3,095
There are two things to know about antidepressants. The first is that every single one acts differently for different people. For example, Lexapro might be great for one person and terrible for another. Some people have to go through a dozen antidepressants before they find one that works. So they can work, it just takes some effort to find the right drug.

The second thing is that antidepressants do not actually solve your problems. A lot of people think taking the pill will magically make your life better. That is not how they work. What they do is kick you out of the mental funk you are in so that you are more receptive to things like therapy and life changes that can help you improve your situation. So in that way, antidepressants alone do not solve your problems, but are rather part of an overall tool set.
 
VoidButterfly

VoidButterfly

Flitterby
May 17, 2025
137
Thank you for this information! Can I also ask if you had any other permanent side effects from taking these? Because my parents were always super against them because they have 'dangerous side effects', and I wanna hear from someone who has actually taken them if its true.

I haven't had any permanent side effects that I'm aware of, but there really can be side effects. Some people experience long term sexual dysfunction, there's links to diabetes and heart disease too for people over 30. For some people they can make you more suicidal whch obviously can have its own consequences so you have to be careful about watching for that. And there's just a whole host of random side effects you can experience that usually won't be long term that vary according to the individual meds. I know something a lot of people worry about is that it'll change who you are somehow, I haven't experienced that at all. So yes, lots of side effects, but then depression itself comes with a lot of them too so it's a balancing act.
 
interna

interna

o7 o7 o7 o7
Dec 1, 2025
26
zoloft has somewhat worked for me. but i stopped taking them
 

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