I don't have personal experience but I found this on the internet :
Propranolol is the most common beta-blocker involved in severe beta-blocker poisoning.
Propranolol hydrochloride is a beta-adrenergic blocking drug used in a variety of clinical conditions. Overdoses can result in severe hypotensive states usually associated with bradycardia or asystole or with profound myocardial depression.
We report on an 18-year-old man who ingested a massive dose of propranolol HCl in a suicide attempt.
The patient was brought to the hospital in an unresponsive state within 30 minutes of ingestion. He was initially stabilized but subsequently died nine hours after the drug was ingested.
Amundson DE, et al. Drug Intell Clin Pharm. 1988.
I also found this case.
48-year-old female had consumed more than 5000 mg of propranolol.
Despite high-dose insulin, intravenous sodium bicarbonate, glucagon and inotropic support, she became hypotensive and subsequently arrested.
Extracorporeal life support was weaned off within 67 h, and she survived without neurological deficits. This records the largest propranolol overdose in recent years.
I hope this was somewhat helpful. Good luck for the future.
