I've wanted to try ayahuasca for a long time, it's just rather difficult for me to either go somewhere it's made or get the ingredients to make it myself.
Shrooms have had the biggest impact for me, certainly the longest lasting positive effects. MDMA (pure, not in pills) also did a great job the first time, but after a couple of weeks it kind of wore off and trying it again years later, I was unable to achieve the same state.
I tried this shit like 5 times and the first 4 times did nothing but a slight buzz. On the 5th time, reality became a book and I felt the pages turning. Was a hell of an experience. Couldn't stop laughing. Also tilting to the side? It was weird. Good weird.