None of the SSRI's I've taken have helped. Some of them (sertraline especially) made my depression worse and others just did nothing. Brintellix did nothing for me.
All that being said, psych meds are incredibly individual in regards to if they work or not for people. You often have to try several meds before finding one that helps. I'm currently only on an antipsychotic and no other types of meds, although I have an upcoming appointment to be medicated for ADHD.